Dr. Jessie R. Weber Profile

Dr. Jessie R. Weber

Research Scientist at Coractive

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Publications (3)

SPIE Journal Paper | 27 October 2020 Open Access

Experimental validation of a spectroscopic Monte Carlo light transport simulation technique and Raman scattering depth sensing analysis in biological tissue

Alireza Akbarzadeh, Ehsan Edjlali, Guillaume Sheehy, Juliette Selb, Rajeev Agarwal, Jessie Weber, Frédéric Leblond

JBO, Vol. 25, Issue 10, 105002, (October 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.10.105002

KEYWORDS: Raman spectroscopy, Raman scattering, Scattering, Photons, Absorption, Tissue optics, Luminescence, Monte Carlo methods, Optical properties, Light scattering

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Significance: Raman spectroscopy (RS) applied to surgical guidance is attracting attention among scientists in biomedical optics. Offering a computational platform for studying depth-resolved RS and probing molecular specificity of different tissue layers is of crucial importance to increase the precision of these techniques and facilitate their clinical adoption. Aim: The aim of this work was to present a rigorous analysis of inelastic scattering depth sampling and elucidate the relationship between sensing depth of the Raman effect and optical properties of the tissue under interrogation. Approach: A new Monte Carlo (MC) package was developed to simulate absorption, fluorescence, elastic, and inelastic scattering of light in tissue. The validity of the MC algorithm was demonstrated by comparison with experimental Raman spectra in phantoms of known optical properties using nylon and polydimethylsiloxane as Raman-active compounds. A series of MC simulations were performed to study the effects of optical properties on Raman sensing depth for an imaging geometry consistent with single-point detection using a handheld fiber optics probe system. Results: The MC code was used to estimate the Raman sensing depth of a handheld fiber optics system. For absorption and reduced scattering coefficients of 0.001 and 1 mm − 1, the sensing depth varied from 105 to 225 μm for a range of Raman probabilities from 10 − 6 to 10 − 3. Further, for a realistic Raman probability of 10 − 6, the sensing depth ranged between 10 and 600 μm for the range of absorption coefficients 0.001 to 1.4 mm − 1 and reduced scattering coefficients of 0.5 to 30 mm − 1. Conclusions: A spectroscopic MC light transport simulation platform was developed and validated against experimental measurements in tissue phantoms and used to predict depth sensing in tissue. It is hoped that the current package and reported results provide the research community with an effective simulating tool to improve the development of clinical applications of RS.

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Proceedings Article | 19 April 2017 Presentation

New fiber-based approaches for optical biopsy (Conference Presentation)

Jessie Weber, Christophe Rivière, Antoine Proulx, Pascal Gallant, Ozzy Mermut

Proceedings Volume 10058, 1005805 (2017) https://doi.org/10.1117/12.2252636

KEYWORDS: Indium oxide, Sensors, Biopsy, Tissue optics, Diagnostics, Fiber optics, Optical testing, Pathology, Tissues, Optical fibers

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SPIE Journal Paper | 1 January 2011 Open Access

Multispectral imaging of tissue absorption and scattering using spatial frequency domain imaging and a computed-tomography imaging spectrometer

Jessie Weber, Anthony Durkin, Bruce Tromberg, David Cuccia, William Johnson, Daniel Wilson, Gregory Bearman, Mike Hsu, Alexander Lin, Devin Binder

JBO, Vol. 16, Issue 1, 011015, (January 2011) https://doi.org/10.1117/12.10.1117/1.3528628

KEYWORDS: Absorption, Scattering, Tissue optics, Tissues, Spatial frequencies, Optical properties, Multispectral imaging, Spectroscopy, Brain mapping, Brain

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