Objective: Ho:YAG laser had been used to treat the common diseases of urinary system such as bladder cancer and benign prostatic hyperplasia in our hospital. This study is to assess the efficacy and safety of transurethral Ho:YAG-laser resection to treat the urethral stricture and bladder neck contracture. Methods: From May 1997 to August 2004, 26 cases of urethral stricture and 33 cases of bladder neck contracture were treated by transurethral Ho:YAG-laser resection. These patients were followed up at regular intervals after operation. The uroflow rate of these patients was detected before and one-month after operation. The blood loss and the energy consumption of holmium-laser during the operation as well as the complications and curative effect after operation were observed. Results: The therapeutic effects were considered successful, with less bleeding and no severe complications. The Qmax of one month postoperation increased obviously than that of preoperation. Of the 59 cases, restenosis appeared in 11 cases (19%) with the symptoms of dysuria and weak urinary stream in 3-24 months respectively. Conclusions: The Ho:YAG-laser demonstrated good effect to treat the obstructive diseases of lower urinary tract such as urethral stricture and bladder neck contracture. It was safe, minimal invasive and easy to operate.
Objective: To observe the Effect of Oral Mucoid Cyst Treated by Ho:YAG Laser. Methods: The patients suffering from oral mucoid cyst were treated by Ho:YAG laser, which energy per pulse is 0.5j, pulse per second 5~15Hz, average power 2.5~7.5w. Result: Among all the patients were cured for one time. Conclusion: The technique of treatment of oral mucoid cyst with Ho:YAG laser is an effect and safe thearapeutics with the characteristics of excellent homeostasis, improved visualization, minimal thermal damage to surrounding tissue, shorter period of recovery and easy to operate. The total effect of Ho:YAG laser is better than CO<sub>2</sub> laser and Nd:YAG laser.
Objective: To observe and explore the effects and mechanism of apoptosis on canine induced by Laser. Try to find a new approach to treat of armpit odor with no traumatism. Method: We used different power of semiconductor Laser to irradiate the black hair canine to observe and evaluate the tissue effects with electroscope, flow cytometry and Tunel technique at different period of time after irradiation. Result: The apoptosis has been observed within the hair follicle cells and apocrine gland cells after irradiation. After repeat irradiation in low power level, more apoptosis has been observed. Conclusion: Apoptosis exists in hair follicle cells and apocrine gland cells after Laser irradiation.
Objective: Research on the photodynamic therapy of malignancy of skin with He-Ne Laser. Methods: 35 cases of skin malignancy were treated with photodynamic therapy. He-Ne laser with output power of 600 mW was used and hematoporphyrin derivative (HPD) was applied, at a dose of 5mg/kg of body. 15 patients received simple surface irradiation, 20 patients received both surface and insertion irradiation. 28 patients underwent treatment for one time, 7 patients twice. The 12 cases were basel cell carcinoma, 7 cases were squamous cell carcinoma, 4 cases were skin carcinoma in situ, 8 cases were skin Paget's disease, 1 case was Paget's disease accompanying adenoid carcinoma, 1 case malignant melanoma, 1 case red hypertrophic disease, 1 case recurrent perianal carcinoma deriving from rectum.
Objective: To observe the effectiveness of treatment of xanthelasma palpebrarum with ultrapulsed co<sub>2</sub> laser. Methods: 36 patients of Xanthelasma Palpebrarum (78 periorbital xanthelasmas) were treated with ultrapulsed CO<sub>2</sub> laser irradiating on lesions. Results: All lesions could be removed completely with a single laser treatment. After 1~10 months follow-up time, no visible scarring was observed. 4 patients (11.11%) developed a recurrence of xanthelasma. Conclusion: The ultrapulsed CO<sub>2</sub> laser is an effective and safe therapeutic alternative to all the other surgical procedures.
Objective: The purpose of this study to evaluate the effectiveness of Ho: YAG laser irradiation in treatment of condylomata acuminata. Methods: 1025 patients of condylomata acuminata, in which the lesions of 620 patients were interior of different lacuna, the lesions in 79 patients were huge (the diameter of lesion is over than 5cm), and 26 patients were pregnant, were treated with Ho:YAG laser (0.5-0.8J/pulse, 5-15 pulses/sec) to melt all the lesions. Results: All lesions in 1025 patients were removed after one laser treatment. The recrudescent and regenerative lesions could be removed completely after repeated treatment. No scarring and stricture on the peristome of the urethra was observed. No abortion, premature delivery and other syndrome were occurred among the total 26 pregnant patients. Conclusion: The technique of treatment of condylomata acuminata with Ho:YAG laser is an effective and safe therapeutics with the characteristic of better function of the homeostasis, shorter period of the concrescence and easy to operate.
Objective: To observe the effect of Ho:YAG laser in treatment of urethra cauncle. Methods: The patients suffering from urethra cauncle were treated by Ho:YAG laser, the energy of per pulse is 0.5J. The frequency of pulse is 5~15Hz, and the average power of the laser is 2.5~7.5W. Results: Among the patients 188 cases of urethra cauncle were only cured for one time, twice for 12 cases. No stricture on the peristome of urethra or urethrovaginal fistula was observed. Conclusions: The technique of treatment of urethra cauncle with Ho:YAG laser is an effect and safe therapeutics with the merit of excellent homeostasis, improved visualization, minimal thermal damage to surrounding tissue, shorter period of recovery and easy to operate. It is better than CO<sub>2</sub> laser and Nd:YAG laser.
