Dr. Linda Z. Shi Profile

Dr. Linda Z. Shi

Project Scientist at Univ of California San Diego

SPIE Involvement:

Author

Publications (22)

Proceedings Article | 5 October 2023 Poster + Paper

Effects of H2O2 and high doses of nicotinamide on laser-induced neuronal degeneration in mouse model of Huntington’s disease

Sophia Barber, Sarah Chen, Veronica Gomez, Chengbiao Wu, Linda Shi

Proceedings Volume 12649, 126490V (2023) https://doi.org/10.1117/12.2677626

KEYWORDS: Axons, Neurons, Shrinkage, Neurological disorders, Nervous system, Laser cutting, Resistance, Brain diseases, Laser induced damage, Control systems

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Proceedings Article | 5 October 2023 Poster + Paper

Tracking of C. Reinhardtii flagellar disassembly following femtosecond laser ablation

Katelyn Lee, Hiro Ishikawa, Celina Jiang, Bethany Campbell, Elise Stuman, Jiayu Hu, Veronica Gomez, Wallace Marshall, Linda Shi

Proceedings Volume 12649, 126490T (2023) https://doi.org/10.1117/12.2677805

KEYWORDS: Laser ablation, Proteins, Femtosecond phenomena, Shrinkage, Organisms, Diseases and disorders, Polarizers

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Proceedings Article | 5 October 2023 Poster + Paper

Effects of laser induced shockwave on neurons from an Alzheimer’s mouse model

Veronica Gomez Godinez, Steven Zheng, Matthew Hsin-De Tran, Chengbiao Wu, Linda Shi

Proceedings Volume 12649, 126490U (2023) https://doi.org/10.1117/12.2677546

KEYWORDS: Calcium, Neurons, Lithium, Mouse models, Animal model studies, Alzheimer's disease, Injuries, Traumatic brain injury, In vitro testing, Alzheimer disease

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Proceedings Article | 3 October 2022 Poster + Paper

Laser-induced photolysis leads to a Ca2+ transient in surrounding astrocytes which is dependent on internal stores

Veronica Gomez Godinez, Huayan Li, Yixuan Kuang, Linda Shi, Michael Berns

Proceedings Volume 12198, 121980E (2022) https://doi.org/10.1117/12.2632869

KEYWORDS: Calcium, Photolysis, Cell death, Injuries, Brain, Traumatic brain injury

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Proceedings Article | 3 August 2021 Paper

Laser induced shockwave paired with FRET to study neuronal responses to shear stress

Veronica Gomez Godinez, Vikash Morar, Christopher Carmona, Yingli Gu, Kijung Sung, Linda Shi, Chengbiao Wu, Daryl Preece, Michael Berns

Proceedings Volume 11798, 117982H (2021) https://doi.org/10.1117/12.2595803

KEYWORDS: Calcium, Fluorescence resonance energy transfer, Neurons, Biosensors, Traumatic brain injury

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Proceedings Article | 17 September 2018 Presentation

Characterizing forces imparted on cells using laser-induced shockwaves (Conference Presentation)

Christopher Carmona, Michael Berns, Daryl Preece, Veronica Gomez-Godinez, Linda Shi

Proceedings Volume 10723, 107230D (2018) https://doi.org/10.1117/12.2322797

KEYWORDS: Traumatic brain injury, Imaging systems, Brain, Neurodegeneration, Injuries, Optical tweezers, Laser ablation, Electro optical modeling, Pathogens, Neurons

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Proceedings Article | 25 August 2017 Paper

Probing mechanobiology with laser-induced shockwaves

Christopher Carmona, Daryl Preece, Veronica Gomez-Godinez, Linda Shi, Michael Berns

Proceedings Volume 10347, 103470D (2017) https://doi.org/10.1117/12.2274563

KEYWORDS: Traumatic brain injury, Cavitation, Dye lasers, Plasma, In vitro testing, Pulsed laser operation, Neurodegeneration, Visualization, Imaging systems, Animal model studies

