Advances in nanotechnology applications in medicine, including enhanced cancer therapy cause necessity investigation of nanoparticles toxicity. Herein, we report results encompassing the histological examination of tissues and biochemical tests of blood plasma after intravenous injection of gold nanoparticles. Besides of this, we analyzed passive accumulation of nanoshells in the tumor.
We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom and laboratory rats. Temperature distributions on the animal skin surface at hypodermic and intramuscular injection of gold nanoparticle suspensions and affectations by the laser radiation are measured in vivo with a thermal imaging system. The results of temperature measurements are compared with tissue histology.
This paper deals with the problem of using semiconductor laser radiation (wavelength 810 nm) for healing skin and
mucous cancer of small animal. Opportunities of using different types of lasers for clinical applications under
oncological diseases of skin and oral mucous have been analyzed. We determined power densities and duration of laser
irradiation for different types of tumors. IR thermograph was used for noninvasive temperature monitoring in the area of
tumor localization. For noninvasive measuring and registration of spatial distribution of radiation temperature of
investigated objects, we used IR Imager IRISYS 4010 Infrared Integrated System Ltd (UK).