Dr. Laura A. Sordillo Profile

Dr. Laura A. Sordillo

SPIE Involvement:

Editor | Author

Area of Expertise:

Brain Diseases , Cancer Research , Biomedical Optics , NIR Imaging , Bone Diseases , Novel Optical Techniques

Profile Summary

Corning Office of STEM Graduate Research Fellowship Award 2018-2019
Corning Office of STEM Graduate Research Fellowship Award 2017-2018
GSOE at CCNY Fellowship 2016-2017
CCNY- MSKCC Partnership Graduate Program 2011-2012
Kaylie Prize for Entrepreneurship 2011

Publications (36)

SPIE Press Book | 1 March 2022

Short-Wavelength Infrared Windows for Biomedical Applications

KEYWORDS: Short wave infrared radiation, Tissues, Absorption, Luminescence, Biomedical optics, Hyperspectral imaging, Optical coherence tomography, Imaging systems, Near infrared, Scattering

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Short-Wavelength Infrared Windows for Biomedical Applications

Proceedings Article | 9 March 2020 Presentation

Presentation

Exploring diagnosing brain disease with quantum entanglement (Conference Presentation)

Enrique Galvez, Faith Williams, Baibhav Sharma, Aayam Bista, Behzad Khajavi, Jhonny Castrillon, Lingyan Shi, Sandra Mamani, Lin Zhang, Laura Sordillo, Robert Alfano

Proceedings Volume 11234, 112340J (2020) https://doi.org/10.1117/12.2545447

KEYWORDS: Brain diseases, Tissues, Photons, Brain, Tissue optics, Alzheimer's disease, Diagnostics, Tomography, Neuroimaging

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Proceedings Article | 21 February 2020 Paper

Paper

Abnormal tryptophan metabolism in Alzheimer’s disease (ALZ): label-free spectroscopy suggests an alternative theory of ALZ causation

Laura Sordillo, Peter Sordillo, Robert Alfano

Proceedings Volume 11234, 112341P (2020) https://doi.org/10.1117/12.2550309

KEYWORDS: Brain, Spectroscopy, Alzheimer's disease, Proteins, Cancer, Absorption, Fluorescence spectroscopy, Brain diseases, Neurodegeneration

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Proceedings Article | 21 February 2020 Paper

Paper

SWIR windows as an adjunctive to biopsy for distinguishing and monitoring benign and malignant tissues

Laura Sordillo, Diana Sordillo, Lingyan Shi, Peter Sordillo, Robert Alfano

Proceedings Volume 11234, 112341H (2020) https://doi.org/10.1117/12.2550311

KEYWORDS: Short wave infrared radiation, Tissues, Photonics, Biopsy, Imaging spectroscopy, Tissue optics, Windows, Light scattering, Prostate, Cancer, Brain imaging, Biomedical optics and medical imaging

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Proceedings Article | 4 March 2019 Paper

Paper

Advances in medical applications using SWIR light in the wavelength range from 1000 to 2500 nm

Laura Sordillo, Lingyan Shi, Diana Sordillo, Peter Sordillo, Robert Alfano

Proceedings Volume 10873, 108730T (2019) https://doi.org/10.1117/12.2513382

KEYWORDS: Short wave infrared radiation, Near infrared, Imaging spectroscopy, Bone, Windows, Tissues, Brain, Tissue optics, Absorption, Scattering

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Proceedings Article | 4 March 2019 Paper

Paper

Alzheimer’s disease: label-free fluorescence shows increases in indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO) activity in affected areas of the brain

Laura Sordillo, Lin Zhang, Peter Sordillo, Robert Alfano

Proceedings Volume 10873, 108731C (2019) https://doi.org/10.1117/12.2513384

KEYWORDS: Parkinson's disease, Fluorescence spectroscopy, Alzheimer's disease, Brain, Tissues, Luminescence, Optical properties, Oncology, Cancer

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Proceedings Article | 1 March 2019 Paper

Paper

Twisted light transfers OAM and SAM to electrons in a GaAs photocathode

Laura Sordillo, Sandra Mamani, Mikhail Sharonov, Robert Alfano

Proceedings Volume 10935, 109351P (2019) https://doi.org/10.1117/12.2514646

KEYWORDS: Electrons, Gallium arsenide, Polarization, Photonic devices, Photons, Cesium, Sapphire lasers, Optical amplifiers, Semiconductors, Spintronics

