Dr. Julien Bec Profile

Dr. Julien Bec

Director of Engineering at Univ of California Davis

SPIE Involvement:

Author

Area of Expertise:

Photonics , Instrument design , Regulatory , Manufacturing , Clinical validation , Mechatronics

Websites:

Company Website

Profile Summary

After an early career as an R&D engineer in the automotive industry, Julien Bec joined the UC Davis Biomedical Engineering department working on the design, fabrication, and evaluation of biomedical imaging systems in the nuclear and optical imaging fields. His current activity is focused on the development and clinical validation of fluorescence lifetime instrumentation for cardiovascular and image-guided surgical oncology applications.

Publications (44)

Proceedings Article | 13 March 2024 Presentation

Presentation

Assessing in vivo label-free fluorescence lifetime Imaging sensitivity to low-grade colon inflammation

Alba Alfonso García, Jee-Yon Lee, Alex Condon, Xiangnan Zhou, Julien Bec, Andreas Baumler, Laura Marcu

Proceedings Volume PC12822, PC1282206 (2024) https://doi.org/10.1117/12.3002008

KEYWORDS: Colon, Inflammation, In vivo imaging, Fluorescence lifetime imaging, Tissues, Mode conditioning cables, Switches, Reliability, Portability, Micro optics

Read Abstract +

Proceedings Article | 13 March 2024 Presentation

Presentation

Demonstration of a combined multispectral FLIm/polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions

Julien Bec, Xiangnan Zhou, Martin Villiger, Brett Bouma, Laura Marcu

Proceedings Volume 12819, 1281908 (2024) https://doi.org/10.1117/12.3003560

KEYWORDS: Optical coherence tomography, Atherosclerosis, Imaging systems, Polarization, Imaging devices, Visualization, Tissues, Pathogens, Natural surfaces, Modulation

Read Abstract +

Proceedings Article | 13 March 2024 Presentation

Presentation

Mesoscopic FLIm for detection of residual cancer in transoral robotic surgery

Mohamed Hassan, Brent Weyers, Julien Bec, Jinyi Qi, Dorina Gui, Arnaud Bewley, Marianne Abouyared, Andrew Birkeland, Laura Marcu

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3003627

KEYWORDS: Cancer, Tumor growth modeling, Robotic surgery, Data modeling, Cancer detection, Tumors, Tissues, Surgery, Cross validation, Resection

Read Abstract +

Proceedings Article | 13 March 2024 Presentation

Presentation

Optical biopsy of brain tumors using fluorescence lifetime imaging (FLIm)

Silvia Noble Anbunesan, Alba Alfonso Garcia, Julien Bec, Mohamed Hassan, Lisanne Kraft, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu

Proceedings Volume PC12831, PC1283101 (2024) https://doi.org/10.1117/12.3001898

KEYWORDS: Biopsy, Brain, Tumors, Neuroimaging, Fluorescence lifetime imaging, Tissues, Magnetic resonance imaging, Brain tissue, Windows, Tissue optics

Read Abstract +

Proceedings Article | 13 March 2024 Presentation

Presentation

Investigating fluorescence lifetime signatures for normal tissue adjacent to cancer in oropharyngeal squamous cell carcinomas

Katjana Ehrlich, Kelsey Hadfield, Lisanne Kraft, Mohamed Hassan, Brent Weyers, Xiangnan Zhou, Julien Bec, Dorina Gui, Arnaud Bewley, Marianne Abouyared, D. Gregory Farwell, Andrew Birkeland, Laura Marcu

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3003488

KEYWORDS: Tissues, Fluorescence, Cancer, Neck, Head, Tumors, Resection, Collagen, Windows, Time resolved spectroscopy

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Presentation

Demonstration of a combined multispectral FLIm/ polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions.

