The development of precision farming technology (e.g., precise weeding, fertilization and pesticide) requires a higher level of technical support. The use of unmanned aerial vehicle (UAV) in agriculture is an innovation and has great potential for precision farming. It is shown that for the differentiated applications in agriculture, it is most expedient to use UAV. The directions of using UAV in agriculture are considered, as they most fully meet ecological and environmental requirements and ensure the safety of modern human-machine systems. This research aims at the development of a programmable, fully autonomous or remotely controlled unmanned aerial system (UAS) that contain complexes of automatic or remotely controlled UAV for precision farming technology. The basic requirements to the quality of the technological operation for the variable rate applications with the help of unmanned aerial vehicles will be developed. We will conduct selection and justification of the main parameters of the UAV for agricultural purposes. In addition to the flight-technical characteristics of UAV, it displays the technological parameters of differentiated application for a particular field being treated. The technological process of UAV application in the system of precise farming includes sequential interrelated operations: monitoring and sounding of crops (UAV equipped with multispectral camera), obtaining, processing and transmitting information to data center for precise farming management.