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Proceedings Article | 24 April 2018 Paper

Paper

Resonance Raman and fluorescence spectroscopy to evaluate increased brain kynurenine pathway activity in samples from patients with neurodegenerative disease

Laura Sordillo, Lin Zhang, Lingyan Shi, Vidyasagar Sriramoju, Peter Sordillo, Robert Alfano

Proceedings Volume 10711, 107111F (2018) https://doi.org/10.1117/12.2317118

KEYWORDS: Alzheimer's disease, Brain, Raman spectroscopy, Tissues, Luminescence, Fluorescence spectroscopy, Control systems, Spectroscopy, Resonance enhancement, Neurodegeneration

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Proceedings Article | 21 February 2018 Paper

Paper

Alzheimer's disease evaluation using label-free, stainless, fluorescence to measure tryptophan metabolism along the kynurenine pathway

Laura Sordillo, Lin Zhang, Lingyan Shi, Vidyasagar Sriramoju, Peter Sordillo, Robert Alfano

Proceedings Volume 10489, 104891E (2018) https://doi.org/10.1117/12.2298391

KEYWORDS: Alzheimer's disease, Brain, Tissues, Luminescence, Tissue optics, Fluorescence spectroscopy, Tumors, Spectroscopy, Breast cancer, Cancer

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Proceedings Article | 19 February 2018 Paper

Paper

Statistical analysis and machine learning algorithms for optical biopsy

Binlin Wu, Cheng-hui Liu, Susie Boydston-White, Hugh Beckman, Vidyasagar Sriramoju, Laura Sordillo, Chunyuan Zhang, Lin Zhang, Lingyan Shi, Jason Smith, Jacob Bailin, Robert Alfano

Proceedings Volume 10489, 104890T (2018) https://doi.org/10.1117/12.2288089

KEYWORDS: Tissues, Raman spectroscopy, Machine learning, Biopsy, Principal component analysis, Neurons, Statistical analysis, Diagnostics, Skin, Cancer

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SPIE Journal Paper | 3 April 2017 Open Access

Open Access

Short wavelength infrared optical windows for evaluation of benign and malignant tissues

Diana Sordillo, Laura Sordillo, Peter Sordillo, Lingyan Shi, Robert Alfano

JBO, Vol. 22, Issue 04, 045002, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.045002

KEYWORDS: Tissues, Short wave infrared radiation, Near infrared, Absorption, Signal attenuation, Collagen, Bone, Infrared radiation, Scattering

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Proceedings Article | 17 February 2017 Paper

Paper

Resonance Raman of BCC and normal skin

Cheng-hui Liu, Vidyasagar Sriramoju, Susie Boydston-White, Binlin Wu, Chunyuan Zhang, Zhe Pei, Laura Sordillo, Hugh Beckman, Robert Alfano

Proceedings Volume 10060, 100601B (2017) https://doi.org/10.1117/12.2254628

KEYWORDS: Proteins, Cancer, Skin cancer, Biopsy, Statistical analysis

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SPIE Journal Paper | 21 December 2016 Open Access

Open Access

Vulnerable atherosclerotic plaque detection by resonance Raman spectroscopy

Cheng-hui Liu, Susie Boydston-White, Arel Weisberg, Wubao Wang, Laura Sordillo, Adler Perotte, Vincent Tomaselli, Peter Sordillo, Zhe Pei, Lingyan Shi, Robert Alfano

JBO, Vol. 21, Issue 12, 127006, (December 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.12.127006

KEYWORDS: Raman spectroscopy, Tissues, Proteins, Virtual point source, Confocal microscopy, Photography, Collagen, Arteries, Absorption, Molecules

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Proceedings Article | 17 March 2016 Paper

Paper

Imaging using a supercontinuum laser to assess tumors in patients with breast carcinoma

Laura Sordillo, Peter Sordillo, R. Alfano

Proceedings Volume 9703, 97031Z (2016) https://doi.org/10.1117/12.2240512

KEYWORDS: Breast, Light sources, Near infrared, Tissues, Tumors, Tissue optics, Infrared sensors, Sensors, Cameras

