A novel omnidirectional endoscope which covers a field-of-view of ±135° away from the optical axis and 360°
panoramically (3π steradians) can significantly improve the visual reality for in-vivo minimally invasive surgery and
diagnostics. The inventive integration of a wide angle objective lens and catadioptric optics provides an omnidirectional
viewing angle without severe optical distortion. Optical fibers/LEDs are used for illumination of the entire field-of-view.
The omnidirectional viewing capability of this endoscope enables the user to visualize and relate positions in the entire
operating field eliminating the need for registration when using multiple scopes. It also prevents repetitive insertions of
conventional endoscopes with different direction of view and reduces the risk of misguidance due to the limited field-of-view
of conventional endoscopes.
Tuberculosis (TB) remains the leading cause of death in the world from a single infectious disease, and the threat is becoming more critical with the spread of multi-drug resistant Tuberculosis (MDR-TB). TB detection, and susceptibility testing for drug resistant strain identification, is advancing with the development of Luciferase Reporter Mycobacteriophages (LRM). LRM will emit visible light at very low intensity when in the presence of live mycobacteria cells such as Tuberculosis strains. InterScience, Inc., together with its collaboration, is developing a highly sensitive, real-time digital detection system for the analysis of luminescent assays. Recent advances in system sensitivity, design, and implementation, as well as preliminary results of the development of individual test cartridges, will be presented. The ultimate goal of this work is to provide a versatile luminescence detection tool for widespread research and clinical applications.