In this study, we successfully generated the large bandwidth of supercontinuum spectra through hollow fibers filled with DNA. Also, by observing that spectra bandwidth was the widest in the order of the hollow core fiber filled with DNA modified by copper ion, the hollow core fiber with only DNA, and the bulk hollow core fiber, we demonstrated that DNA material modified with copper ions can further enhance the spectral bandwidth of supercontinuum. As a result, we anticipate that the SCG as a broadband light source can be used in analytical methods to demonstrate a wide range of biological and environmental questions.
The luminescence and magnetic resonance imaging (MRI) and photodynamic therapy (PDT) using lanthanide-doped
upconverting nanoparticles (UCNPs) is reported. With the aim to induce a therapeutic effect, a photosensitizer, chlorin
e6 (Ce6), was conjugated to UCNPs. Owing to the enhanced permeability and retention effect, UCNPs combined with a
photosensitizer, chlorin e6 (UCNP-Ce6) could be readily accumulated at the tumors, which could be clearly observed not
only in the upconversion luminescence image but also in the MRI image. Using the energy transfer from UCNPs to Ce6,
cytotoxic singlet oxygen could be generated. An in vivo PDT effect by systemic administration of UCNP-Ce6 was
demonstrated under 980-nm irradiation. These results indicate that UCNP-Ce6 can be used not only as dual-modal
imaging probes for accurate diagnosis but also as photodynamic therapy agent for efficient therapy.