Julien Bec, Xiangnan Zhou, Pelham Keahey, Martin Villiger, Brett Bouma, Laura Marcu

Proceedings Volume PC12355, PC1235505 (2023) https://doi.org/10.1117/12.2649672

KEYWORDS: Optical coherence tomography, Polarization, Multispectral imaging, Imaging systems, Imaging devices, Visualization, Tissues, Reflectivity, Pathogens, Optical fibers

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Presentation

Anatomy-specific classification models using FLIm for head & neck cancer surgical guidance

Mohamed Hassan, Brent Weyers, Julien Bec, Farzad Fereidouni, Jinyi Qi, Dorina Gui, Andrew Birkeland, Arnaud Bewley, Marianne Abouyared, D. Gregory Farwell, Laura Marcu

Proceedings Volume 12354, 123540D (2023) https://doi.org/10.1117/12.2651235

KEYWORDS: Tumor growth modeling, Neck, Head, Cancer, Tongue, Tissues, Surgery, Physiology, Oncology, Lymphatic system

Read Abstract +

Proceedings Article | 6 March 2023 Presentation

Presentation

Photon economy of pulse-sampling vs TCSPC fluorescence lifetime imaging

Xiangnan Zhou, Julien Bec, Laura Marcu

Proceedings Volume PC12370, PC1237005 (2023) https://doi.org/10.1117/12.2650311

KEYWORDS: Fluorescence lifetime imaging, Sensors, Photodetectors, Luminescence, In vivo imaging, Tissues, Surgery, Pulsed laser operation, Photonic nanostructures, Laser systems engineering

Read Abstract +

Proceedings Article | 6 March 2023 Presentation + Paper

Presentation + Paper

Intraoperative detection of IDH-mutant glioma subtype using fluorescence lifetime imaging

Silvia Noble Anbunesan, Alba Alfonso-Garcia, Xiangnan Zhou, Julien Bec, Matthew Bobinski, Han Sung Lee, Lee-way Jin, Orin Bloch, Laura Marcu

Proceedings Volume 12368, 1236803 (2023) https://doi.org/10.1117/12.2650379

KEYWORDS: Tumors, Tissues, Resection, White matter, Fluorescence, Fluorescence lifetime imaging, Surgery, Medicine, Brain tissue, Brain

Read Abstract +

SPIE Journal Paper | 21 July 2022 Open Access

Open Access

Dual-modality fluorescence lifetime imaging-optical coherence tomography intravascular catheter system with freeform catheter optics

Cai Li, Julien Bec, Xiangnan Zhou, Laura Marcu

JBO, Vol. 27, Issue 07, 076005, (July 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.076005

KEYWORDS: Optical coherence tomography, Luminescence, Ultraviolet radiation, Freeform optics, Infrared imaging, Imaging systems, Collimators, Tomography, Arteries, UV optics

Read Abstract +

Proceedings Article | 9 March 2022 Presentation

Presentation

Investigating sources of FLIm data variability in head & neck cancer

Brent Weyers, Julien Bec, Athena Tam, Mohamed Hassan, Sukhkaran Aulakh, Dorina Gui, Andrew Birkeland, Arnaud Bewley, Marianne Abouyared, D. Gregory Farwell, Laura Marcu

Proceedings Volume PC11949, PC1194902 (2022) https://doi.org/10.1117/12.2609864

KEYWORDS: Tissues, Cancer, Medical imaging, In vivo imaging, Statistical analysis, Machine learning, Tumors, Tongue, Patents, Neck

Read Abstract +

Proceedings Article | 9 March 2022 Presentation

Presentation

Real-time interrogation of brain tumors using intraoperative FLIm

Silvia Noble Anbunesan, Alba Alfonso García, Xiangnan Zhou, Julien Bec, Roberto Frusciante, Lisanne Kraft, Brent Weyers, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu

Proceedings Volume PC11949, PC1194904 (2022) https://doi.org/10.1117/12.2610424

KEYWORDS: Tumors, Brain, Tissues, Neuroimaging, Luminescence, Surgery, Statistical analysis, Pulsed laser operation, Proteins, Laser tissue interaction

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Presentation

Real-time intraoperative fluorescence lifetime imaging of 5-ALA induced PpIX and autofluorescence in brain tumors: first results in patients

Xiangnan Zhou, Silvia Anbunesan, Alba Alfonso García, Julien Bec, Lisanne Kraft, Roberto Frusciante, Orin Bloch, Laura Marcu

Proceedings Volume PC11943, PC1194305 (2022) https://doi.org/10.1117/12.2612597

KEYWORDS: Tumors, Brain, Luminescence, Fluorescence lifetime imaging, Neuroimaging, Visualization, Tissues, Surgery, Video, System identification

