Mr. Longfei Zheng Profile

Longfei Zheng

at Wenzhou Medical Univ

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Proceedings Article | 5 January 2017 Paper

Lung cancer diagnosis with quantitative DIC microscopy and support vector machine

Longfei Zheng, Shuangshuang Cai, Bixin Zeng, Min Xu

Proceedings Volume 10245, 102450K (2017) https://doi.org/10.1117/12.2268806

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We report the study of lung squamous cell carcinoma diagnosis using the TI-DIC microscopy and the scattering-phase theorem. The spatially resolved optical properties of tissue are computed from the 2D phase map via the scattering-phase theorem. The scattering coefficient, the reduced scattering coefficient, and the anisotropy factor are all found to increase with the grade of lung cancer. The retrieved optical parameters are shown to distinguish cancer cases from the normal cases with high accuracy. This label-free microscopic approach applicable to fresh tissues may be promising for in situ rapid cancer diagnosis.

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