Dr. Henry Hirschberg Profile

Dr. Henry Hirschberg

at Univ of Nevada Las Vegas

SPIE Involvement:

Conference Chair | Conference Program Committee | Author | Editor

Publications (58)

SPIE Journal Paper | February 7, 2018

Limiting glioma development by photodynamic therapy-generated macrophage vaccine and allo-stimulation: an in vivo histological study in rats

Madsen, Steen J. , Christie, Catherine , Huynh, Khoi , Peng, Qian , Uzal, Francisco A. , Krasieva, Tatiana B. , Hirschberg, Henry

JBO Vol. 23 Issue 02

KEYWORDS: Tumors, Photodynamic therapy, Brain, In vivo imaging, Cell death, Cancer, Flow cytometry, OSLO, Animal model studies, Phase contrast

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PROCEEDINGS ARTICLE | April 19, 2017

Macrophages as drug delivery vehicles for photochemical internalization (Conference Presentation)

Proc. SPIE. 10050, Clinical and Translational Neurophotonics

KEYWORDS: Medical laser equipment, Cancer, Tumors, Tissues, Blood, Nanoparticles, Toxicity, Therapeutic agents, Lanthanum, In vitro testing

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SPIE Journal Paper | July 21, 2016

Focused ultrasound-mediated sonochemical internalization: an alternative to light-based therapies

Gonzales, Jonathan , Nair, Rohit , Madsen, Steen J. , Krasieva, Tatiana , Hirschberg, Henry

JBO Vol. 21 Issue 07

KEYWORDS: Therapeutics, Tumors, Toxicity, Ultrasonography, Photodynamic therapy, Tissues, Macromolecules, In vitro testing, Luminescence, Oxygen

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PROCEEDINGS ARTICLE | April 26, 2016

Activation of photodynamic therapy in vitro with Cerenkov luminescence generated from Yttrium-90 (Conference Presentation)

Proc. SPIE. 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV

KEYWORDS: Breast, Photodynamic therapy, Tumor growth modeling, Tumors, Tissues, Luminescence, In vivo imaging, In vitro testing, Current controlled current source

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PROCEEDINGS ARTICLE | March 9, 2016

Increasing the efficacy of antitumor glioma vaccines by photodynamic therapy and local injection of allogeneic glioma cells

Proc. SPIE. 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation

KEYWORDS: Medical laser equipment, Photodynamic therapy, Cancer, Tumors, Tissues, Radium, OSLO, Standards development, Brain

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SPIE Journal Paper | January 25, 2016

Photothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages: in vitro squamous cell carcinoma study

Madsen, Steen , Shih, En-Chung , Peng, Qian , Christie, Catherine , Krasieva, Tatiana , Hirschberg, Henry

JBO Vol. 21 Issue 01

KEYWORDS: Near infrared, Tumors, In vitro testing, Nanoparticles, Gold, Toxicity, In vivo imaging, Particles, Absorbance, Cancer

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SPIE Conference Volume | April 3, 2015

Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II

PROCEEDINGS ARTICLE | March 10, 2015

Macrophage mediated PCI enhanced gene-directed enzyme prodrug therapy

Proc. SPIE. 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II

KEYWORDS: Nose, Detection and tracking algorithms, Tumors, Imaging systems, Sensors, Matrices, Linear filtering, Digital imaging, Convolution, Channel projecting optics

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PROCEEDINGS ARTICLE | March 10, 2015

Efficacy of combined photothermal therapy and chemotherapeutic drugs

Proc. SPIE. 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II

KEYWORDS: Neck, Near infrared, Cancer, Breast cancer, Tumors, Nanoparticles, Toxicity, Head, In vitro testing, Absorption

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PROCEEDINGS ARTICLE | February 26, 2015

Combined concurrent nanoshell loaded macrophage-mediated photothermal and photodynamic therapies

Proc. SPIE. 9303, Photonic Therapeutics and Diagnostics XI

KEYWORDS: Gold, Neck, Near infrared, Medical laser equipment, Photodynamic therapy, Cancer, Tumors, Nanoparticles, Head, Absorbance

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SPIE Journal Paper | October 23, 2014

Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier

Zamora, Genesis , Wang, Frederick , Sun, Chung-Ho , Trinidad, Anthony , Kwon, Young Jik , Cho, Soo Kyung , Berg, Kristian , Madsen, Steen , Hirschberg, Henry

