With the debut of antibiotic drug therapy, and as a result of its ease of use and general success in treating infection,
drugs have become the treatment of choice for most bacterial infections. However, the advent of multiple, very
aggressive drug-resistant bacteria, an increasing population which cannot tolerate drugs, and the high cost of drug
therapy suggest that a new modality for treating infections is needed. The complex interplay of clonal spread,
persistence, transfer of resistance elements and cell-to-cell interaction all contribute to the difficulty in developing drugs
to treat new antibiotic-resistant bacterial strains.
A dynamic non-drug system, using extant pulsed ultraviolet lightwave technology to kill infection, is being developed
to destroy pathogens. This paper theorizes that the shock effect of pulsed xenon's high energy ultraviolet pulses at
wavelengths between 250-270nm separates the bacteria's DNA bands, and, subsequently, destroys them. Preliminary
laboratory tests have demonstrated the ability of the technology to destroy <i>Staphylococcus aureus, Pseudomonas
aeruginosa Escherichia coli, Helicobacter pylori, Acinetobacter baumannii, Klebsiella punemonia, Bacillus subtillis,
and Aspergillus fumigates</i> at penetration depths of greater than 3mm in fluids with 100% effectiveness in less than five
seconds of exposure to pulsed xenon lightwaves.
Micro Invasive Technology, Inc is developing .pulsed xenon therapeutic catheters and endoscopic instruments for
internal antimicrobial eradication and topographical devices for prophylactic wound, burn and surgical entrance/exit
site sterilization. Pulsed Xenon light sources have a broad optical spectrum (190-1200nm), and can generate light
pulses with sufficient energy for combined imaging and therapeutic intervention by multiplexing a fiber optic pathway
into the body. In addition, Pulsed Xenon has proven ability to activate photo reactive dyes; share endoscopic
lightguides with lasers while, simultaneously, capturing high quality visual and activated video images.
Today's optical designers face new corporate cultures whose priorities include product performance as only one criteria for success. Designers must also address cost constraints, new and unfamiliar skill requirements, overhead containment, maintenance of profit margins, and staff reductions. Old skills must be applied in new ways. New diamond-turning machine technology has made it possible to construct injection molding tools which combine refraction and diffraction into a single lens element. New polymer materials render the designs to be technically and commercially feasible. The significance of combining refraction and diffraction in a single lens element should not be underestimated, as it will expand the capability of polymer optics beyond its refractive limitations. Use of this technology can restructure domestic optical manufacturing.
Automation and polymer science represent fundamental new technologies which can be directed toward realizing the goal of establishing a domestic, world-class, commercial optics business. Use of innovative optical designs using precision polymer optics will enable the US to play a vital role in the next generation of commercial optical products. The increased cost savings inherent in the utilization of optical-grade polymers outweighs almost every advantage of using glass for high volume situations. Optical designers must gain experience with combined refractive/diffractive designs and broaden their knowledge base regarding polymer technology beyond a cursory intellectual exercise. Implementation of a fully automated assembly system, combined with utilization of polymer optics, constitutes the type of integrated manufacturing process which will enable the US to successfully compete with the low-cost labor employed in the Far East, as well as to produce an equivalent product.