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Presentation

Evaluation of a high-performance FLIm/OCT catheter system for biochemical and structural evaluation of atherosclerosis

Julien Bec, Cai Li, Xiangnan Zhou, Deborah Vela, Laura Marcu

Proceedings Volume PC11936, PC1193604 (2022) https://doi.org/10.1117/12.2607844

Read Abstract +

SPIE Journal Paper | 2 February 2022 Open Access

Open Access

First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence

Alba Alfonso García, Xiangnan Zhou, Julien Bec, Silvia Anbunesan, Farzad Fereidouni, Lee-Way Jin, Han Sung Lee, Orin Bloch, Laura Marcu

JBO, Vol. 27, Issue 02, 020501, (February 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.2.020501

KEYWORDS: Luminescence, Tumors, Tissues, Brain, Microscopes, In vivo imaging, Surgery, Video, Data acquisition, Visualization

Read Abstract +

Significance: 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is currently used for image-guided glioma resection. Typically, this widefield imaging method highlights the bulk of high-grade gliomas, but it underperforms at the infiltrating edge where PpIX fluorescence is not visible to the eyes. Fluorescence lifetime imaging (FLIm) has the potential to detect PpIX fluorescence below the visible detection threshold. Moreover, simultaneous acquisition of time-resolved nicotinamide adenine (phosphate) dinucleotide [NAD(P)H] fluorescence may provide metabolic information from the tumor environment to further improve overall tumor detection. Aim: We investigate the ability of pulse sampling, fiber-based FLIm to simultaneously image PpIX and NAD(P)H fluorescence of glioma infiltrative margins in patients. Approach: A mesoscopic fiber-based point-scanning FLIm device (355 nm pulses) was used to simultaneously resolve the fluorescence decay of PpIX (629/53 nm) and NAD(P)H (470/28 nm). The FLIm device enabled data acquisition at room light and rapid (<33 ms) augmentation of FLIm parameters on the surgical field-of-view. FLIm measurements from superficial tumors and tissue areas around the resection margins were performed on three glioblastoma patients in vivo following inspection of PpIX visible fluorescence with a conventional neurosurgical microscope. Microbiopsies were collected from FLIm imaged areas for histopathological evaluation. Results: The average lifetime from PpIX and NAD(P)H fluorescence distinguished between tumor and surrounding tissue. FLIm measurements of resection margins presented a range of PpIX and NAD(P)H lifetime values (τPpIX   ∼ 3 to 14 ns, τNAD(P)H = 3 to 6 ns) associated with unaffected tissue and areas of low-density tumor infiltration. Conclusions: Intraoperative FLIm could simultaneously detect the emission of PpIX and NAD(P)H from patients in vivo during craniotomy procedures. This approach doubles as a clinical tool to identify tumor areas while performing tissue resection and as a research tool to study tumor microenvironmental changes in vivo. Intraoperative FLIm of 5-ALA-induced PpIX and tissue autofluorescence makes a promising surgical adjunct to guide tumor resection surgery.

Proceedings Article | 3 August 2021 Paper

Paper

Controlling light penetration depth to amplify the gain in ultra-fast silicon APDs and SPADs using photon-trapping nanostructures

Ahasan Ahamed, Cesar Bartolo-Perez, Ahmed Sulaiman Mayet, Soroush GhandiParsi, Xiangnan Zhou, Julien Bec, Nibir K. Dhar, Ekaterina P. Devine, Shih-Yuan Wang, Gerard Ariño-Estrada, Laura Marcu, M. Saif Islam

Proceedings Volume 11800, 118000F (2021) https://doi.org/10.1117/12.2597835

KEYWORDS: Absorption, Silicon, Avalanche photodetectors, Photonic nanostructures, Nanostructures, Avalanche photodiodes, Etching, Photonic devices, Photodiodes, Sensors

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Label-free assessment of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime

Julien Bec, Deborah vela, L. Maximilian Buja, Kenneth Margulies, Laura Marcu

Proceedings Volume 11621, 116210N (2021) https://doi.org/10.1117/12.2579155

KEYWORDS: Luminescence, Ultraviolet radiation, Tissues, Spectroscopy, Optical coherence tomography, Multispectral imaging, Intravascular ultrasound, Imaging systems, Imaging spectroscopy, Foam

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Head and neck cancer visualization using deep learning combined with fluorescence lifetime imaging and white light imaging

