Dr. James A. Guggenheim Profile

Dr. James A. Guggenheim

Research Fellow at Univ of Birmingham

SPIE Involvement:

Author

Area of Expertise:

Photoacoustic Imaging

Publications (25)

Proceedings Article | 11 August 2023 Paper

Simulating optical memory effects and the scanning of foci using wavefront shaping in tissue-like scattering media

Jake A. J. Bewick, Peter R. T. Munro, Simon Arridge, James Guggenheim

Proceedings Volume 12632, 126321H (2023) https://doi.org/10.1117/12.2670438

KEYWORDS: Scattering media, Tissues, Wavefronts, Light scattering, Speckle pattern, Geometrical optics, Tissue optics, Plane waves, Optical simulations, Incident light

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Proceedings Article | 11 August 2023 Paper

Interrogating Fabry-Perot ultrasound sensors with Bessel beams for photoacoustic imaging

Dylan Marques, Oliver Sheppard, Edward Zhang, Paul Beard, Peter R. T. Munro, James Guggenheim

Proceedings Volume 12631, 126310U (2023) https://doi.org/10.1117/12.2675686

KEYWORDS: Bessel beams, Sensors, Gaussian beams, Acquisition tracking and pointing, Acoustics, Frequency response, Ultrasonography, Photoacoustic tomography, Fabry–Perot interferometers, Mirrors

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Proceedings Article | 11 August 2023 Paper

Ultrasonic field mapping through a multimode optical fibre

Benjamin Keenlyside, Dylan Marques, Nathaniel Redgewell, Maxim Cherkashin, David Phillips, Edward Zhang, Paul Beard, James Guggenheim

Proceedings Volume 12631, 126310S (2023) https://doi.org/10.1117/12.2675616

KEYWORDS: Scattering compensation, Light scattering, Scattered light, Photoacoustic tomography, Adaptive optics, Sensors, Ultrasonography, Wavefronts, Ultrasonics, Optical fibers, Laser ultrasonics, Spatial light modulators, Ultrasound transducers, Endoscopes

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Proceedings Article | 16 March 2023 Presentation

Full-wave simulation of focusing light through scattering layers using the T-matrix method (Conference Presentation)

Jake Bewick, Peter Munro, Simon Arridge, James Guggenheim

Proceedings Volume PC12388, PC1238808 (2023) https://doi.org/10.1117/12.2649918

KEYWORDS: Light scattering, Scattering, Computer simulations, Wavefronts, Titanium dioxide, Scattering media, Phase modulation, Particles

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Proceedings Article | 9 March 2023 Presentation

Development of high sensitivity plano-concave optical microresonators sensors for photoacoustic imaging

David Martin-Sanchez, Edward Zhang, Zhixin Liu, James Guggenheim, Paul Beard

Proceedings Volume PC12379, PC123791O (2023) https://doi.org/10.1117/12.2654566

KEYWORDS: Sensors, Photoacoustic imaging, Microresonators, Image sensors, Ultrasonography, Transducers, Signal detection, Signal attenuation, Protactinium, Photoacoustic spectroscopy

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Proceedings Article | 9 March 2023 Presentation

Increasing the sensitivity of Fabry-Perot ultrasound sensor using Bessel beam interrogation: a feasibility study

Dylan Marques, Oliver Sheppard, Edward Zhang, Paul Beard, Peter R. Munro, James Guggenheim

Proceedings Volume PC12379, PC123790F (2023) https://doi.org/10.1117/12.2652174

KEYWORDS: Sensors, Bessel beams, Photoacoustic tomography, Fabry–Perot interferometers, Imaging systems, Tissue optics, Acquisition tracking and pointing, Prototyping, Image sensors, Image resolution

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Proceedings Article | 9 March 2023 Paper

Photoacoustic wavefront shaping with a long coherence length laser

Maxim Cherkashin, Benjamin Keenlyside, Thomas Allen, Paul Beard, James Guggenheim

