Prof. Holger F. Boehm Profile

Prof. Holger F. Boehm

Associate Professor of Radiology at Klinikum der Univ München

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Publications (21)

Proceedings Article | 11 March 2011 Paper

Texture analysis of clinical radiographs using radon transform on a local scale for differentiation between post-menopausal women with and without hip fracture

Holger Boehm, Markus Körner, Bernhard Baumert, Ulrich Linsenmaier, Maximilian Reiser

Proceedings Volume 7962, 79620L (2011) https://doi.org/10.1117/12.876517

KEYWORDS: Bone, Dual energy x-ray absorptiometry, Radiography, Neck, Radon transform, Head, Minerals, X-rays, Diagnostics, X-ray imaging

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Proceedings Article | 27 March 2009 Paper

Preliminary study report: topological texture features extracted from standard radiographs of the heel bone are correlated with femoral bone mineral density

H. Boehm, J. Lutz, M. Koerner, M. Notohamiprodjo, M. Reiser

Proceedings Volume 7259, 725954 (2009) https://doi.org/10.1117/12.810738

KEYWORDS: Bone, Radiography, Minerals, X-ray imaging, Diagnostics, X-rays, Dual energy x-ray absorptiometry, Medical imaging, Image processing, Feature extraction

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Proceedings Article | 28 February 2009 Paper

Quantitative local topological texture properties obtained from radiographs of the proximal femur in patients with pertrochanteric and transcervical hip fractures

H. Boehm, J. Lutz, M. Koerner, M. Notohamiprodjo, M. Reiser

Proceedings Volume 7260, 726006 (2009) https://doi.org/10.1117/12.810636

KEYWORDS: Radiography, Bone, Statistical analysis, Head, Neck, Medical imaging, Image classification, Error analysis, 3D image processing, Image processing

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The incidence of osteoporosis and associated fractures becomes an increasingly relevant issue for the public health institutions of industrialized nations. Fractures of the hip represent the worst complication of osteoporosis with a significantly elevated rate of mortality. Prediction of fracture risk is a major focus of osteoporosis research and, over the years, has been approched from different angles. There exist two distinct subtypes of transcervical and pertrochanteric hip fracture that can be distinguished on the basis of the anatomical location of the injury. While the epidemiology of hip fractures has been well described, typically, little or no distinction is made between the subtypes. The object of this study was to determine whether local topological texture properties based on the Minkowski Functionals (MF) obtained from standard radiographs of the proximal femur in patients with hip fracture can be used to differentiate between the two types of fracture pattern. The texture features were extracted from standardized regions of interest (femoral head, neck, and pertrochanteric region) in clinical radiographs of the hip obtained from 90 post-menopausal women (69.8 ± 7.9 yrs). 30 of the women had sustained pertrochanteric fractures, 30 had transcervical hip fractures and 30 were age-matched controls. We determined an optimized topological parameter MF2Dloc using an integrative filtering procedure based on a sliding-windows algorithm. Statistical relationship between the fracture type (pertrochanteric/transcervical) and the value of MF2Dloc was assessed by receiver-operator characteristic (ROC) analysis. Depending on the anatomical location of the region of interest for texture analysis correct classification of tanscervial and pertrochanteric fractures ranged from AUC = 0.79 to 0.98. In conclusion, quantitative texture properties of trabecular bone extracted from radiographs of the hip can be used to identify patients with hip fracture and to distinguish between pertrochanteric and transcervical fracture types. The degree of correct classification varies with choice of anatomical site for texture analysis. The results of our study may help to understand the mechanism of the two types of hip fracture.

