Our group conducts interdisciplinary research in the field of preclinical near-infrared fluorescence and optoacoustic imaging. We apply our extensive methodological expertise in data acquisition and post-processing to investigate models of brain diseases, with a focus on cerebral ischemia and Alzheimer`s disease. To this end, we use experimental and genetic animals models of human disease, pharmacology, biochemical and immunohistochemical techniques are employed for validation of these approaches.
Automated registration of magnetic resonance imaging and optoacoustic tomography data for experimental studies
Noninvasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography
Non-invasive detection of matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral optoacoustic tomography
Quantification of amyloid deposits and oxygen extraction fraction in the brain with multispectral optoacoustic imaging in arcAbeta mouse model of Alzheimer's disease
Reconstructing optical parameters from double-integrating-sphere measurements using a genetic algorithm