Proceedings Volume 12379, 1237913 (2023) https://doi.org/10.1117/12.2652242

KEYWORDS: Photoacoustic imaging, Photoacoustic microscopy, Adaptive optics, Tissues, Scattering media, Spatial light modulators, Light scattering, Wavefronts, Diffusers, Tissue optics, Speckle pattern, Speckle, Photoacoustic spectroscopy

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Proceedings Article | 9 March 2023 Presentation + Paper

A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping

Jake A. J. Bewick, Peter R. Munro, Simon Arridge, James Guggenheim

Proceedings Volume 12379, 123790D (2023) https://doi.org/10.1117/12.2656075

KEYWORDS: Tissues, Light scattering, Spatial resolution, Wavefronts, Photoacoustic spectroscopy, Monte Carlo methods, Computer simulations, Systems modeling, Speckle, Spatial light modulators, Scattering media, Mie scattering, Computational modeling, Photoacoustic imaging, Modeling

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Proceedings Article | 8 March 2021 Presentation

Breaking sensitivity limits of optical ultrasound sensors used in photoacoustic imaging

James Guggenheim, Dylan Marques, Peter R. Munro, David Martin-Sanchez, Edward Zhang, Paul Beard

Proceedings Volume 11642, 1164207 (2021) https://doi.org/10.1117/12.2582730

KEYWORDS: Sensors, Absorption, Ultrasonography, Microresonators, Tissue optics, Photoacoustic spectroscopy, Tissues, Polymers, Optical resolution, Image resolution

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Proceedings Article | 5 March 2021 Presentation

Wavefront shaping through multimode fibres to enable endoscopic photoacoustic tomography

Benjamin Keenlyside, Dylan Marques, Maxim Cherkashin, Edward Zhang, Peter Munro, Paul Beard, James Guggenheim

Proceedings Volume 11652, 116520M (2021) https://doi.org/10.1117/12.2582995

KEYWORDS: Endoscopy, Multimode fibers, Wavefronts, Photoacoustic tomography, Ultrasonography, Sensors, Tomography, Photoacoustic spectroscopy, Photoacoustic imaging, Imaging systems

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Proceedings Article | 5 March 2021 Presentation

Plano-concave microresonator sensors for photoacoustic imaging: optical sensitivity maximization using transfer matrix model

David Martin-Sanchez, James Guggenheim, Edward Zhang, Dylan Marques, Peter R. Munro, Paul Beard

Proceedings Volume 11642, 116421X (2021) https://doi.org/10.1117/12.2580696

KEYWORDS: Photoacoustic imaging, Sensors, Microresonators, Optical arrays, Imaging arrays, Tissues, Tissue optics, Gaussian beams, Ultrasonography, Polymers

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Proceedings Article | 5 March 2021 Presentation

Studying the impact of roughness on the sensitivity of Fabry-Pérot sensors for photoacoustic imaging

Dylan Marques, James Guggenheim, Edward Zhang, Paul Beard, David Martin-Sanchez, Peter R. Munro

Proceedings Volume 11642, 1164222 (2021) https://doi.org/10.1117/12.2582081

KEYWORDS: Sensors, Photoacoustic imaging, Image sensors, Tissue optics, Polymers, Ultrasonography, Polymeric sensors, Photoacoustic spectroscopy, Image resolution

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Proceedings Article | 5 March 2021 Presentation

Jolab a free and open-source software to simulate light propagation in optical systems

Dylan Marques, James Guggenheim, Peter R. Munro

Proceedings Volume 11649, 1164914 (2021) https://doi.org/10.1117/12.2577631

KEYWORDS: Optical components, Optical simulations, Optical design, Optical coherence tomography, Computer simulations, Wavefronts, Systems modeling, Structural design, Physics

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Proceedings Article | 20 April 2020 Presentation

Flatness of planar Fabry-Pérot cavities: a critical parameter for high sensitivity sensors for photoacoustic imaging (Conference Presentation)

Dylan Marques, James Guggenheim, Rehman Ansari, Edward Zhang, Paul Beard, Peter R. Munro

Proceedings Volume 11240, 112400V (2020) https://doi.org/10.1117/12.2548971

KEYWORDS: Sensors, Photoacoustic imaging, Image sensors, Manufacturing, Mirrors, Photoacoustic spectroscopy, Reflectivity