Proceedings Article | 17 March 2008 Paper

Application of the Minkowski-functionals for automated pattern classification of breast parenchyma depicted by digital mammography

Holger Boehm, Tanja Fischer, Dororthea Riosk, Stefanie Britsch, Maximilian Reiser

Proceedings Volume 6915, 691522 (2008) https://doi.org/10.1117/12.754867

KEYWORDS: Breast, Mammography, Tissues, Image classification, Cancer, Breast cancer, Digital mammography, Radiology, Computer aided diagnosis and therapy, Breast imaging

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Proceedings Article | 11 March 2008 Paper

A novel approach to fracture-risk-assessment in osteoporosis by ROI-oriented application of the Minkowski-functionals to dual x-ray absorptiometry scans of the hip

Holger Boehm, Alexandra Panteleon, Tobias Vogel, Dominik Burklein, Maximilian Reiser

Proceedings Volume 6914, 69144M (2008) https://doi.org/10.1117/12.755286

KEYWORDS: Bone, Dual energy x-ray absorptiometry, Minerals, Neck, Standards development, X-rays, Image analysis, Medical imaging, Image processing, Statistical analysis

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Proceedings Article | 29 March 2007 Paper

Automated characterization of normal and pathologic lung tissue by topological texture analysis of multidetector CT

H. Boehm, C. Fink, C. Becker, M. Reiser

Proceedings Volume 6514, 65140N (2007) https://doi.org/10.1117/12.702697

KEYWORDS: Tissues, Lung, Emphysema, 3D image processing, X-ray computed tomography, Image processing, Biopsy, Visualization, Medical imaging, Chest imaging

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Proceedings Article | 3 March 2007 Paper

Orientation-weighted local Minkowski functionals in 3D for quantitative assessment of trabecular bone structure in the hip

H. Boehm, H. Bitterling, C. Weber, V. Kuhn, F. Eckstein, M. Reiser

Proceedings Volume 6512, 65124D (2007) https://doi.org/10.1117/12.702447

KEYWORDS: Bone, Neck, 3D image processing, Tissues, Computed tomography, Magnetic resonance imaging, Minerals, Densitometry, 3D metrology, Gait analysis

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Proceedings Article | 20 March 2006 Paper

Analysis of the topological properties of the proximal femur on a regional scale: evaluation of multi-detector CT-scans for the assessment of biomechanical strength using local Minkowski functionals in 3D

H. Boehm, T. Link, R. Monetti, V. Kuhn, F. Eckstein, C. Raeth, M. Reiser

Proceedings Volume 6144, 61446X (2006) https://doi.org/10.1117/12.650469

KEYWORDS: Bone, Neck, Head, 3D image processing, Biological research, Image processing, Dual energy x-ray absorptiometry, Radiology, Magnetic resonance imaging, Computed tomography

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Proceedings Article | 10 March 2006 Paper

Optimizing texture measures quantifying bone structures as well as MR-sequences at 3 Tesla: an integrative statistical approach

Christoph Raeth, Dirk Mueller, Ernst Rummeny, Thomas Link, Mika Vogel, Hartmut Koenig, Holger Boehm, Roberto Monetti

Proceedings Volume 6144, 61440E (2006) https://doi.org/10.1117/12.652131

KEYWORDS: Bone, Spatial resolution, Signal to noise ratio, Distance measurement, Image resolution, Visualization, Magnetic resonance imaging, 3D image processing, Image analysis, Statistical analysis

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Proceedings Article | 10 March 2006 Paper

Quantifying changes in the bone microarchitecture using Minkowski-functionals and scaling vectors: a comparative study

Christoph Raeth, Dirk Mueller, Thomas Link, Holger Boehm, Roberto Monetti

Proceedings Volume 6144, 61440C (2006) https://doi.org/10.1117/12.653129

KEYWORDS: Bone, Distance measurement, Control systems, Anisotropy, Solids, Radiology, Image processing, Minerals, Calcium, Tissues

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Proceedings Article | 29 April 2005 Paper

Performance of linear and nonlinear texture measures in 2D and 3D for monitoring architectural changes in osteoporosis using computer-generated models of trabecular bone

Holger Boehm, Thomas Link, Roberto Monetti, Dirk Mueller, Ernst Rummeny, Christoph Raeth

