Phenothiazine exposed to white light or UV radiation undergoes a variety of reactions that result in the degradation of the parental compound and the formation of new species. Chlorpromazine exposed to the 266 nm laser beam of given energy levels yielded species derived from it, whose number increased with the exposure duration. At distinct time intervals the irradiation products were evaluated by spectrophotometry between 200-1500 nm, Thin Layer Chromatography, and for antimicrobial activity of Chlorpromazine against different test organisms such as Staphylococcus aureus.
One of the alternatives to the existing medicines and treatment procedures in fighting multi drug
resistance (MDR) is strengthening the effects of medicines by modifying their molecular structures through
exposure to laser radiation. A method associated with this, is the generation of micro-droplets which contain
medicines solutions; the droplets are utilized/produced as vectors to transport the medicines to targets.
In our studies we try to combine these two methods in order to obtain a new technique to deliver the
efficient medicines to targets that can be applied for a relative large number of chemicals. For this purpose we
have developed an experimental set-up containing a liquid droplets generator, a tunable laser source used to
irradiate droplets, a subunit to measure the laser induced fluorescence (LIF) signals and a real time recording
system for droplet image analysis.
Measurements on different probes, like ultrapure water, commercial grade medicines, newly
developed medicines and laser dyes were performed.. All these measurements were performed on waterbased
We present in this paper the laser induced fluorescence measurements results on medicine solutions
(in bulk or in a micro-droplet form) that exhibit important modifications after the exposure at laser radiation. It
was evidenced that the exposures to laser beams/coherent optical radiation of some medicines solutions in
ultrapure water may produce molecular modifications in solutions. These slight modifications of the molecules
made them more efficient against bacteria strains.