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Proceedings Article | 5 March 2020 Presentation + Paper

Interrogation of Fabry-Pérot ultrasound sensors with Bessel beams

Oliver Sheppard, James Guggenheim, Dylan Marques, Rehman Ansari, Edward Zhang, Paul Beard, Peter R. Munro

Proceedings Volume 11240, 1124014 (2020) https://doi.org/10.1117/12.2551305

KEYWORDS: Bessel beams, Sensors, Reflectivity, Ultrasonography, Fabry–Perot interferometers, Mirrors, Axicons, Gaussian beams, Visibility, Silica

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Proceedings Article | 19 July 2019 Paper

Probing the optical readout characteristics of Fabry-Perot ultrasound sensors through realistic modelling

Dylan Marques, James Guggenheim, Rehman Ansari, Edward Zhang, Paul Beard, Peter R. Munro

Proceedings Volume 11077, 110770H (2019) https://doi.org/10.1117/12.2527114

KEYWORDS: Sensors, Reflectivity, Ultrasonography, Signal detection, Modeling, Mirrors, Interferometers, Photoacoustic imaging, Mathematical modeling

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Proceedings Article | 27 February 2019 Presentation + Paper

On the intuitive understanding of interrogating Fabry-Perot etalon with a focused beam

Dylan Marques, James Guggenheim, Rehman Ansari, Edward Zhang, Paul Beard, Peter R. Munro

Proceedings Volume 10878, 108780Q (2019) https://doi.org/10.1117/12.2508413

KEYWORDS: Fabry–Perot interferometers, Sensors, Mirrors, Wave propagation, Beam propagation method, Photoacoustic imaging, Signal detection

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Proceedings Article | 23 March 2017 Presentation + Paper

Photoacoustic imaging with planoconcave optical microresonator sensors: feasibility studies based on phantom imaging

James Guggenheim, Edward Zhang, Paul Beard

Proceedings Volume 10064, 100641V (2017) https://doi.org/10.1117/12.2249993

KEYWORDS: Sensors, Microresonators, Photoacoustic imaging, Ultrasonography, Imaging systems, Acoustics, Photoacoustic spectroscopy, Image sensors, Fabry–Perot interferometers, Receivers, Image quality, Mirrors, Tissues, Tomography

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Proceedings Article | 27 April 2016 Presentation

Planoconcave optical microresonator sensors for photoacoustic imaging: pushing the limits of sensitivity (Conference Presentation)

James Guggenheim, Edward Zhang, Paul Beard

Proceedings Volume 9708, 97082M (2016) https://doi.org/10.1117/12.2210869

KEYWORDS: Sensors, Microresonators, Fabry–Perot interferometers, Photoacoustic imaging, Image sensors, Photoacoustic spectroscopy, Scanners, Breast imaging, Ultrasonography, Opacity

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Most photoacoustic scanners use piezoelectric detectors but these have two key limitations. Firstly, they are optically opaque, inhibiting backward mode operation. Secondly, it is difficult to achieve adequate detection sensitivity with the small element sizes needed to provide near-omnidirectional response as required for tomographic imaging. Planar Fabry-Perot (FP) ultrasound sensing etalons can overcome both of these limitations and have proved extremely effective for superficial (<1cm) imaging applications. To achieve small element sizes (<100μm), the etalon is illuminated with a focused laser beam. However, this has the disadvantage that beam walk-off due to the divergence of the beam fundamentally limits the etalon finesse and thus sensitivity - in essence, the problem is one of insufficient optical confinement. To overcome this, novel planoconcave micro-resonator sensors have been fabricated using precision ink-jet printed polymer domes with curvatures matching that of the laser wavefront. By providing near-perfect beam confinement, we show that it is possible to approach the maximum theoretical limit for finesse (f) imposed by the etalon mirror reflectivities (e.g. f=400 for R=99.2% in contrast to a typical planar sensor value of f<50). This yields an order of magnitude increase in sensitivity over a planar FP sensor with the same acoustic bandwidth. Furthermore by eliminating beam walk-off, viable sensors can be made with significantly greater thickness than planar FP sensors. This provides an additional sensitivity gain for deep tissue imaging applications such as breast imaging where detection bandwidths in the low MHz can be tolerated. For example, for a 250 μm thick planoconcave sensor with a -3dB bandwidth of 5MHz, the measured NEP was 4 Pa. This NEP is comparable to that provided by mm scale piezoelectric detectors used for breast imaging applications but with more uniform frequency response characteristics and an order-of-magnitude smaller element size. Following previous proof-of-concept work, several important advances towards practical application have been made. A family of sensors with bandwidths ranging from 3MHz to 20MHz have been fabricated and characterised. A novel interrogation scheme based on rapid wavelength sweeping has been implemented in order to avoid previously encountered instability problems due to self-heating. Finally, a prototype microresonator based photoacoustic scanner has been developed and applied to the problem of deep-tissue (>1cm) photoacoustic imaging in vivo. Imaging results for second generation microresonator sensors (with R = 99.5% and thickness up to ~800um) are compared to the best achievable with the planar FP sensors and piezoelectric receivers.