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Proceedings Article | 5 October 2015 Presentation

Reactive oxygen species production in single cells following laser irradiation (Presentation Recording)

Michelle Duquette, Justine Kim, Linda Shi, Michael Berns

Proceedings Volume 9548, 95480S (2015) https://doi.org/10.1117/12.2190375

KEYWORDS: Oxygen, Laser irradiation, Laser induced damage, Proteins, Video, Optical tweezers, Optical micromanipulation, Current controlled current source

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Proceedings Article | 25 August 2015 Presentation + Paper

A model for traumatic brain injury using laser induced shockwaves

A. Selfridge, D. Preece, V. Gomez, L. Shi, M. Berns

Proceedings Volume 9548, 95480P (2015) https://doi.org/10.1117/12.2189724

KEYWORDS: Traumatic brain injury, Neurons, Wavelets, Axons, Luminescence, Lithium, Systems modeling, Laser induced damage, In vitro testing, Microfluidics

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SPIE Journal Paper | 13 February 2015 Open Access

Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy

Aaron Selfridge, Nicholas Hyun, Chai-Chun Chiang, Sol Reyna, April Weissmiller, Linda Shi, Daryl Preece, William Mobley, Michael Berns

NPh, Vol. 2, Issue 01, 015006, (February 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.1.015006

KEYWORDS: Neurons, Axons, Laser induced damage, Stem cells, Injuries, Cones, Nerve, Neurophotonics, Microfluidics, Microscopes

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Proceedings Article | 4 March 2014 Paper

Effects of media viscosity and particle size on optical trapping of microspheres

Nima Khatibzadeh, Yesenia Rocha, Linda Shi, Michael Berns

Proceedings Volume 8947, 89470G (2014) https://doi.org/10.1117/12.2040014

KEYWORDS: Optical tweezers, Objectives, Microscopes, Microfluidics, Particles, Optical spheres, Refractive index, Continuous wave operation, Ytterbium, Fiber lasers

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SPIE Journal Paper | 22 March 2013 Open Access

Purple sea urchin Strongylocentrotus purpuratus gamete manipulation using optical trapping and microfluidics

Charlie Chandsawangbhuwana, Linda Shi, Qingyuan Zhu, Michael Berns

JBO, Vol. 18, Issue 04, 040501, (March 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.4.040501

KEYWORDS: Microfluidics, Optical tweezers, In vitro testing, Lanthanum, Microscopes, Silicon, Optical manipulation, Physiology, Radiation effects, Ocean optics

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SPIE Journal Paper | 6 March 2012 Open Access

Effects of viscosity on sperm motility studied with optical tweezers

Nicholas Hyun, Charlie Chandsawangbhuwana, Collin Yang-Wong, Michael Berns, Qingyuan Zhu, Linda Shi

JBO, Vol. 17, Issue 02, 025005, (March 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.2.025005

KEYWORDS: Optical tweezers, Luminescence, Data modeling, Refractive index, Computing systems, MATLAB, Acquisition tracking and pointing, Optical tracking, Statistical analysis, Lanthanum

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SPIE Journal Paper | 7 February 2012 Open Access

High-throughput optofluidic system for the laser microsurgery of oocytes

Charlie Chandsawangbhuwana, Linda Shi, Qingyuan Zhu, Michael Berns, Mark Alliegro

JBO, Vol. 17, Issue 1, 015001, (February 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.1.015001

KEYWORDS: Microfluidics, Laser systems engineering, Laser ablation, Semiconducting wafers, Control systems, Laser microsurgery, Glasses, Ocean optics, Microscopy, Objectives

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Proceedings Article | 20 August 2009 Paper

A combined double-tweezers and wavelength-tunable laser nanosurgery microscope

Qingyuan Zhu, Shahab Parsa, Linda Shi, Marcellinus Harsono, Nicole Wakida, Michael Berns

