Prof. Kevin W. Eliceiri
RRF Walter H. Helmerich Professor Medical Physics at Morgridge Institute for Research
SPIE Involvement:
Senior Members Committee | Conference Program Committee | Author | Student Chapter Advisor
Profile Summary

Dr. Eliceiri has been conducting research on computational and optical approaches to live cell imaging for two decades, with a focus on multidimensional fluorescence approaches for cell studies and image informatics tools for image analysis. Under his NIH P41 funded “Center for Open Bioimage Analysis” (COBA) his lab develops and maintain the open-source software FIJI and ImageJ while making new deep learning tools and workflow solutions for bioimaging. A major focus of his research is to develop and apply non-invasive optical and computational approaches for understanding the role of the cellular microenvironment in normal and diseased processes. The Eliceiri lab has developed a wide range of second harmonic generation, spectral, lifetime and polarization based imaging methods for investigating cell-cell, cell-matrix and endothelial-stromal interactions and metabolism. Dr. Eliceiri and collaborators demonstrated that alignment of collagen fibers surrounding tumor epithelial cells can serve as a quantitative image-based biomarker for survival of invasive ductal breast carcinoma patients. Specific types of collagen alignment have been identified for their prognostic value in a wide range of cancers and now these tumor associated collagen signatures (TACS) are central to several clinical specimen imaging trials. The Eliceiri lab has also developed specialized open-source tools for collagen quantification that can measure not only the individual collagen fiber geometries like thickness, length, angle, and curvature but also bulk properties like global or local fiber density and alignment. More recently they have been developing automated machine learning approaches to automatically recognize cell-stroma patterns in large histopathology datasets.

Publications (26)

SPIE Journal Paper | 14 June 2024 Open Access
Jason T. Smith, Chao J. Liu, Jeannine Degnan, Jonathan N. Ouellette, Matthew W. Conklin, Anna V. Kellner, Christina M. Scribano, Laura Hrycyniak, Jonathan D. Oliner, Chris Zahm, Eric Wait, Kevin W. Eliceiri, John Rafter
JBO, Vol. 29, Issue S2, S22709, (June 2024)
KEYWORDS: Cell death, Tumors, Fluorescence lifetime imaging, Tissues, Cancer, Chemotherapy, Fluorescence, Tumor growth modeling, Autofluorescence, Photons

Proceedings Article | 3 October 2023 Presentation + Paper
Proceedings Volume 12654, 1265404 (2023)
KEYWORDS: Hyperspectral imaging, Plasmonics, Brain tissue, Tissues, Quantum plasmonics, Polarization, Infrared spectroscopy, Imaging spectroscopy, Polymethylmethacrylate, Phosphates, Magnetism

SPIE Journal Paper | 21 June 2023 Open Access
JBO, Vol. 28, Issue 06, 066502, (June 2023)
KEYWORDS: Single photon avalanche diodes, Fluorescence lifetime imaging, Imaging systems, Cameras, Autofluorescence, Fluorescence, Laser scanners, Biomedical optics, Microscopes, Fluorescence intensity

Proceedings Article | 15 March 2023 Presentation
Proceedings Volume PC12386, PC1238605 (2023)
KEYWORDS: Sensors, Microscopy, Fluorescence lifetime imaging, Detector arrays, Cameras, Objectives, Luminescence, Switching, Pulsed laser operation, Photons

SPIE Journal Paper | 8 February 2023 Open Access
Bin Li, Michael S. Nelson, Jenu V. Chacko, Nathan Cudworth, Kevin W. Eliceiri
JBO, Vol. 28, Issue 02, 026501, (February 2023)
KEYWORDS: Education and training, Histopathology, Image resolution, Imaging systems, Denoising, Second harmonic generation, Image enhancement, Image quality, Data modeling, Tissues

Showing 5 of 26 publications
Conference Committee Involvement (26)
Multiphoton Microscopy in the Biomedical Sciences XXV
25 January 2025 | San Francisco, California, United States
Multiscale Imaging and Spectroscopy VI
25 January 2025 | San Francisco, California, United States
Multiphoton Microscopy in the Biomedical Sciences XXIV
28 January 2024 | San Francisco, California, United States
Multiscale Imaging and Spectroscopy V
27 January 2024 | San Francisco, California, United States
Multiphoton Microscopy in the Biomedical Sciences XXIII
29 January 2023 | San Francisco, California, United States
Showing 5 of 26 Conference Committees
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