Using phase-sensitive full-field swept-source optical coherence tomography we already showed that morphological changes in the photoreceptor outer segments are detectable. Those signals manifest themselves in an elongation of the optical path length. Using improved post.processing we report on progress in detecting signals in the neuronal layers of the human retina. The spatially resolved signals show a characteristic time course and by combining these with simultaneous measurements of the photoreceptors we were able to generate a wiring map of the neuronal retina.
Non-invasive functional retinal imaging in humans is of tremendous interest. By using phase-sensitive full-field swept-source OCT (FF-SS-OCT) we demonstrated simultaneous quantitative imaging of the optical activation in the photoreceptor and ganglion/inner plexiform layer. Since the signals from the ganglion cells layer are ten-fold smaller than those from the photoreceptor cells a new algorithms for suppression of motion artifacts and pulsatile blood flow in the retinal vessels is important. With improved data evaluation we simultaneously measured the activation of photoreceptors and ganglion/inner plexiform with high quality and were able to analyze the spatial and temporal response of cells in the ganglion/inner plexiform over more than 10 seconds.