Multichannel Fiber Optic Probes (MFOP) is new type of accessories’ which can be used for Modern Biophotonics Techniques, based on: UV-VIS- NIR spectroscopy, fluorescent spectroscopy. New simulations program MFOBv.3 for MFOP allow to specify basic reflex light optic value I0 as a function of distance Z[μm] have been developed. MFOBv.3 make possible quick selection and optimization of the probe fiber bundle structure and fibers specification. Designed Reflex probe for endoscopy spectral evaluations include new type of fibers. Fibers with core surrounded by hollow circular guide provide necessary wide numerical aperture. Multimode metal coated fibers used in MFOP for tumor diagnostic in surgery. Symbioses of Microtechnology and new types of fiberoptic allow made smallest Reflex probe 7+1 fibers structure (OD=0.6mm). Designed sensitive electronic system with 405nm/50mW laser synchronized with fluorescent signals measurement device. For tumor diagnostic during stomach surgery created high sensitive endoscopic fiber multichannel probe for special photosensitizer with excitation wavelength 405 nm. Reflex probe provide sensitivity small than 10 microgram photosensitizer for 1 kg biomass. Experimental results for bio liquids and for tissue with laser induced fluorescence diagnostic extended in poster/report.
Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control. Pharmacokinetic studies on laboratory animals and volunteers were carried out. The results have shown that the dipotassium salt of Yb3+-dimethoxyhematoporphyrin IX, which is highly soluble in water and stable in storage, is a promising marker for earlier diagnostics of tumors and can be used in dermatology, dentistry, gynecology, cosmetology, ear, nose, and throat diseases, veterinary, and in other areas of medicine.