This paper focuses on the recent status of art technology of a virtual instrumentation - a virtual microscope (VM) and its
wide applications in telepathology, teaching, training, research, and internet activities with digitalized slides. Firstly, the
current status for virtual microscope is reviewed; and then various native methods and algorithms, particular a 3-D
virtual slide scanning and presentation, for a virtual microscope is presented and discussed; experiments of various
applications are taken and analyzed; and finally, solution of a new virtual instrumentation and technology for
pathologists are proposed and summarized.