Mr. George Russell Glenn Profile

George Russell Glenn

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Proceedings Article | 24 February 2010 Paper

PIRATE: pediatric imaging response assessment and targeting environment

Russell Glenn, Yong Zhang, Matthew Krasin, Chiaho Hua

Proceedings Volume 7625, 76251S (2010) https://doi.org/10.1117/12.858618

KEYWORDS: Tumors, Positron emission tomography, Analytical research, Image analysis, Image segmentation, Magnetic resonance imaging, Cancer, Medical imaging, Oncology, Clinical trials

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By combining the strengths of various imaging modalities, the multimodality imaging approach has potential to improve tumor staging, delineation of tumor boundaries, chemo-radiotherapy regime design, and treatment response assessment in cancer management. To address the urgent needs for efficient tools to analyze large-scale clinical trial data, we have developed an integrated multimodality, functional and anatomical imaging analysis software package for target definition and therapy response assessment in pediatric radiotherapy (RT) patients. Our software provides quantitative tools for automated image segmentation, region-of-interest (ROI) histogram analysis, spatial volume-of-interest (VOI) analysis, and voxel-wise correlation across modalities. To demonstrate the clinical applicability of this software, histogram analyses were performed on baseline and follow-up ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET images of nine patients with rhabdomyosarcoma enrolled in an institutional clinical trial at St. Jude Children's Research Hospital. In addition, we combined ¹⁸F-FDG PET, dynamic-contrast-enhanced (DCE) MR, and anatomical MR data to visualize the heterogeneity in tumor pathophysiology with the ultimate goal of adaptive targeting of regions with high tumor burden. Our software is able to simultaneously analyze multimodality images across multiple time points, which could greatly speed up the analysis of large-scale clinical trial data and validation of potential imaging biomarkers.

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