JBO Vol. 19 Issue 10

KEYWORDS: Tumors, Control systems, Nanoparticles, Photodynamic therapy, Neptunium, Toxicity, Brain, Cancer, In vitro testing, Magnesium

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SPIE Conference Volume | March 24, 2014

Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics

PROCEEDINGS ARTICLE | March 20, 2014

Ultra-low fluence rate photodynamic therapy: simulation of light emitted by the Cerenkov effect

Proc. SPIE. 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics

KEYWORDS: Visible radiation, Phototherapy, Photodynamic therapy, Tumors, Diagnostics and therapeutics, Tissue optics, Radioisotopes, Cerenkov radiation imaging, Light, Absorption

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PROCEEDINGS ARTICLE | March 5, 2014

Photochemical internalization (PCI) enhanced nonviral transfection of tumor suppressor and pro-drug activating genes; a potential treatment modality for gliomas

Proc. SPIE. 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics

KEYWORDS: Photodynamic therapy, Green fluorescent protein, Cancer, Tumors, Nanoparticles, Macromolecules, Picosecond phenomena, OSLO, In vitro testing, Brain

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PROCEEDINGS ARTICLE | March 5, 2014

Photothermal therapy of human glioma spheroids with gold-silica nanoshells and gold nanorods: a comparative study

Proc. SPIE. 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics

KEYWORDS: Gold, Near infrared, Tissues, Nanoparticles, Particles, Electrons, Light scattering, Absorbance, Absorption, Nanorods

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SPIE Conference Volume | March 15, 2013

Photonic Therapeutics and Diagnostics IX

PROCEEDINGS ARTICLE | March 8, 2013

Effects of combined photochemical internalization and hyperthermia are sensitively dependent on radiant exposure

Proc. SPIE. 8565, Photonic Therapeutics and Diagnostics IX

KEYWORDS: Oncology, Photodynamic therapy, Cancer, Tumors, Macromolecules, Oxygen, Toxicity, Therapeutics, In vitro testing, Temperature metrology

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SPIE Journal Paper | May 3, 2012

Photochemical internalization of bleomycin for glioma treatment

Mathews, Marlon , Shih, En-Chung , Zamora, Genesis , Sun, Chung-Ho , Hirschberg, Henry , Blickenstaff, Joseph , Vo, Van , Madsen, Steen

JBO Vol. 17 Issue 5

KEYWORDS: Tumors, Photodynamic therapy, Brain, Control systems, Toxicity, Blood brain barrier, In vitro testing, Cell death, Two photon excitation microscopy, Plasma

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PROCEEDINGS ARTICLE | February 9, 2012

Enhanced gene transfection by photochemical internalization of protomine sulfate/DNA complexes

Proc. SPIE. 8207, Photonic Therapeutics and Diagnostics VIII

KEYWORDS: Proteins, Laser therapeutics, Photodynamic therapy, Green fluorescent protein, Cancer, Tumors, Macromolecules, Picosecond phenomena, Stem cells, Brain

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SPIE Conference Volume | February 3, 2012

Photonic Therapeutics and Diagnostics VIII

PROCEEDINGS ARTICLE | February 18, 2011

Photothermal ablation of malignant brain tumors by nanoparticle loaded macrophages

Proc. SPIE. 7883, Photonic Therapeutics and Diagnostics VII

KEYWORDS: Gold, Near infrared, Cancer, Tumors, Silica, Nanoparticles, Control systems, In vitro testing, Blood brain barrier, Brain

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PROCEEDINGS ARTICLE | February 18, 2011

Enhanced transfection of brain tumor suppressor genes by photochemical internalization

Proc. SPIE. 7883, Photonic Therapeutics and Diagnostics VII

KEYWORDS: Confocal microscopy, Proteins, Laser therapeutics, Photodynamic therapy, Green fluorescent protein, Tumors, Microscopy, Macromolecules, Control systems, Brain

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SPIE Conference Volume | February 3, 2011

Photonic Therapeutics and Diagnostics VII

PROCEEDINGS ARTICLE | March 3, 2010

Near-infrared-activated gold nanoshells for thermal ablation of macrophages in vitro

Proc. SPIE. 7548, Photonic Therapeutics and Diagnostics VI

KEYWORDS: Gold, Near infrared, Iron, Tumors, Visualization, Nanoparticles, Magnetic resonance imaging, Particles, Laser ablation, In vitro testing

