Mr. Kristofer Schroder Profile

Kristofer Schroder

at Rice Univ

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Proceedings Article | 4 March 2019 Presentation

Low-cost diagnostic for monitoring neonatal jaundice in low-resource settings (Conference Presentation)

Pelham Keahey, Mathieu Simeral, Kristofer Schroder, Meaghan Bond, Prince Mtenthaonnga, Queen Dube, Rebecca Richards-Kortum

Proceedings Volume 10885, 108850M (2019) https://doi.org/10.1117/12.2510066

KEYWORDS: Diagnostics, Blood, Phototherapy, Point-of-care devices

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Neonatal Jaundice is a common condition in newborns caused by excess bilirubin accumulating in the blood. Bilirubin is a neurotoxin and if left untreated can cause permanent neurological impairment or death. Jaundice resulting from unconjugated hyperbilirubinemia can be easily treated using blue light phototherapy, and several low-cost treatment systems have been built for low-resource settings. However, there is still a lack of an appropriate low-cost diagnostic. To address this, we present BiliSpec, a low-cost paper lateral flow disposable and reader to measure total bilirubin from whole blood. The system can be used at the point-of-care and measure bilirubin concentration within minutes. The accuracy correlates well with a reference laboratory standard (r = 0.996). We then performed a pilot clinical study using BiliSpec at Queen Elizabeth Central Hospital in Blantyre, Malawi. Bilirubin concentrations measured with BiliSpec correlated well with a laboratory reference standard in a 94 patient study (r = 0.973). Bilirubin concentrations measured ranged from 1.1 mg/dL to 23.0 mg/dL. The mean difference between BiliSpec and the laboratory standard was 0.3 mg/dL (95% CI: −1.7–2.2 mg/dL).

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