Takanori Fukazawa, Mark Marsden, Brent Weyers, Yu-Cheng Deng, Julien Bec, D. Gregory Farwell, Laura Marcu

Proceedings Volume 11631, 116310O (2021) https://doi.org/10.1117/12.2581449

KEYWORDS: Tumors, Visualization, Fluorescence lifetime imaging, Cancer, Algorithm development, Tissues, Surgery, Sensor fusion, Pathology, Optical sensors

Read Abstract +

Proceedings Article | 5 March 2021 Presentation + Paper

Presentation + Paper

Intraoperative margin assessment in head and neck cancer using label-free fluorescence lifetime imaging, machine learning and visualization

Mark Marsden, Brent Weyers, Takanori Fukazawa, Tianchen Sun, Julien Bec, Regina Gandour-Edwards, Dorina Gui, Andrew Birkeland, Arnaud Bewley, Marianne Abouyared, D. Gregory Farwell, Laura Marcu

Proceedings Volume 11631, 116310N (2021) https://doi.org/10.1117/12.2577051

KEYWORDS: Cancer, Visualization, Machine learning, Neck, Head, Fluorescence lifetime imaging, Tissues, Tongue, Tissue optics, Signal to noise ratio

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Intraoperative FLIm for pathology detection and surgical guidance in oral and oropharyngeal cancer patients

Brent Weyers, Mark Marsden, Julien Bec, Takanori Fukazawa, Roberto Frusciante, Athena Tam, Dorina Gui, Andrew Birkeland, Marianne Abouyared, Arnaud Bewley, Regina Gandour-Edwards, John Hanks, D. Gregory Farwell, Laura Marcu

Proceedings Volume 11631, 116310V (2021) https://doi.org/10.1117/12.2576804

KEYWORDS: Cancer, Tumors, Pathology, Tissues, Luminescence, Tongue, Surgery, In vivo imaging, Imaging devices, Fluorescence lifetime imaging

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Stereo reconstruction and 3D rendering for intraoperative fluorescence lifetime imaging visualization

Tianchen Sun, Julien Bec, Mark Marsden, Jakob Unger, Kwan-Liu Ma, Laura Marcu

Proceedings Volume 11631, 116310X (2021) https://doi.org/10.1117/12.2579009

KEYWORDS: Visualization, Fluorescence lifetime imaging, 3D visualizations, Surgery, 3D modeling, Reconstruction algorithms, Clouds, Tumors, Tissues, Robotics

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

High performance FLIm/OCT catheter system compatible for biochemical/structural evaluation of atherosclerosis

Cai Li, Julien Bec, Xiangnan Zhou, Laura Marcu

Proceedings Volume 11621, 116210P (2021) https://doi.org/10.1117/12.2577322

KEYWORDS: Optical coherence tomography, Solid state electronics, Integrated optics, Collimators, Tissues, Spectroscopy, Sensors, Microchannel plates, Light emitting diodes

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Assessment of murine gut dysbiosis with intraluminal fluorescence lifetime imaging

Alba Alfonso García, Stephanie Cevallos, Jee-Yon Lee, Cai Li, Julien Bec, Andreas Bäumler, Laura Marcu

Proceedings Volume 11626, 116260I (2021) https://doi.org/10.1117/12.2578687

KEYWORDS: Tissues, Fluorescence lifetime imaging, Colon, Mode conditioning cables, Luminescence, Switches, Sodium, Inflammation, In vivo imaging, Diagnostics

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Multispectral fluorescence lifetime imaging system with Si avalanche photodetector: a better platform for clinical application

Xiangnan Zhou, Julien Bec, Diego Yankelevich, Laura Marcu

Proceedings Volume 11631, 116310E (2021) https://doi.org/10.1117/12.2579121

KEYWORDS: Imaging systems, Multispectral imaging, Fluorescence lifetime imaging, Avalanche photodetectors, Silicon, Tissues, Luminescence, Ultraviolet radiation, Tumors

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

Presentation

Visualization and quantification of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime (Conference Presentation)

Julien Bec, Deborah Vela, Jennifer Phipps, Michael Agung, Jakob Unger, Ken Margulies, Maximilian Buja, Laura Marcu

