Dr. Lawrence Kulinsky Profile

Dr. Lawrence Kulinsky

SPIE Involvement:

Author

Publications (7)

Proceedings Article | 8 March 2014 Paper

Dielectrophoresis-assisted electroconductive polymer-based fabrication of high surface area electrodes

Victor Perez-Gonzalez, Vinh Ho, Lawrence Kulinsky, Sergio Martinez-Chapa

Proceedings Volume 9056, 905628 (2014) https://doi.org/10.1117/12.2046420

KEYWORDS: Electrodes, Particles, Dielectrophoresis, Gold, Semiconducting wafers, Microfabrication, Polymerization, Polymers, Photoresist materials, Curium

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Proceedings Article | 9 April 2010 Paper

Utilization of electroactive polymer actuators in micromixing and in extended-life biosensor applications

Vinh Ho, Mark Shimada, David Szeto, Xavier Casadevall i Solvas, Daniel Scott, Luisa Stella Dolci, Lawrence Kulinsky, Sylvia Daunert, Marc Madou

Proceedings Volume 7642, 764235 (2010) https://doi.org/10.1117/12.848877

KEYWORDS: Biosensors, Gold, Glucose, Electrodes, Actuators, Microactuators, Semiconducting wafers, Photoresist materials, Electroactive polymers, Ions

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Proceedings Article | 1 April 2010 Paper

Novel fabrication technology for three-dimensional high surface area pyrolized structures

Vinh Ho, Mark Shimada, David Szeto, Partha Mukherjee, Qinjun Kang, Lawrence Kulinsky, Marc Madou

Proceedings Volume 7647, 76472F (2010) https://doi.org/10.1117/12.848878

KEYWORDS: Electrodes, Photoresist materials, Fractal analysis, Carbon, Sensors, Resistance, Electroactive polymers, Manufacturing, Biosensors, Polymers

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Proceedings Article | 5 April 2006 Paper

System-based approach for an advanced drug delivery platform

Lawrence Kulinsky, Han Xu, Han-Kuan Tsai, Marc Madou

Proceedings Volume 6173, 61730M (2006) https://doi.org/10.1117/12.658890

KEYWORDS: Biosensors, Glucose, Gold, Manufacturing, Sensors, Chromium, Actuators, Polymers, Silicon, Electrodes

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Present study is looking at the problem of integrating drug delivery microcapsule, a bio-sensor, and a control mechanism into a biomedical drug delivery system. A wide range of medical practices from cancer therapy to gastroenterological treatments can benefit from such novel bio-system. Drug release in our drug delivery system is achieved by electrochemically actuating an array of polymeric valves on a set of drug reservoirs. The valves are bi-layer structures, made in the shape of a flap hinged on one side to a valve seat, and consisting of thin films of evaporated gold and electrochemically deposited polypyrrole (PPy). These thin PPy(DBS) bi-layer flaps cover access holes of underlying chambers micromachined in a silicon substrate. Chromium and polyimide layers are applied to implement "differential adhesion" to obtain a voltage induced deflection of the bilayer away from the drug reservoir. The Cr is an adhesion-promoting layer, which is used to strongly bind the gold layer down to the substrate, whereas the gold adheres weakly to polyimide. Drug actives (dry or wet) were pre-stored in the chambers and their release is achieved upon the application of a small bias (~ 1V). Negative voltage causes cation adsorption and volume change in PPy film. This translates into the bending of the PPy/Au bi-layer actuator and release of the drug from reservoirs. This design of the drug delivery module is miniaturized to the dimensions of 200μm valve diameter. Galvanostatic and potentiostatic PPy deposition methods were compared, and potentiostatic deposition method yields film of more uniform thickness. PPy deposition experiments with various pyrrole and NaDBS concentrations were also performed. Glucose biosensor based on glucose oxidase (GOx) embedded in the PPy matrix during elechtrochemical deposition was manufactured and successfully tested. Multiple-drug pulsatile release and continuous linear release patterns can be implemented by controlling the operation of an array of valves. Varying amounts of drugs, together with more complex controlling strategies would allow creation of more complex drug delivery patterns.