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Proceedings Article | 15 March 2016 Paper

Paper

Fourth near-infrared optical window for assessment of bone and other tissues

Diana Sordillo, Laura Sordillo, Peter Sordillo, Robert Alfano

Proceedings Volume 9689, 96894J (2016) https://doi.org/10.1117/12.2214320

KEYWORDS: Near infrared, Windows, Bone, Absorption, Scattering, Tissue optics, Optical properties, Tissues, Collagen, Deep tissue imaging, Signal attenuation, Breast, Prostate

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Proceedings Article | 11 March 2016 Paper

Paper

Label-free pathological evaluation of grade 3 cancer using Stokes shift spectroscopy

Laura Sordillo, Peter Sordillo, R. Alfano

Proceedings Volume 9703, 97030W (2016) https://doi.org/10.1117/12.2214327

KEYWORDS: Cancer, Spectroscopy, Tissue optics, Luminescence, Breast cancer, Tissues, Optical spectroscopy, Pathology, Fluorescence spectroscopy, Optical properties, Tumors, Breast, Collagen, Absorption, Statistical analysis

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Proceedings Article | 11 March 2016 Paper

Paper

Imaging using a supercontinuum laser to assess tumors in patients with breast carcinoma

Laura Sordillo, Peter Sordillo, R. Alfano

Proceedings Volume 9703, 97031L (2016) https://doi.org/10.1117/12.2214330

KEYWORDS: Breast, Tissue optics, Windows, CCD image sensors, Sensors, Near infrared, CCD cameras, Indium gallium arsenide, Cameras, Infrared sensors, Light sources, Tissues, Tumors

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Proceedings Article | 7 March 2016 Paper

Paper

Optical pathology study of human abdominal aorta tissues using confocal micro resonance Raman spectroscopy

Cheng-hui Liu, Susie Boydston-White, Wubao Wang, Laura Sordillo, Lingyan Shi, Arel Weisberg, Vincent Tomaselli, Peter Sordillo, Robert Alfano

Proceedings Volume 9703, 97031S (2016) https://doi.org/10.1117/12.2213368

KEYWORDS: Tissues, Raman spectroscopy, Spectroscopy, Tissue optics, Confocal microscopy, Soft tissue optics, Pathology, In vitro testing, Cerebrovascular diseases, Molecular photonics

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Proceedings Article | 12 March 2015 Paper

Paper

Imaging of tissue using a NIR supercontinuum laser light source with wavelengths in the second and third NIR optical windows

Laura Sordillo, Lukas Lindwasser, Yury Budansky, Philippe Leproux, R. Alfano

Proceedings Volume 9319, 93191Y (2015) https://doi.org/10.1117/12.2078435

KEYWORDS: Near infrared, Laser tissue interaction, Light sources, Sensors, Tissue optics, Indium gallium arsenide, Light scattering, Scattering, Absorption

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Proceedings Article | 11 March 2015 Paper

Paper

Nonnegative constraint analysis of key fluorophores within human breast cancer using native fluorescence spectroscopy excited by selective wavelength of 300 nm

Yang Pu, Laura Sordillo, Robert Alfano

Proceedings Volume 9318, 93180V (2015) https://doi.org/10.1117/12.2076102

KEYWORDS: Tissues, Luminescence, Breast, Cancer, Breast cancer, Fluorescence spectroscopy, Collagen, Tissue optics, Ultraviolet radiation, Tumors

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Proceedings Article | 11 March 2015 Paper

Paper

High histologic grade and increased relative content of tryptophan in breast cancer using ratios from fingerprint fluorescence spectral peaks

Laura Sordillo, Peter Sordillo, Yury Budansky, Yang Pu, R. Alfano

Proceedings Volume 9318, 931804 (2015) https://doi.org/10.1117/12.2078414

KEYWORDS: Tumors, Breast cancer, Breast, Tissues, Lymphatic system, Receptors, Cancer, Luminescence, Collagen, Spectroscopy

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Proceedings Article | 11 March 2015 Paper

Paper

A comparison study of different excitation wavelengths to determine the relative content of key biomolecules in breast cancer and breast normal tissue

