We describe a multispectral continuous-wave diffuse optical tomography (DOT) system that can be used for <i>in vivo</i> three-dimensional (3-D) imaging of seizure dynamics. Fast 3-D data acquisition is realized through a time multiplexing approach based on a parallel lighting configuration - our system can achieve 0.12ms per source per wavelength and up to 14Hz sampling rate for a full set of data for 3-D DOT image reconstruction. The system is validated using both static and dynamic tissue-like phantoms. <i>In vivo</i> rat experiments using both focal and generalized models of seizure are also demonstrated. In the focal seizure experiment, hemodynamic seizure focus was clearly detected and tracked. In the generalized seizure experiment, early hemodynamic responses with heterogeneous patterns were detected several minutes preceding the EEG onset of seizures and widespread hemodynamic changes were found evolving from local regions. Connectivity changes were also found during the development of seizures. This study demonstrates that DOT represents a powerful tool for investigating seizure generation and propagation, elucidating the causes and mechanism of seizures.
The requirements for ITO glass used in OLED are higher than those for LCD used. It has to keep much strict control on the process for making ITO glass because of the numerous impact factors. An orthogonal analysis method is used to deal with those factors, and the ITO glass good enough for OLED used by the DC magnetron sputtering has been got. The glass properties are 17Ω/, 81% transmittance in visible region. By the orthogonal analysis method, we just use limited materials and take experiment times to finish the crafts research.