Proceedings Volume 11215, 112150E (2020) https://doi.org/10.1117/12.2546921

KEYWORDS: Luminescence, Microsoft Foundation Class Library, Visualization, Intravascular ultrasound, Arteries, Imaging systems, In vivo imaging, Fluorescence lifetime imaging, Tissues, Biological research

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

Presentation

Novel broadband freeform micro-optics for multimodal FLIm-OCT intravascular catheter (Conference Presentation)

Julien Bec, Cai Li, Laura Marcu

Proceedings Volume 11215, 112150H (2020) https://doi.org/10.1117/12.2544488

KEYWORDS: Micro optics, Optical coherence tomography, UV optics, GRIN lenses, Near ultraviolet, Optics manufacturing, Fluorescence lifetime imaging, Tissues, Chromatic aberrations, Reflectivity

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

Presentation

Fluorescence Lifetime Imaging (FLIm) for intraoperative pathology detection in transoral robotic surgery (Conference Presentation)

Brent Weyers, Mark Marsden, Tianchen Sun, Julien Bec, Arnaud Bewley, Regina Gandour-Edwards, Michael Moore, D. Gregory Farwell, Laura Marcu

Proceedings Volume 11229, 1122902 (2020) https://doi.org/10.1117/12.2545150

KEYWORDS: Tissues, Pathology, Fluorescence lifetime imaging, Robotic surgery, Cancer, Tumors, Surgery, Visualization, Endoscopy, Robotics

Read Abstract +

Proceedings Article | 7 March 2019 Presentation

Presentation

Study of vascular tissue grafts cellularization process in bioreactors using label-free fluorescence lifetime imaging (Conference Presentation)

Cai Li, James Mcmasters, Alba Alfonso García, Julien Bec, Anne Haudenschild, Alyssa Panitch, Leigh Griffiths, Laura Marcu

Proceedings Volume 10855, 108550A (2019) https://doi.org/10.1117/12.2510823

KEYWORDS: Tissues, Fluorescence lifetime imaging, Nondestructive evaluation, Control systems, Manufacturing, Multispectral imaging, Stem cells, Prototyping

Read Abstract +

Proceedings Article | 7 March 2019 Presentation

Presentation

Real-time delineation of cancer margins in otolaryngologic applications using multispectral FLIm (Conference Presentation)

Brent Weyers, Tianchen Sun, Jakob Unger, Hanna Kim, Julien Bec, Michael Moore, Arnaud Bewley, Gregory Farwell, Laura Marcu

Proceedings Volume 10868, 108680L (2019) https://doi.org/10.1117/12.2506795

KEYWORDS: Cancer, Tissues, Tumors, Pathology, Fiber optics, Time resolved spectroscopy, In vivo imaging, Tongue

Read Abstract +

Proceedings Article | 7 March 2019 Presentation

Presentation

Fluorescence lifetime imaging and intravascular ultrasound (FLIm/IVUS) platform for label-free intraluminal characterization of vascular biomaterials in vitro and in vivo (Conference Presentation)

Alba Alfonso García, Anne Haudenschild, James Mcmasters, Julien Bec, Xiangnan Zhou, Alyssa Panitch, Leigh Griffiths, Laura Marcu

Proceedings Volume 10855, 1085509 (2019) https://doi.org/10.1117/12.2510816

KEYWORDS: In vivo imaging, In vitro testing, Fluorescence lifetime imaging, Arteries, Tissues, Intravascular ultrasound, Structured optical fibers, Multispectral imaging, Imaging systems, Natural surfaces

Read Abstract +

Proceedings Article | 5 April 2018 Presentation

Presentation

Multichannel solid state photodetection system for low-cost fluorescence lifetime spectroscopy (Conference Presentation)

Diego Yankelevich, Julien Bec, Jonathan Wapman, Laura Marcu

Proceedings Volume 10484, 104840H (2018) https://doi.org/10.1117/12.2291180

KEYWORDS: Luminescence, Photodetectors, Fluorescence spectroscopy, Spectroscopy, Solid state physics, Capacitors, Laser beam diagnostics, Microchannel plates, Optical fibers, Tissues

Read Abstract +

Proceedings Article | 19 April 2017 Presentation

Presentation

Fluorescence lifetime intravascular ultrasound (FLIm-IVUS) and the quest to discriminate between early and advanced lipid cores in atherosclerosis (Conference Presentation)