Proceedings Volume 7400, 74000B (2009) https://doi.org/10.1117/12.825813

KEYWORDS: Optical tweezers, Microscopes, Laser ablation, Ultraviolet radiation, Laser optics, Beam splitters, Laser microsurgery, Laser therapeutics, Pulsed laser operation, Laser vision correction

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SPIE Journal Paper | 1 January 2008 Open Access

Use of laser tweezers to analyze sperm motility and mitochondrial membrane potential

Jaclyn Nascimento, Linda Shi, Charlie Chandsawangbhuwana, James Tam, Barbara Durrant, Elliot Botvinick, Michael Berns

JBO, Vol. 13, Issue 01, 014002, (January 2008) https://doi.org/10.1117/12.10.1117/1.2839051

KEYWORDS: Optical tweezers, Luminescence, Optical filters, Biological research, Lanthanum, Microscopes, Phase contrast, Lamps, Video, Robotics

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SPIE Journal Paper | 1 March 2007 Open Access

Laser nanosurgery of single microtubules reveals location-dependent depolymerization rates

Nicole Wakida, Christopher Lee, Elliot Botvinick, Linda Shi, Alexander Dvornikov, Michael Berns

JBO, Vol. 12, Issue 02, 024022, (March 2007) https://doi.org/10.1117/12.10.1117/1.2718920

KEYWORDS: Femtosecond phenomena, Picosecond phenomena, Laser ablation, Control systems, Laser cutting, Luminescence, Laser damage threshold, Ultraviolet radiation, Laser systems engineering, Proteins

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Proceedings Article | 11 September 2006 Paper

Mitotic spindle studied using picosecond laser scissors

N. Baker, E. Botvinick, Linda Shi, M. Berns, George Wu

Proceedings Volume 6326, 63262C (2006) https://doi.org/10.1117/12.680965

KEYWORDS: Spindles, Laser ablation, Microscopes, Picosecond phenomena, Microscopy, Mirrors, Luminescence, Cell death, Ultraviolet radiation, Nd:YAG lasers

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SPIE Journal Paper | 1 September 2006 Open Access

Computer-based tracking of single sperm

Linda Shi, Jaclyn Nascimento, Michael Berns, Elliot Botvinick

JBO, Vol. 11, Issue 05, 054009, (September 2006) https://doi.org/10.1117/12.10.1117/1.2357735

KEYWORDS: Particles, Image segmentation, Detection and tracking algorithms, Computing systems, Video, Phase contrast, Image contrast enhancement, Image enhancement, Optical trapping, Biological research

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SPIE Journal Paper | 1 September 2006 Open Access

Errata: Analysis of sperm motility using optical tweezers

Jaclyn Nascimento, Elliot Botvinick, Linda Shi, Barbara Durrant, Michael Berns

JBO, Vol. 11, Issue 05, 059803, (September 2006) https://doi.org/10.1117/12.10.1117/1.2371122

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Proceedings Article | 30 August 2006 Paper

A real-time single sperm tracking, laser trapping, and ratiometric fluorescent imaging system

Linda Shi, Elliot Botvinick, Jaclyn Nascimento, Charlie Chandsawangbhuwana, Michael Berns

Proceedings Volume 6326, 63260V (2006) https://doi.org/10.1117/12.680912

KEYWORDS: Imaging systems, Computing systems, Luminescence, Optical trapping, Video, Telecommunications, Optical filters, Cameras, Image processing, Optical tweezers

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SPIE Journal Paper | 1 July 2006 Open Access

Analysis of sperm motility using optical tweezers

Jaclyn Nascimento, Elliot Botvinick, Linda Shi, Barbara Durrant, Michael Berns

JBO, Vol. 11, Issue 04, 044001, (July 2006) https://doi.org/10.1117/12.10.1117/1.2337559

KEYWORDS: Optical tweezers, Biological research, Optical trapping, Statistical analysis, Microscopes, Principal component analysis, Optical testing, Video, Polarizers, Lanthanum

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