For the past two decades intensive research has been carried out on the development of environmental sensors. Nevertheless, the applicability of such devices has been hindered by harsh work conditions and the complexity of the sample matrices. A novel approach centres on the integration of sample pre-treatment steps, where the technology involved can be used advantageously for the design of a Micro Total Analysis System (fluid motion and detection enhancement). The synergistic mixed surfactant system allows the development an independent "green" target specific extraction scheme. Amphiphiles are routinely used in the electrophoretic separation process for their intrinsic detection signal enhancement (i.e. by optical/electrochemical methods). They can also be regarded as a means of flow generation (e.g. Marangoni's Flow) in micro-systems. In this perspective, we are currently developing micro-systems based on glass and polymeric substrates (e.g. poly dimethyl silicone). Whilst the surface chemistry of glass substrates allows the integration of mesoporous silica and ceramics, soft lithographic methods, such as micro-moulding or prototyping, renders the design of PDMS substrate simple. While the selectivity of the system may be based on molecular imprinted silicates, biologically compatible ceramics such as titanium dioxide can be used for the design of a single optical/ electrochemical detection cell. All of these previously cited technologies form a standing bridge towards independent, automated, at-/on-line sensor systems.