Tissue Engineering methods have become more and more relevant for orthopedic applications, especially for cartilage
repair with autologous chondrocytes. In order to monitor the healing process and bonding between cartilage and the
artificial implant, the boundary zone must be imaged non-invasively, for example with OCT. Optical Coherence
Tomography (OCT) is a short coherent light based measuring technique which allows the generation of cross-section
images of semi-transparent media with a depth resolution of up to 5 μm and a measuring depth of 1-2 mm. Especially for
the imaging of cartilage OCT offers new diagnostic possibilities, as conventional methods such as ultrasound and x-ray
imaging often do not yield satisfactory resolution or contrast. In this paper, an OCT measurement setup for imaging of
human cartilage tissue with OCT is demonstrated, allowing a detection of local damaging and lesions. Furthermore, both
compressed and uncompressed collagen gel pads were implanted into human cartilage samples. OCT measurements are
presented for samples in different stages of growth, focusing on the boundary zones. Comparisons with histologies are
shown, demonstrating the ability of OCT to enable a monitoring of the healing progress in tissue engineering based
therapy.
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