Adaptive optics optical coherence tomography (AO-OCT) provides depth resolved images of the retina with cellular resolution [1, 2]. So far, various cell types have been visualized with this technique including rod photoreceptors , retinal pigment epithelium cells [3, 4] or Ganglion cells [5, 6]. However, a translation of this technology into clinical settings remains challenging as AOOCT systems are quite bulky and complex to operate. In addition, the clinical benefit of AO-OCT imaging has not yet been demonstrated as especially elderly patients are difficult to image. This presentation gives an overview over the performance of AO-OCT technology in a clinical setting.
We exploit the intrinsic phase stability of akinetic swept source optical coherence tomography to demonstrate digital defocus correction in-vivo at a center wavelength of 1060nm. The high speed of 500kHz enables digital adaptive optics (AO) correction across a field of view of 1.8x1.5deg, currently limited by the employed galvo scanners. The source operates in a previously presented dual resolution mode OCT system (wide field >40deg, AO >3deg) with hardware based adaptive optics. The latter allows to efficiently combine hardware and digital AO, and to further optimize the AO imaging results. We demonstrate the digitally assisted AO performance for both structural imaging as well as for OCT angiography imaging across the full retina down to the choriocapillaris.