Laura Sordillo, Peter Sordillo, Yury Budansky, Yang Pu, R. Alfano

Proceedings Volume 9318, 93180Y (2015) https://doi.org/10.1117/12.2078432

KEYWORDS: Breast, Tissues, Breast cancer, Tumors, Luminescence, Tissue optics, Spectroscopy, Cancer, Receptors, Laser tissue interaction

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Proceedings Article | 9 March 2015 Paper

Paper

Imaging microfractures and other abnormalities of bone using a supercontinuum laser source with wavelengths in the four NIR optical windows

Laura Sordillo, Peter Sordillo, Yury Budansky, Philippe Leproux, R. Alfano

Proceedings Volume 9303, 93033Y (2015) https://doi.org/10.1117/12.2181312

KEYWORDS: Bone, Near infrared, Tissue optics, Light sources, Laser sources, Sensors, Tissues, Cameras, Laser tissue interaction

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SPIE Journal Paper | 6 March 2015 Open Access

Open Access

Near-infrared supercontinuum laser beam source in the second and third near-infrared optical windows used to image more deeply through thick tissue as compared with images from a lamp source

Laura Sordillo, Lukas Lindwasser, Yury Budansky, Philippe Leproux, Robert Alfano

JBO, Vol. 20, Issue 03, 030501, (March 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.3.030501

KEYWORDS: Near infrared, Tissue optics, Laser tissue interaction, Lamps, Sensors, Light sources, Light scattering, Signal attenuation, Scattering

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Proceedings Article | 26 February 2015 Paper

Paper

Novel, near-infrared spectroscopic, label-free, techniques to assess bone abnormalities such as Paget's disease, osteoporosis and bone fractures

Diana Sordillo, Laura Sordillo, Lingyan Shi, Yury Budansky, Peter Sordillo, Robert Alfano

Proceedings Volume 9303, 93033Z (2015) https://doi.org/10.1117/12.2181314

KEYWORDS: Bone, Near infrared, Tissue optics, Near infrared spectroscopy, Absorption, Spectroscopy, Collagen, Two photon excitation microscopy, Sensors

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SPIE Journal Paper | 18 December 2014 Open Access

Open Access

Differences in fluorescence profiles from breast cancer tissues due to changes in relative tryptophan content via energy transfer: tryptophan content correlates with histologic grade and tumor size but not with lymph node metastases

Laura Sordillo, Peter Sordillo, Yury Budansky, Yang Pu, Robert Alfano

JBO, Vol. 19, Issue 12, 125002, (December 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.12.125002

KEYWORDS: Tumors, Tissues, Breast cancer, Luminescence, Lymphatic system, Cancer, Breast, Energy transfer, Collagen, Receptors

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Proceedings Article | 8 May 2014 Paper

Paper

Spectral analysis of tissues from patients with cancer using a portable spectroscopic diagnostic ratiometer unit

Laura Sordillo, Yang Pu, Peter Sordillo, Yury Budansky, R. Alfano

Proceedings Volume 9129, 91292R (2014) https://doi.org/10.1117/12.2051847

KEYWORDS: Tissues, Breast, Lung, Cancer, Fluorescence spectroscopy, Tumors, Light emitting diodes, Spectroscopy, Spectroscopes, Neodymium

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Proceedings Article | 8 May 2014 Paper

Paper

Second and third NIR optical windows for imaging of bone microfractures

Laura Sordillo, Yang Pu, Peter Sordillo, Yury Budansky, R. Alfano

Proceedings Volume 9129, 912912 (2014) https://doi.org/10.1117/12.2051917

KEYWORDS: Bone, Near infrared, Tissue optics, Signal attenuation, Absorption, Tissues, Scattering, Skin, Optical imaging

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SPIE Journal Paper | 7 May 2014 Open Access

Open Access

Deep optical imaging of tissue using the second and third near-infrared spectral windows

Laura Sordillo, Yang Pu, Sebastião Pratavieira, Yury Budansky, Robert Alfano

JBO, Vol. 19, Issue 05, 056004, (May 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.5.056004

KEYWORDS: Tissue optics, Near infrared, Signal attenuation, Tissues, Breast, Absorption, Prostate, Scattering, Optical imaging

