We propose a screening system based on nano structure photonics crystal in homecare. Proposed system used several kinds of photonics crystal based substrates: 50nm L/S SERS substrate, 70nm L/S SERS substrate, 100nm L/S SERS substrate. Target drug in tear drop on these fabricated substrates. We confirmed the effect using Surface enhanced Raman scattering. In this study, Target drug is Phenobarbital Sodium (PB) which is an anticonvulsant agent. The results suggest a form that could enhance Raman Spectroscopy efficiently.