Diabetes has been a serious problem that poses threat to people's health all around the world. It is still a challenge for us to detect blood glucose concentration continuously and non-invasively. In this research, we developed a free-space spectrum domain optical coherence tomography (SD-OCT) system for non-invasive blood glucose detection which possessed advantages of easy construction, analyzation and control. In this system, a laser with center wavelength of 980nm was applied because of its low absorption in both glucose and water, which was suitable for OCT imaging. However, the laser with wavelength of 980nm was not used in the OCT with optic fiber type which was commercially designed for wavelengths of 830nm, 1310nm and 1550nm. By applying a dispersing prism, we could obtain higher resolution spectrum to acquire better OCT images and more accurate glucose concentration. The tomography function of this free-space SD-OCT system was proved to work by scanning onion sample. Pristella maxillaris is a kind of fish with transparent body structure and suitable size, thus we consider it to be an ideal animal for blood glucose measurement by optical methods. We cultivated pristella maxillaris, an ideal fish for this experiment, in glucose solutions with five different concentrations as samples to study glucose monitoring. The OCT signals of the five groups correlated respectively to the glucose concentrations. Therefore, our method provided the potential for measuring blood glucose concentration non-invasively.
Binary optics has been interested widely in recent years, where the optical element can be fabricated on a thin glass plate with micro-ion-etching film layer. A novel optical scanning system for gene disease diagnostics is developed in this paper, where four kinds optical devices are used, such as beam arrays splitter, arrays lens, filter arrays element and detection arrays. A soft for binary device designing with iterative method is programmed. Two beam arrays splitters are designed and fabricated, where one devices can divide a beam into the 9x9 arrays , the other will divide a beam into the 13x13 arrays. The beam arrays splitter has a good diffraction efficiency >70%, and an even energy distribution. The gene disease diagnostics system is portable by biochip and binary optics technology.
Laboratory-on-a-chip has been interested widely in recent years, where the sample preparation, bio-chemical reaction, separation, detection and analysis, are performed in a small biochip which is only a fingernall dimension. In order to obtain a high detection sensitivity 1 fluors/micrometers <SUP>2</SUP> (one fluorescence molecular per square micrometer) in biochip scanning system, it is required that the scanning objective lens is a big numerical aperture (> 0.5), very small focal spot (< 5 micrometers ) and long back focal length (> 3 mm). In this paper, a combined lens is designed for the scanning objective lens, which is with big numerical aperture NA > 0.7, very small focal spot (< 2 micrometers ) and long back focal length (> 3 mm). The phase aberrations of combined lens, including the aspherical aberration and the chromatic aberration corresponding to wavelength 532 nm, 570 nm, 635 nm, 670 nm, are corrected very well. The encircled energy diagram of the lens is good to the diffraction limit. The focal spot diagram, the optical path difference diagram, the transverse ray fan plot and the modulation transfer function, are studied also. A novel confocal scanning system of biochip with the designed combined lens as the objective lens is developed, some experiment results in a multi-channel biochip are obtained.
A multichannel joint transform correlator, using a Dammann grating as a beam-splitter to split one incident beam up into 2D array of equal intensity beams to form multichannel for correlation, is presented and investigated. Mathematical analysis and optical experimental results are presented.