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PROCEEDINGS ARTICLE | March 3, 2010

Bypassing the blood-brain barrier: delivery of therapeutic agents by macrophages

Proc. SPIE. 7548, Photonic Therapeutics and Diagnostics VI

KEYWORDS: Photodynamic therapy, Tumors, Blood, Nanoparticles, Collagen, Therapeutic agents, Therapeutics, Lanthanum, Blood brain barrier, Brain

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SPIE Conference Volume | February 8, 2010

Photonic Therapeutics and Diagnostics VI

PROCEEDINGS ARTICLE | July 13, 2009

Targeted opening of the blood brain barrier by ALA-mediated photodynamic therapy

Proc. SPIE. 7380, Photodynamic Therapy: Back to the Future

KEYWORDS: Photodynamic therapy, Cancer, Tumors, Tissues, Magnetic resonance imaging, Capillaries, Pathology, Diffusion, Blood brain barrier, Brain

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PROCEEDINGS ARTICLE | February 23, 2009

Photochemical internalization enhances the efficacy of bleomycin in malignant glioma cells

Proc. SPIE. 7161, Photonic Therapeutics and Diagnostics V

KEYWORDS: Proteins, Photodynamic therapy, Cancer, Tumors, Macromolecules, Toxicity, Chlorine, In vitro testing, Blood brain barrier, Brain

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PROCEEDINGS ARTICLE | February 23, 2009

Selective disruption of the blood-brain barrier by photochemical internalization

Proc. SPIE. 7161, Photonic Therapeutics and Diagnostics V

KEYWORDS: Photodynamic therapy, Cancer, Tumors, Magnetic resonance imaging, Molecules, Macromolecules, Chlorine, Lanthanum, Blood brain barrier, Brain

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SPIE Conference Volume | February 16, 2009

Photonic Therapeutics and Diagnostics V

SPIE Conference Volume | March 4, 2008

Photonic Therapeutics and Diagnostics IV

PROCEEDINGS ARTICLE | February 26, 2008

The effect of motexafin gadolinium on ALA photodynamic therapy in glioma spheroids

Proc. SPIE. 6842, Photonic Therapeutics and Diagnostics IV

KEYWORDS: Magnesium, Photodynamic therapy, Cancer, Tumors, Tissues, In vivo imaging, Tissue optics, Gadolinium, In vitro testing, Brain

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PROCEEDINGS ARTICLE | February 8, 2008

Evaluation of a novel gadolinium-based contrast agent for intraoperative magnetic resonance imaging

Proc. SPIE. 6842, Photonic Therapeutics and Diagnostics IV

KEYWORDS: Photodynamic therapy, Tumors, Tissues, Surgery, Magnetic resonance imaging, Image enhancement, Neuroimaging, Gadolinium, Blood brain barrier, Brain

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PROCEEDINGS ARTICLE | February 8, 2008

Disruption of the blood brain barrier following ALA mediated photodynamic therapy

Proc. SPIE. 6842, Photonic Therapeutics and Diagnostics IV

KEYWORDS: Medicine, Photodynamic therapy, Tumors, Tissues, Magnetic resonance imaging, Pathology, Neuroimaging, Tissue optics, Blood brain barrier, Brain

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PROCEEDINGS ARTICLE | March 23, 2007

Increased brain edema following 5-aminolevulinic acid mediated photodynamic in normal and tumor bearing rats

Proc. SPIE. 6424, Photonic Therapeutics and Diagnostics III

KEYWORDS: Photodynamic therapy, Tumors, Tissues, Magnetic resonance imaging, Skin, Luminescence, Distance measurement, Neuroimaging, Blood brain barrier, Brain

