New fluorescence based optical fiber sensors have been developed for the monitoring of pH, Carbon Dioxide, and Oxygen in radial arteries. These sensors utilize wavelength multiplexing for detection of three parameters with one optical fiber. Unlike sensing systems in which separate fibers are used for each parameter, wavelength multiplexed systems have the potential for parameter to parameter optical interference. We refer to this interference as 'crosstalk'. Wavelength multiplexed systems and their potential for crosstalk are described. Investigating methods for obtaining independent isolation of multiple parameters under laboratory conditions are discussed. Computational methods of quantifying crosstalk are shown. Specific test protocols are provided, along with representative test results. Minimal crosstalk was found in the systems tested.
New fluorescence-based disposable probes have been developed for monitoring of pH, carbon dioxide, and oxygen in extracorporeal loops and radial arteries. These low cost, small diameter sensors fit through most standard female Luer Lock fittings. The portable monitor and its interface to the probes are described. In-vitro performance of the sensor systems versus tonometered bovine blood and blood analyzer calibration ampules are shown, along with a brief discussion of clinical applications of these devices.