Jennifer Phipps, Julien Bec, Deborah Vela, L. Maximilian Buja, Jeffrey Southard, Kenneth Margulies, Laura Marcu

Proceedings Volume 10042, 100420C (2017) https://doi.org/10.1117/12.2253185

KEYWORDS: Imaging systems, Heart, Intravascular ultrasound, Luminescence, Fluorescence lifetime imaging, Arteries, Foam, Ultrasonography, Calcium, Diagnostics and therapeutics

Read Abstract +

Proceedings Article | 19 April 2017 Presentation

Presentation

Autofluorescence lifetime imaging during transoral robotic surgery: a clinical validation study of tumor detection (Conference Presentation)

João Lagarto, Jennifer Phipps, Jakob Unger, Leta Faller, Dimitris Gorpas, Dinglong Ma, Julien Bec, Michael Moore, Arnaud Bewley, Diego Yankelevich, Jonathan Sorger, Gregory Farwell, Laura Marcu

Proceedings Volume 10039, 100390E (2017) https://doi.org/10.1117/12.2253226

KEYWORDS: Tumors, Imaging systems, Biological detection systems, Tissues, In vivo imaging, Robotic surgery, Fiber optics, Surgery, Spectroscopes, Fiber optics tests

Read Abstract +

Proceedings Article | 19 April 2017 Presentation

Presentation

Three-dimensional online surface reconstruction of augmented fluorescence lifetime maps using photometric stereo (Conference Presentation)

Jakob Unger, Joao Lagarto, Jennifer Phipps, Dinglong Ma, Julien Bec, Jonathan Sorger, Gregory Farwell, Richard Bold, Laura Marcu

Proceedings Volume 10054, 100540F (2017) https://doi.org/10.1117/12.2253229

KEYWORDS: Luminescence, Natural surfaces, Tissue optics, Image segmentation, Tissues, Time resolved spectroscopy, Raster graphics, 3D modeling, Cameras, Pathology

Read Abstract +

Proceedings Article | 27 April 2016 Presentation

Presentation

Support vector machine based classification and mapping of atherosclerotic plaques using fluorescence lifetime imaging (Conference Presentation)

Hussain Fatakdawala, Dimitris Gorpas, Julien Bec, Dinglong Ma, Diego Yankelevich, John Bishop, Laura Marcu

Proceedings Volume 9689, 968934 (2016) https://doi.org/10.1117/12.2214028

KEYWORDS: Fluorescence lifetime imaging, Data modeling, Data acquisition, Classification systems, Tissues, Clinical research, Animal model studies, Library classification systems, Diagnostics, Current controlled current source

Read Abstract +

Proceedings Article | 27 April 2016 Presentation

Presentation

Combined fiber probe for fluorescence lifetime and Raman spectroscopy (Conference Presentation)

Sebastian Dochow, Dinglong Ma, Ines Latka, Thomas Bocklitz, Brad Hartl, Julien Bec, Hussain Fatakdawala, Sebastian Wachsmann-Hogiu, Eric Marple, Kirk Urmey, Michael Schmitt, Laura Marcu, Jürgen Popp

Proceedings Volume 9698, 969806 (2016) https://doi.org/10.1117/12.2214151

KEYWORDS: Raman spectroscopy, Luminescence, In vivo imaging, Tissues, Biomedical optics, Raster graphics, Diagnostics, Biological research, Spectroscopy, Fiber optics

Read Abstract +

Proceedings Article | 13 April 2016 Presentation + Paper

Presentation + Paper

Online multispectral fluorescence lifetime values estimation and overlay onto tissue white-light video frames

Dimitris Gorpas, Dinglong Ma, Julien Bec, Diego Yankelevich, Laura Marcu

Proceedings Volume 9696, 969609 (2016) https://doi.org/10.1117/12.2213895

KEYWORDS: Luminescence, Tissues, Image segmentation, Video, Fluorescence lifetime imaging, Augmented reality, Real time imaging, Data acquisition, RGB color model, Tissue optics, Time resolved spectroscopy, Cameras, Raster graphics

Read Abstract +

Proceedings Article | 26 February 2015 Paper

Paper

In-vivo validation of fluorescence lifetime imaging (FLIm) of coronary arteries in swine