Objective: The title is research curative effect of intravascular low level laser irradiation (ILLLI) in treatment of psoriasis. Method: 478 patients with psoriasis from five groups to observe their efficacy. Group1 were treated by He-Ne laser combined with drug. Group 2 were treated by semi-conductor laser combined with drug. Group 3 were treated only by He-He laser. Group 4 were treated by semi-conductor laser. Group 5 were treated only by drug. The Ridit statistical analysis was applied to all of these data. The treatment of intravascular low level laser irradiation is as follow: laser power: 4-5mw, 1 hour per day and 10 days as a period combined with vit C 2.0 g iv and inhalation of O2. Results: The clinical results: the near efficient rate was 100%, in group 1-4, if combined with drugs it would be better. Ridit statistical analysis showed no significant difference between group1-4, p>0.05. The efficient rate 72.97% in group5.There were showed very significant difference with group1-4, p<0.01. 2.There were no significant differences between He-Ne laser (632.8nm) and semiconductor laser (650nm); 3.The efficacy of ILLLI in psoriasis was positive correlation to the ILLLI times.
Conclusions: It can improve curative effect of intravascular low levellaser irradiation (ILLLI) in treatment of psoriasis.
Objective: To observe and study the improvement of the technique in treatment of internal hemorrhoids with Nd:YAG laser and evaluate the effective rate. Methods: 60 patients of internal hemorrhoids were treated with Nd:YAG laser (10-15mw) irradiating on the mucosa of the lesions. Results: Among 60 patients, 57 patients were primarily cured with one treatment, 3 patients were primarily cured with two treatments. The effective rate was 95% with one treatment, and it reached to 100% with two treatments. Conclusions: the improvement of the technique in treatment of internal hemorrhoids with Nd:YAG laser is effective and easy to operate.
Liu TCY et al have put forward the biological information model on low intensity laser irradiation (BIML): low intensity laser irradiation couples with intracellular messenger through the chromophore absorption in the cell membrane: hot-color laser irradiation activates cAMP phosphodiestererase through G<SUB>i</SUB> protein, or activates phosphoinositide phospholipase C through G protein, or activates one of receptor-associated kinases: cAMP; cold- color laser irradiation activates adenylate cyclase through G<SUB>s</SUB> protein: cAMP$ARUP. In this paper, under the guidance of BIML, we applied the intravascular low intensity He-He laser irradiation on blood to a patient of idiopathic edema, and succeeded.
Laser induced fluorescence technique is a convienient, non-traumatic and high sensitive mehtod for tumor detection. The principle is that photosensitizers such as hematoporphyrin derivtives (HpD) has a special affinity to cancerous tissues. Being injected hematoporphyrin and excited with laser of a certain wavelength, cancerous tissues have characteristic fluorescentic peaks near 630 nm and 690 nm, while no such peaks have been observed in normal tissues. So it can be applied to tumor diagnosis. In this paper, we report small dosage of hematoporphyrin is applied to photosensitive diagnosis and the establishment of laser-induced fluorescence detection system with optical multichannel analysis (OMA) as it core. The LIF system is composed of three parts: 1 . fluorescence excitation and reception including laser machine as the exciting resource, exciting and recepting part and the corresponding light path coupling system. 2. photo-electricity transformation including OMA 4 system, electricity resource, cooling device, multi-color device with three gratings, and the multi-color device monitor. 3. computer signals handling including computer (Gateway 2000, 486 DX2/66). Control band connecting computer with OMA, printer, spectrum analysis and data transformation software. This paper introduced the system structure, regulaiton and operation methods in detail. Among them, the establishment of an excellent light path system, especially the good coupling between the exciting part (laser machine) and the recepting part (OMA) is the key to success .We have exprimented three kinds of fibers: coaxial fiber, parallel fiber and monofilament fiber. After comparing their advantages, disadvantages and working ways, we choose two pieces of paralled fibers (600nm) used to diagnosis of intralumatic tumors in clinic. Development of manofilament fiber is being carried out, too, The appropriate choice o flaser machine also has a great influuence to the exciting efeciency. Pratice has indicated that this system has high sensitivity and wide dynamic range. It is easy to operate the programme with menu can greatly improve the effeciency. With fiber, it can be applied to detect both superficial and intralumatic tumors. Complicated data handling also can be carried out with the advanced spectrum analysis programme. From our experimental and clinical reults, we believe this system has atained primary requirements on designment and clinic. In order to increase the sensitivity and reduce the sufferings of patients. Improvement of this system is necessary.
Among tumors of urinary system, the morbidity of bladder cancer is the first one. It is multiple, also has high risk of regeneration. The paper reports that 679 bladder tumors in 108 patients had treated for 284 times by pulsed HO:YAG laser from July 1994-June 1997.