Dr. Kristy K. Brock Profile

Dr. Kristy K. Brock

Assistant Professor at Univ of Texas MD Anderson Cancer Ctr

SPIE Involvement:

Conference Program Committee | Author

Proceedings Article | 17 March 2020 Paper

Towards assessment of histopathology correlation with multiple imaging modalities: A pilot study using a visible mouse

Anando Sen, Charles Kingsley, Jorge de la Cerda, F. William Schuler, Abdallah S. Mohamed, Mark Pagel, Kristy Brock

Proc. SPIE. 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging

KEYWORDS: Tissues, Optical coherence tomography, Magnetic resonance imaging, Image segmentation, Image registration, Medical imaging, Computed tomography, In vivo imaging, Positron emission tomography, 3D image processing

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Proceedings Article | 19 March 2018 Paper

Improvement of liver ablation treatment for colorectal liver metastases

Brian Anderson, Ethan Lin, Guillaume Cazoulat, Sanjay Gupta, Bruno Odisio, Kristy Brock

Proc. SPIE. 10576, Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling

KEYWORDS: Oncology, Liver, Cancer, Tumors, Image registration, Colorectal cancer, Computed tomography, Error control coding, Model-based design, Lawrencium

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Proceedings Article | 21 March 2014 Paper

A hybrid biomechanical intensity based deformable image registration of lung 4DCT

Navid Samavati, Michael Velec, Kristy Brock

Proc. SPIE. 9034, Medical Imaging 2014: Image Processing

KEYWORDS: Chest, Tumors, Tissues, Interfaces, Image registration, Lung, Finite element methods, Algorithm development, Motion models, Image-guided intervention

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Proceedings Article | 27 February 2010 Paper

Demons deformable registration for cone-beam CT guidance: registration of pre- and intra-operative images

S. Nithiananthan, K. Brock, M. Daly, H. Chan, J. Irish, J. Siewerdsen

Proc. SPIE. 7625, Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling

KEYWORDS: Neck, X-ray computed tomography, Detection and tracking algorithms, Tissues, Imaging systems, Distortion, Image registration, Head, Computed tomography, Reconstruction algorithms

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Proceedings Article | 24 February 2010 Paper

Biomechanical based image registration for head and neck radiation treatment

Adil Al-Mayah, Joanne Moseley, Shannon Hunter, Mike Velec, Lily Chau, Stephen Breen, Kristy Brock

Proc. SPIE. 7625, Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling

KEYWORDS: Neck, Cancer, Tumors, 3D modeling, Image registration, Radiotherapy, Head, Finite element methods, Computed tomography, Rigid registration

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Proceedings Article | 13 March 2009 Paper

Effect of heterogeneous material of the lung on deformable image registration

Adil Al-Mayah, Joanne Moseley, Mike Velec, Kristy Brock

Proc. SPIE. 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling

KEYWORDS: Chest, Tumors, Mechanics, Tissues, 3D modeling, Image registration, Lung, Finite element methods, Motion models, Lawrencium

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Proceedings Article | 13 March 2009 Paper

High-performance intraoperative cone-beam CT on a mobile C-arm: an integrated system for guidance of head and neck surgery

J. Siewerdsen, M. Daly, H. Chan, S. Nithiananthan, N. Hamming, K. Brock, J. Irish

Proc. SPIE. 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling

KEYWORDS: Endoscopy, Image visualization, Neck, 3D acquisition, Surgery, Imaging systems, Video, Image registration, Head, 3D image processing

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Proceedings Article | 21 March 2007 Paper

Multimode C-arm fluoroscopy, tomosynthesis, and cone-beam CT for image-guided interventions: from proof of principle to patient protocols

J. Siewerdsen, M. Daly, G. Bachar, D. Moseley, G. Bootsma, K. Brock, S. Ansell, G. Wilson, S. Chhabra, D. Jaffray, J. Irish

Proc. SPIE. 6510, Medical Imaging 2007: Physics of Medical Imaging

KEYWORDS: X-ray computed tomography, Visualization, Surgery, Imaging systems, Sensors, Stereoscopy, Head, Image quality, Computed tomography, Image-guided intervention

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Proceedings Article | 13 March 2006 Paper

A multi-organ biomechanical model to analyze prostate deformation due to large deformation of the rectum

Kristy Brock, Cynthia Ménard, Jennifer Hensel, David Jaffray

Proc. SPIE. 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images

KEYWORDS: Gold, Magnetic resonance imaging, Image registration, Radiotherapy, Finite element methods, Prostate, Computed tomography, Bladder, Natural surfaces, Rectum

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Proceedings Article | 14 April 2005 Paper

Nanoengineered multimodal contrast agent for medical image guidance

Gregory Perkins, Jinzi Zheng, Kristy Brock, Christine Allen, David Jaffray

Proc. SPIE. 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images

KEYWORDS: Liver, Blood, Magnetic resonance imaging, Image registration, Medical imaging, Iodine, Kidney, Computed tomography, In vivo imaging, Gadolinium

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Multimodality imaging has gained momentum in radiation therapy planning and image-guided treatment delivery. Specifically, computed tomography (CT) and magnetic resonance (MR) imaging are two complementary imaging modalities often utilized in radiation therapy for visualization of anatomical structures for tumour delineation and accurate registration of image data sets for volumetric dose calculation. The development of a multimodal contrast agent for CT and MR with prolonged in vivo residence time would provide long-lasting spatial and temporal correspondence of the anatomical features of interest, and therefore facilitate multimodal image registration, treatment planning and delivery. The multimodal contrast agent investigated consists of nano-sized stealth liposomes encapsulating conventional iodine and gadolinium-based contrast agents. The average loading achieved was 33.5 ± 7.1 mg/mL of iodine for iohexol and 9.8 ± 2.0 mg/mL of gadolinium for gadoteridol. The average liposome diameter was 46.2 ± 13.5 nm. The system was found to be stable in physiological buffer over a 15-day period, releasing 11.9 ± 1.1% and 11.2 ± 0.9% of the total amounts of iohexol and gadoteridol loaded, respectively. 200 minutes following in vivo administration, the contrast agent maintained a relative contrast enhancement of 81.4 ± 13.05 differential Hounsfield units (ΔHU) in CT (40% decrease from the peak signal value achieved 3 minutes post-injection) and 731.9 ± 144.2 differential signal intensity (ΔSI) in MR (46% decrease from the peak signal value achieved 3 minutes post-injection) in the blood (aorta), a relative contrast enhancement of 38.0 ± 5.1 ΔHU (42% decrease from the peak signal value achieved 3 minutes post-injection) and 178.6 ± 41.4 ΔSI (62% decrease from the peak signal value achieved 3 minutes post-injection) in the liver (parenchyma), a relative contrast enhancement of 9.1 ± 1.7 ΔHU (94% decrease from the peak signal value achieved 3 minutes post-injection) and 461.7 ± 78.1 ΔSI (60% decrease from the peak signal value achieved 5 minutes post-injection) in the kidney (cortex) of a New Zealand white rabbit. This multimodal contrast agent, with prolonged in vivo residence time and imaging efficacy, has the potential to bring about improvements in the fields of medical imaging and radiation therapy, particularly for image registration and guidance.

Showing 5 of 10 publications

Conference Committee Involvement (1)

Image-Guided Procedures, Robotic Interventions, and Modeling

15 February 2021 | Online Only, California, United States

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