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Introduction: Failure of treatment for high grade gliomas is usually due to local recurrence at the site of surgical resection indicating that a more aggressive form of local therapy, such as PDT, could be of benefit. PDT causes damage to both tumor cells as well as cerebral blood vessels leading to degradation of the blood brain barrier with subsequent increase of brain edema. The increase in brain edema following ALA-PDT was evaluated in terms of animal survival, histopatological changes in normal brain and tumor tissue and MRI scanning. The effect of steroid treatment, to reduce post-treatment PDT induced edema, was also examined. Methods:Tumors were established in the brains of inbred BD-IX and Fisher rats. At various times following tumor induction the animals were injected with ALA ip. and four hours later light treatment at escalating fluences and fluence rates were given. Nontumor bearing control animals were also exposed to ALA-PDT in a similar manner to evaluate damage to normal brain and degree of blood brain barrier (BBB) disruption. Results: Despite a very low level of PpIX production in normal brain, with a 200:1 tumor to normal tissue selectivity ratio measured at a distance of 2 mm from the tumor border, many animals succumbed shortly after treatment. A total radiant energy of 54 J to non-tumor bearing animals resulted in 50% mortality within 5 days of treatment. Treatment of tumor bearing animals with moderate fluence levels produced similar brain edema compared to higher fluence levels. ALA PDT in nontumor bearing animals produced edema that was light dose dependent. PDT appeared to open the BBB for a period of 24-48 hrs after which it was restored. The addition of post operative steroid treatment reduced the incident of post treatment morbidity and mortality. Conclusions: T2 and contrast enhanced T1 MRI scanning proved to be a highly effective and non-evasive modality in following the development of the edema reaction and the degree and time course of BBB dysfunction thus allowing the use of fewer animals.

PROCEEDINGS ARTICLE | March 23, 2007

Comparing the effects of repetitive and chronic ALA mediated PDT on human glioma spheroids

Proc. SPIE. 6424, Photonic Therapeutics and Diagnostics III

KEYWORDS: Medical laser equipment, Photodynamic therapy, Tumors, Tissues, Luminescence, Oxygen, Molybdenum, In vitro testing, Brain, Fetus

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PROCEEDINGS ARTICLE | March 23, 2007

Photochemical internalization for the treatment of malignant gliomas

Proc. SPIE. 6424, Photonic Therapeutics and Diagnostics III

KEYWORDS: Medicine, Laser therapeutics, Photodynamic therapy, Cancer, Luminescence, Macromolecules, Oxygen, Toxicity, Lanthanum, In vitro testing

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SPIE Conference Volume | March 6, 2007

Photonic Therapeutics and Diagnostics III

SPIE Journal Paper | January 1, 2007

Determination of fluence rate and temperature distributions in the rat brain; implications for photodynamic therapy

Angell-Petersen, Even , Hirschberg, Henry , Madsen, Steen

JBO Vol. 12 Issue 01

KEYWORDS: Brain, Tumors, Temperature metrology, Diffusion, Monte Carlo methods, Scattering, Absorption, Photodynamic therapy, Light scattering, Optical properties

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PROCEEDINGS ARTICLE | February 22, 2006

ALA-PDT of glioma cell micro-clusters in BD-IX rat brain

Proc. SPIE. 6078, Photonic Therapeutics and Diagnostics II

KEYWORDS: Photodynamic therapy, Cancer, Tumors, Tissues, Luminescence, Control systems, Toxicity, Lanthanum, Blood brain barrier, Brain

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PROCEEDINGS ARTICLE | February 22, 2006

Reduction of the invasiveness of human glioma cells by ALA-mediated photodynamic therapy

Proc. SPIE. 6078, Photonic Therapeutics and Diagnostics II

KEYWORDS: Proteins, Photodynamic therapy, Cancer, Tumors, Ionizing radiation, Collagen, Lanthanum, Molybdenum, In vitro testing, Brain

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PROCEEDINGS ARTICLE | February 22, 2006

Investigating the effects of combined photodynamic and anti-angiogenic therapies using a three-dimensional in vivo brain tumor system

Proc. SPIE. 6078, Photonic Therapeutics and Diagnostics II

KEYWORDS: Photodynamic therapy, Tumors, Tissues, Blood vessels, Interfaces, 3D modeling, Therapeutics, In vivo imaging, Content addressable memory, Brain

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SPIE Conference Volume | February 15, 2006

Photonic Therapeutics and Diagnostics II

PROCEEDINGS ARTICLE | April 25, 2005

Addition of ionizing radiation or hyperthermia enhances PDT efficacy in glioma spheroids

Proc. SPIE. 5686, Photonic Therapeutics and Diagnostics

KEYWORDS: Proteins, Photodynamic therapy, Atrial fibrillation, Tumors, Tissues, Luminescence, Ionizing radiation, Control systems, Cell death, Gamma radiation

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SPIE Conference Volume | April 25, 2005

Photonic Therapeutics and Diagnostics

PROCEEDINGS ARTICLE | April 25, 2005

ALA-mediated photodynamic therapy of experimental malignant glioma in the BD-IX rat model

