Dr. Glenn McGall Profile

Dr. Glenn McGall

at Centrillion Biosciences Inc

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Proceedings Article | 22 March 2000 Paper

High-density oligonucleotide probe arrays

Glenn McGall, Jacqueline Fidenza

Proceedings Volume 3926, (2000) https://doi.org/10.1117/12.380501

KEYWORDS: Glasses, Photolysis, Polymers, Polymer thin films, Manufacturing, Chemistry, Analog electronics, Analytical research, Biological research, Medical research

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High-density DNA probe arrays offer a massively parallel approach to nucleic acid sequence analysis that will have a major impact on gene-based biomedical research and clinical diagnostics. Light-directed synthesis has enabled the large- scale manufacture of arrays containing hundreds of thousands of oligonucleotide probe sequences on a glass `chip' about 1.6 cm² in size. This method is used to produce high- density GeneChip^TM probe arrays, which are now finding widespread use in the detection and analysis of mutations and polymorphisms (`genotyping'), and in a wide range of gene expression studies. This paper will discuss methods for high-resolution photolithographic array fabrication which integrate solid-phase oligonucleotide synthesis, photochemically removable protecting groups, and lithographic techniques adapted from the microelectronics industry.

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