In order to successfully implement the extended-life operation plan of the nuclear power plant (NPP), predictive maintenance based on on-line monitoring of deteriorated components becomes highly important. Pipe wall-thinning is usually caused by Flow-Accelerated Corrosion (FAC) under the undesirable combination of water chemistry, flow velocity and material composition. In order to increase the confidence of understanding on underlying process, a multi-disciplinary approach has been adopted in this work. Here, we apply a combination of several advanced sensors, ranging from chemical electrodes to mechanical vibration sensors to monitor the thickness change of the elbow, which can be still economical option. Electrochemical Corrosion Potential (ECP) and pH are chosen as electrochemical parameters, the change of vibration mode, displacement, and etc. are chosen as mechanical parameters to monitor the wall thinning phenomena. Electrodes are developed for the on-line monitoring of pH and ECP. Vibration is considered as a promising candidate as a mechanical parameter. Various sensors are surveyed and some are chosen based on FEM analysis result, which shows the approximate vibration range according to the thickness change. Mechanical sensors need to be sensitive enough to detect small thickness change with adequate safety margin to a pipe rupture. A few sensors are suggested to detect vibration or displacement quantitatively. Fiber optic sensors are chosen for their non-contacting property, which is appropriate for the high temperature application. Accelerometer and capacitance gage are suggested for their applicability fit to the test purpose.