Proc. SPIE. 5686, Photonic Therapeutics and Diagnostics

KEYWORDS: Photodynamic therapy, Tumor growth modeling, Cancer, Tumors, Tissues, Luminescence, Cell death, In vitro testing, Brain, Animal model studies

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PROCEEDINGS ARTICLE | April 25, 2005

Development of a brain tumor model for investigating the effects of photodynamic and anti-angiogenic therapies

Proc. SPIE. 5686, Photonic Therapeutics and Diagnostics

KEYWORDS: Quantum wells, Photodynamic therapy, Tumors, Blood vessels, Diagnostics, Therapeutics, Content addressable memory, Brain

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PROCEEDINGS ARTICLE | July 13, 2004

Interstitial light application for photodynamic therapy in a rat brain tumor model

Proc. SPIE. 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV

KEYWORDS: Photodynamic therapy, Tumors, Scattering, Diffusion, Light scattering, Monte Carlo methods, Tissue optics, Absorption, Brain, Animal model studies

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PROCEEDINGS ARTICLE | July 13, 2004

Repetitive 5-aminolevulinic acid mediated photodynamic therapy of rat glioma

Proc. SPIE. 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV

KEYWORDS: Photodynamic therapy, Tumors, Tissues, Luminescence, In vivo imaging, Tissue optics, OSLO, In vitro testing, Brain, Animal model studies

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PROCEEDINGS ARTICLE | July 13, 2004

Protoporphyrin IX distribution in rat brain following administration of 5-aminolevulinic acid or its hexylester

Proc. SPIE. 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV

KEYWORDS: Cancer, Data modeling, Tumors, Tissues, Luminescence, Biopsy, OSLO, Blood brain barrier, Brain, Animal model studies

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SPIE Conference Volume | July 13, 2004

Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV

PROCEEDINGS ARTICLE | June 13, 2003

Development of an in-vivo model for the study of photodynamic therapy and anti-angiogenic treatments

Proc. SPIE. 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII

KEYWORDS: Medical laser equipment, Photodynamic therapy, Cancer, Tumors, Collagen, Therapeutics, In vivo imaging, Lanthanum, Content addressable memory, Animal model studies

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PROCEEDINGS ARTICLE | June 6, 2002

Effects of low-fluence-rate PDT on glioma spheroids

Proc. SPIE. 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI

KEYWORDS: Carbon, Carbon dioxide, Medical laser equipment, Photodynamic therapy, Cancer, Tumors, Tissues, Lanthanum, OSLO, Brain

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PROCEEDINGS ARTICLE | June 6, 2002

Photodynamic therapy of human glioma spheroids: a comparative study of the effectiveness of 5-aminolevulinic acid and its esters

Proc. SPIE. 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI

KEYWORDS: Medical laser equipment, Photodynamic therapy, Cancer, Tumors, Tissues, Diffusion, Lanthanum, Molybdenum, OSLO, In vitro testing

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PROCEEDINGS ARTICLE | July 9, 2001

Characterization of optical and thermal distributions from an intracranial balloon applicator for photodynamic therapy

Proc. SPIE. 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Thermography, Photodynamic therapy, Tissues, Scattering, Sensors, Optical testing, Tissue optics, Spherical lenses, Natural surfaces, Brain

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PROCEEDINGS ARTICLE | April 9, 2001

Fluence rate effects in human glioma spheroids: implications for photodynamic therapy of brain tumors

Proc. SPIE. 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X

KEYWORDS: Medical laser equipment, Photodynamic therapy, Cancer, Tumors, Skin, Oxygen, Tissue optics, Lanthanum, OSLO, Brain

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PROCEEDINGS ARTICLE | July 6, 1999

Effects of photodynamic therapy on human glioma spheroids

Proc. SPIE. 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII

KEYWORDS: Medical laser equipment, Photodynamic therapy, Tumors, Tissues, Luminescence, Ionizing radiation, Tissue optics, Lanthanum, Plasma, Brain

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PROCEEDINGS ARTICLE | June 14, 1999

Optical dosimetry in photodynamic therapy of human uterus and brain

Proc. SPIE. 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Photodynamic therapy, Modulation, Optical properties, Tissues, Sensors, Diffusion, Optical testing, Tissue optics, Uterus, Brain

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Showing 5 of 58 publications

Conference Committee Involvement (14)