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Proceedings Article | 17 March 2014 Paper

Paper

Third therapeutic spectral window for deep tissue imaging

Laura Sordillo, Sebastião Pratavieira, Yang Pu, Kaliris Salas-Ramirez, Lingyan Shi, Lin Zhang, Yury Budansky, R. Alfano

Proceedings Volume 8940, 89400V (2014) https://doi.org/10.1117/12.2040604

KEYWORDS: Tissue optics, Tissues, Signal attenuation, Near infrared, Absorption, Prostate, Breast, Scattering, Photons

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Proceedings Article | 4 March 2014 Paper

Paper

Spatial frequencies from human periosteum at different depths using two-photon microscopic images

Laura Sordillo, Lingyan Shi, Stephen Bhagroo, Theinan Nguyen, Stephanie Lubicz, Yang Pu, Yuri Budansky, Noella Hatak, R. Alfano

Proceedings Volume 8926, 892642 (2014) https://doi.org/10.1117/12.2045476

KEYWORDS: Spatial frequencies, Bone, Collagen, Luminescence, Fourier transforms, Absorption, Microscopy, Two photon excitation microscopy, Fluorescence spectroscopy, Femtosecond phenomena

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Proceedings Article | 4 March 2014 Paper

Paper

Deep tissue imaging of microfracture and non-displaced fracture of bone using the second and third near-infrared therapeutic windows

Laura Sordillo, Yang Pu, P. Sordillo, Yury Budansky, Robert Alfano

Proceedings Volume 8926, 89263V (2014) https://doi.org/10.1117/12.2046706

KEYWORDS: Tissue optics, Bone, Near infrared, Scattering, Tissues, Light scattering, Absorption, Photons, Signal attenuation

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Proceedings Article | 19 March 2013 Paper

Paper

Time-resolved fluorescence for breast cancer detection using an octreotate-indocyanine green derivative dye conjugate

Laura Sordillo, B. Das, Yang Pu, Kexian Liang, Giovanni Milione, Peter Sordillo, Sam Achilefu, R. Alfano

Proceedings Volume 8577, 857708 (2013) https://doi.org/10.1117/12.2003102

KEYWORDS: Tissues, Luminescence, Breast, Breast cancer, Time resolved spectroscopy, Absorption, Receptors, Indocyanine green, Picosecond phenomena, Tumors

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Proceedings Article | 8 March 2013 Paper

Paper

A novel approach to Paget's disease diagnosis and monitoring using near-infrared absorption spectroscopy

Diana Sordillo, Yury Budansky, Peter Sordillo, Laura Sordillo, Robert Alfano

Proceedings Volume 8565, 856566 (2013) https://doi.org/10.1117/12.981747

KEYWORDS: Bone, Near infrared, Tissue optics, Scattering, Absorption spectroscopy, Diffusion, 3D image processing, Computed tomography, Inverse optics, Absorption

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Proceedings Article | 8 March 2013 Paper

Paper

Optical spectroscopy methods to probe key spectral fingerprints of animal bone

Diana Sordillo, Laura Sordillo, Peter Sordillo, Robert Alfano

Proceedings Volume 8565, 856568 (2013) https://doi.org/10.1117/12.2005647

KEYWORDS: Bone, Luminescence, Raman spectroscopy, Collagen, Spectroscopy, Optical spectroscopy, Fluorescence spectroscopy, Blood, Tissues, Calcium

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Proceedings Article | 17 February 2012 Paper

Paper

Compact Stokes shift and fluorescence spectroscopic diagnostics LED ratiometer unit with no moving parts for cancer detection

Laura Sordillo, Yang Pu, Yury Budansky, R. Alfano

Proceedings Volume 8220, 82200I (2012) https://doi.org/10.1117/12.906487

KEYWORDS: Tissues, Breast, Luminescence, Cancer, Light emitting diodes, Spectroscopy, Tissue optics, Fluorescence spectroscopy, Absorption, Optical fibers

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Showing 5 of 36 publications

Conference Committee Involvement (3)

Optical Biopsy

1 February 2017 |

Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis

15 February 2016 |

Optical Biopsy XIII

1 February 2015 |

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