We are investigating the use of nanoscale imaging technologies that might help in the fundamental
understanding of cell function and lead to early diagnosis of diseases at a single cell and molecular level.
A new method has been developed that integrates nanoimprint lithography directly with biological materials to
create replica cell impressions in robust storage medium to facilitate topographical analysis using Atomic Force
Microscopy. Termed BioimprintTM, soft lithography techniques are used to transfer precise cell topography into
polymeric composite for imaging in harsh probing or electron beam environments. By creating a permanent biological
print that is captured in a specific moment of time, a recorded response of cellular events can be stored.
The high resolution transfer of this process is illustrated by imaging membrane morphological structures consist
with exocytosis, in pituitary cells. The integration of soft lithography and biological materials presents a novel method
for the study and detection of biological systems at the nano scale. Applications of this technique to cancer cells has also