Proceedings Volume 5747, (2005) https://doi.org/10.1117/12.592649

KEYWORDS: Bone, 3D modeling, Data modeling, Performance modeling, Computer simulations, Therapeutics, Tissues, Spherical lenses, Biological research, In vivo imaging

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Osteoporosis is a metabolic bone disease leading to de-mineralization and increased risk of fracture. The two major factors that determine the biomechanical competence of bone are the degree of mineralization and the micro-architectural integrity. Today, modern imaging modalities (high resolution MRI, micro-CT) are capable of depicting structural details of trabecular bone tissue. From the image data, structural properties obtained by quantitative measures are analysed with respect to the presence of osteoporotic fractures of the spine (in-vivo) or correlated with biomechanical strength as derived from destructive testing (in-vitro). Fairly well established are linear structural measures in 2D that are originally adopted from standard histo-morphometry. Recently, non-linear techniques in 2D and 3D based on the scaling index method (SIM), the standard Hough transform (SHT), and the Minkowski Functionals (MF) have been introduced, which show excellent performance in predicting bone strength and fracture risk. However, little is known about the performance of the various parameters with respect to monitoring structural changes due to progression of osteoporosis or as a result of medical treatment. In this contribution, we generate models of trabecular bone with pre-defined structural properties which are exposed to simulated osteoclastic activity. We apply linear and non-linear texture measures to the models and analyse their performance with respect to detecting architectural changes. This study demonstrates, that the texture measures are capable of monitoring structural changes of complex model data. The diagnostic potential varies for the different parameters and is found to depend on the topological composition of the model and initial “bone density”. In our models, non-linear texture measures tend to react more sensitively to small structural changes than linear measures. Best performance is observed for the 3rd and 4th Minkowski Functionals and for the scaling index method.

Proceedings Article | 29 April 2005 Paper

Structural analysis of human proximal femur for the prediction of biomechanical strength in vitro: the locally adapted scaling vector method

Roberto Monetti, Holger Boehm, Dirk Mueller, Ernst Rummeny, Thomas Link, Christoph Raeth

Proceedings Volume 5747, (2005) https://doi.org/10.1117/12.594470

KEYWORDS: Bone, Samarium, In vitro testing, Image analysis, Dual energy x-ray absorptiometry, Tissues, Distance measurement, 3D metrology, Minerals, Magnetic resonance imaging

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Proceedings Article | 29 April 2005 Paper

Improving the textural characterization of trabecular bone structure to quantify its changes: the locally adapted scaling vector method

Christoph Raeth, Dirk Mueller, Holger Boehm, Ernst Rummeny, Thomas Link, Roberto Monetti

Proceedings Volume 5747, (2005) https://doi.org/10.1117/12.594059

KEYWORDS: Bone, Distance measurement, Anisotropy, Minerals, Control systems, Image processing, Radiology, Partial differential equations, Nonlinear filtering, Differential equations

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Proceedings Article | 29 April 2005 Paper

Morphological filtering based on the Minkowski functionals in 3D for segmentation of macromolecular structures in intact eukaryotic cells depicted by cryo-electron tomography

Holger Boehm, Ferdinand Jamitzki, Roberto Monetti, Dirk Mueller, Alexandros Linaroudis, Reiner Hegerl, Ernst Rummeny, Christoph Raeth

Proceedings Volume 5747, (2005) https://doi.org/10.1117/12.593717

KEYWORDS: Image segmentation, Tomography, 3D image processing, Image filtering, 3D image reconstruction, Image transmission, Image processing, Image processing algorithms and systems, Transmission electron microscopy, Medical imaging

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Proceedings Article | 12 May 2004 Paper

The 3D-based scaling index algorithm to optimize structure analysis of trabecular bone in postmenopausal women with and without osteoporotic spine fractures