SPIE Journal Paper | 26 May 2015 Open Access

Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast

James Guggenheim, Thomas Allen, Andrew Plumb, Edward Zhang, Manuel Rodriguez-Justo, Shonit Punwani, Paul Beard

JBO, Vol. 20, Issue 05, 050504, (May 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.5.050504

KEYWORDS: Lymphatic system, Photoacoustic imaging, Cancer, Photoacoustic spectroscopy, Absorption, Visualization, Sensors, 3D image processing, Magnetic resonance imaging, Signal to noise ratio

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Proceedings Article | 11 March 2015 Paper

Frequency response and directivity of highly sensitive optical microresonator detectors for photoacoustic imaging

James Guggenheim, Jing Li, Edward Zhang, Paul Beard

Proceedings Volume 9323, 93231C (2015) https://doi.org/10.1117/12.2082514

KEYWORDS: Sensors, Microresonators, Photoacoustic imaging, Imaging systems, Data modeling, Acoustics, Image sensors, Mirrors, Deep tissue imaging, Coating

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Proceedings Article | 14 June 2013 Paper

Information-theoretic method for wavelength selection in bioluminescence tomography

Hector Basevi, James Guggenheim, Hamid Dehghani, Iain Styles

Proceedings Volume 8799, 879909 (2013) https://doi.org/10.1117/12.2033320

KEYWORDS: Bioluminescence, Tomography, Tissue optics, Tissues, Absorption, Cameras, Statistical analysis, Optical properties, Scattering, Imaging systems

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Proceedings Article | 14 June 2013 Paper

Random matrix-based dimensionality reduction for bioluminescence tomography reconstruction

Iain Styles, Hector Basevi, James Guggenheim, Hamid Dehghani

Proceedings Volume 8799, 87990J (2013) https://doi.org/10.1117/12.2033299

KEYWORDS: Bioluminescence, Tomography, Sensors, Reconstruction algorithms, Computer simulations, Inverse problems, Finite element methods, Matrix multiplication, Computed tomography, Neodymium

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Proceedings Article | 14 June 2013 Paper

Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging

James Guggenheim, Hector Basevi, Iain Styles, Jon Frampton, Hamid Dehghani

Proceedings Volume 8799, 87990G (2013) https://doi.org/10.1117/12.2033317

KEYWORDS: Tomography, Bioluminescence, Imaging systems, 3D image reconstruction, Light sources, Biomedical optics, 3D image processing, Biological research, Luminescence, Data modeling

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Proceedings Article | 15 June 2011 Paper

Development of a multi-view multi-spectral bioluminescence tomography small animal imaging system

James Guggenheim, Hamid Dehghani, Hector Basevi, Iain Styles, Jon Frampton

Proceedings Volume 8088, 80881K (2011) https://doi.org/10.1117/12.889863

KEYWORDS: Imaging systems, Mirrors, Data modeling, Finite element methods, Sensors, 3D modeling, Animal model studies, Bioluminescence, Optical properties, Tomography

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Showing 5 of 25 publications

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