Dr. Gautam Chaudhary Profile

Dr. Gautam Chaudhary

Visualization Scientist

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Publications (3)

Proceedings Article | 26 March 2007 Paper

Investigation and visualization of scleral channels created with femtosecond laser in enucleated human eyes using 3D optical coherence tomography images

Gautam Chaudhary, Bin Rao, Dongyul Chai, Zhongping Chen, Tibor Juhasz

Proceedings Volume 6426, 64260B (2007) https://doi.org/10.1117/12.701297

KEYWORDS: Optical coherence tomography, Femtosecond phenomena, 3D image processing, Digital filtering, Image filtering, Visualization, Tissues, Eye, Speckle, Edge detection

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We used optical coherence tomography (OCT) for non-invasive imaging of the anterior segment of the eye for investigating partial-thickness scleral channels created with a femtosecond laser. Glaucoma is associated with elevated intraocular pressure (IOP) due to reduced outflow facility in the eye. A partial-thickness aqueous humor (AH) drainage channel in the sclera was created with 1.7-&mgr;m wavelength femtosecond laser pulses to reduce IOP by increasing the outflow facility, as a solution to retard the progression of glaucoma. It is hypothesized that the precise dimensions and predetermined location of the channel would provide a controlled increase of the outflow rate resulting in IOP reduction. Therefore, it is significant to create the channel at the exact location with predefined dimensions. The aim of this research has two aspects. First, as the drainage channel is subsurface, it is a challenging task to determine its precise location, shape and dimensions, and it becomes very important to investigate the channel attributes after the laser treatment without disturbing the internal anterior structures. Second, to provide a non-invasive, image-based verification that extremely accurate and non-scarring AH drainage channel can be created with femtosecond laser. Partial-thickness scleral channels created in five human cadaver eyes were investigated non-invasively with a 1310-nm time-domain OCT imaging system. Three-dimensional (3D) OCT image stacks of the triangular cornea-sclera junction, also known as anterior chamber angle, were acquired for image-based analysis and visualization. The volumetric cutting-plane approach allowed reconstruction of images at any cross-sectional position in the entire 3D volume of tissue, making it a valuable tool for exploring and evaluating the location, shape and dimension of the channel from all directions. As a two-dimensional image-based methodology, an image-processing pipeline was implemented to enhance the channel features to augment the analysis. In conclusion, we successfully demonstrate that our image-based visualization tool is appropriate for effective investigation and evaluation of femtosecond laser-created, partial-thickness aqueous humor drainage channels in the sclera.

Proceedings Article | 22 February 2007 Paper

Imaging subsurface photodisruption in human sclera with FD-OCT

Bin Rao, Jianping Su, Dongyul Chai, Gautam Chaudhary, Zhongping Chen, Tibor Juhasz

Proceedings Volume 6429, 642910 (2007) https://doi.org/10.1117/12.704857

KEYWORDS: 3D image processing, Sclera, Optical coherence tomography, Femtosecond phenomena, Imaging systems, Laser ablation, Laser tissue interaction, Laser systems engineering, 3D vision, Natural surfaces

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Proceedings Article | 6 February 2007 Paper

Aqueous humor outflow effects of partial thickness channel created by a femtosecond laser in ex-vivo human eyes

Dongyul Chai, Gautam Chaudhary, Ron Kurtz, Tibor Juhasz

Proceedings Volume 6435, 64350O (2007) https://doi.org/10.1117/12.701416

KEYWORDS: Eye, Laser therapeutics, Femtosecond phenomena, Sclera, Microscopes, Control systems, Raster graphics, Resistance, Pulsed laser operation, Laser systems engineering

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