Dirk Muller, Roberto Monetti, Holger Bohm, Jan Bauer, Ernst Rummeny, Thomas Link, Christoph Rath

Proceedings Volume 5370, (2004) https://doi.org/10.1117/12.533244

KEYWORDS: Bone, Spine, Magnetic resonance imaging, Image segmentation, Image resolution, Diagnostics, Algorithm development, 3D image processing, Receivers, Minerals

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Proceedings Article | 12 May 2004 Paper

Application of the Minkowski functionals in 3D to high-resolution MR images of trabecular bone: prediction of the biomechanical strength by nonlinear topological measures

Holger Boehm, Thomas Link, Roberto Monetti, Dirk Mueller, Ernst Rummeny, David Newitt, Sharmila Majumdar, Christoph Raeth

Proceedings Volume 5370, (2004) https://doi.org/10.1117/12.532835

KEYWORDS: Bone, Magnetic resonance imaging, 3D image processing, Minerals, Image resolution, Tissues, Spatial resolution, Medical imaging, Standards development, Image processing

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Proceedings Article | 12 May 2004 Paper

Assessing the biomechanical strength of trabecular bone in vitro using 3D anisotropic nonlinear texture measures: the scaling vector method

Roberto Monetti, Holger Bohm, Dirk Muller, Ernst Rummeny, Thomas Link, Christoph Rath

Proceedings Volume 5370, (2004) https://doi.org/10.1117/12.532708

KEYWORDS: Bone, Samarium, In vitro testing, Distance measurement, Tissues, Dual energy x-ray absorptiometry, Magnetic resonance imaging, In vivo imaging, Neck, Metals

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Proceedings Article | 12 May 2004 Paper

Comparing nonlinear texture measures for quantifying trabecular bone structures using surrogates

Christoph Rath, Roberto Monetti, Dirk Muller, Holger Bohm, Ernst Rummeny, Thomas Link

Proceedings Volume 5370, (2004) https://doi.org/10.1117/12.533471

KEYWORDS: Bone, Magnetic resonance imaging, Algorithms, Distance measurement, Image resolution, Statistical analysis, Quality measurement, Minerals, 3D image processing, Nonlinear filtering

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Proceedings Article | 15 May 2003 Paper

Application of the standard Hough transform to high-resolution MRI of human trabecular bone to predict mechanical strength

Holger Bohm, Christoph Rath, Roberto Monetti, Dirk Muller, David Newitt, Sharmila Majumdar, Ernst Rummeny, Thomas Link

Proceedings Volume 5032, (2003) https://doi.org/10.1117/12.481137

KEYWORDS: Bone, Magnetic resonance imaging, In vitro testing, Minerals, Hough transforms, Computed tomography, Tissues, Spine, Fractal analysis, Spatial resolution

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Proceedings Article | 15 May 2003 Paper

Scaling index method: a novel nonlinear technique for the analysis of high-resolution MRI of human bones

Roberto Monetti, Holger Bohm, Dirk Muller, David Newitt, Sharmila Majumdar, Ernst Rummeny, Thomas Link, Christoph Rath

Proceedings Volume 5032, (2003) https://doi.org/10.1117/12.481099

KEYWORDS: Bone, Samarium, Magnetic resonance imaging, Spine, Distance measurement, Image filtering, 3D image processing, In vitro testing, Magnetism, Image resolution

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Proceedings Article | 15 May 2003 Paper

Analyzing and selecting texture measures for quantifying trabecular bone structures using surrogates

Christoph Rath, Roberto Monetti, Dirk Muller, Holger Bohm, Ernst Rummeny, Thomas Link

Proceedings Volume 5032, (2003) https://doi.org/10.1117/12.480448

KEYWORDS: Bone, 3D image processing, Magnetic resonance imaging, Nonlinear dynamics, Distance measurement, Statistical analysis, Medical imaging, Fourier transforms, Nonlinear filtering, Quality measurement

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Showing 5 of 21 publications

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