PROCEEDINGS ARTICLE | September 3, 2008
Proc. SPIE. 7074, Advanced Signal Processing Algorithms, Architectures, and Implementations XVIII
KEYWORDS: Statistical analysis, Surgery, Electrodes, Magnetic resonance imaging, Signal processing, Distance measurement, Electroencephalography, Neodymium, Epilepsy, Brain
Two studies of brain networks, performed on interictal intracranial EEGs recorded during the presurgical evaluation of
patients with epilepsy, are presented in this report. In the first we examine pairwise relationships between pre-defined
brain regions in 12 patients, 6 with medial temporal onset of seizures and 6 with frontal and parietal onset of seizures.
We demonstrate that differences, in pairwise relationships between brain regions, allow a distinction of these two groups
of patients. In the second study we evaluate short, mid, and long-distance brain connectivity as a function of distance to
the seizure onset area in another 2 patients. We demonstrate that the measures of brain connectivity distinguish between
brain areas which are close to and far from the seizure onset area. The results of the two studies may help both define
large scale brain networks involved in the generation of seizures, and localize the area of seizure onset.