Julien Bec, Dinglong Ma, Diego Yankelevich, Dimitris Gorpas, William Ferrier, Jeffrey Southard, Laura Marcu

Proceedings Volume 9303, 93033M (2015) https://doi.org/10.1117/12.2079833

KEYWORDS: In vivo imaging, Imaging systems, Luminescence, Data acquisition, Arteries, Francium, Fluorescence lifetime imaging, Optical fibers, Blood, Fluorescent markers

Read Abstract +

SPIE Journal Paper | 4 June 2014 Open Access

Open Access

Rotational multispectral fluorescence lifetime imaging and intravascular ultrasound: bimodal system for intravascular applications

Dinglong Ma, Julien Bec, Diego Yankelevich, Dimitris Gorpas, Hussain Fatakdawala, Laura Marcu

JBO, Vol. 19, Issue 06, 066004, (June 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.6.066004

KEYWORDS: Intravascular ultrasound, Luminescence, Imaging systems, Arteries, Data acquisition, Signal to noise ratio, Multispectral imaging, Fiber optics, Fluorescence lifetime imaging, Transducers

Read Abstract +

Proceedings Article | 4 March 2014 Paper

Paper

Bi-modal imaging of atherosclerotic plaques: Automated method for co-registration between fluorescence lifetime imaging and intravascular ultrasound data

Dimitris Gorpas, Hussain Fatakdawala, Julien Bec, Dinglong Ma, Diego Yankelevich, John Bishop, Jinyi Qi, Laura Marcu

Proceedings Volume 8926, 892638 (2014) https://doi.org/10.1117/12.2040311

KEYWORDS: Intravascular ultrasound, Image segmentation, Luminescence, Image processing, Data acquisition, Fluorescence lifetime imaging, Image restoration, Image registration, Image filtering, Arteries

Read Abstract +

SPIE Journal Paper | 1 November 2012 Open Access

Open Access

In vivo validation of a bimodal technique combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy for diagnosis of oral carcinoma

Yang Sun, Hongtao Xie, Jing Liu, Matthew Lam, Abhijit Chaudhari, Feifei Zhou, Julien Bec, Diego Yankelevich, Allison Dobbie, Steven Tinling, Regina Gandour-Edwards, Wayne Monsky, Gregory Farwell, Laura Marcu

JBO, Vol. 17, Issue 11, 116003, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.11.116003

KEYWORDS: Tissues, Luminescence, Tumors, Collagen, In vivo imaging, Time resolved spectroscopy, Ultrasonics, Ultrasonography, Tissue optics, Transducers

Read Abstract +

SPIE Journal Paper | 1 October 2012 Open Access

Open Access

Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound

Julien Bec, Hongtao Xie, Diego Yankelevich, Feifei Zhou, Yang Sun, Narugopal Ghata, Ralph Aldredge, Laura Marcu

JBO, Vol. 17, Issue 10, 106012, (October 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.10.106012

KEYWORDS: Intravascular ultrasound, Luminescence, Blood, Fiber optics, Diagnostics, Arteries, Data acquisition, Transducers, Tissues, Imaging systems

Read Abstract +

Proceedings Article | 18 February 2011 Paper

Paper

Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy: study of an optimized blood flushing system

Narugopal Ghata, Ralph Aldredge, Julien Bec, Laura Marcu

Proceedings Volume 7883, 78833E (2011) https://doi.org/10.1117/12.874957

KEYWORDS: Blood circulation, Blood, Blood vessels, Luminescence, Fluorescence spectroscopy, Spectroscopy, Turbulence, Diagnostics, 3D modeling, Pathology

Read Abstract +

Proceedings Article | 18 February 2011 Paper

Paper

Design, construction, and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels

Julien Bec, Hongtao Xie, Diego Yankelevich, Feifei Zhou, Yang Sun, Narugopal Ghata, Ralph Aldredge, Laura Marcu

Proceedings Volume 7883, 788337 (2011) https://doi.org/10.1117/12.875095

KEYWORDS: Intravascular ultrasound, Luminescence, Blood, Fiber optics, Fluorescence spectroscopy, Transducers, Diagnostics, Francium, Data acquisition, Time resolved spectroscopy

Read Abstract +

Showing 5 of 44 publications

SIGN IN TO:

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Advertisement

Advertisement