Prof. Malathi Srivatsan Profile

Prof. Malathi Srivatsan

at Arkansas State Univ

SPIE Involvement:

Author

Proceedings Article | 24 October 2012 Paper

Synthesis of iron oxide nanotubes and their applications in neuroscience and drug delivery

Linfeng Chen, Jining Xie, Kiran Aatre, Justin Yancey, Malathi Srivatsan, Vijay Varadan

Proceedings Volume 8548, 854867 (2012) https://doi.org/10.1117/12.946051

KEYWORDS: Hematite, Iron, Magnetism, Oxides, Absorbance, Scanning electron microscopy, Neuroscience, Neurons, Transmission electron microscopy, Calibration

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Proceedings Article | 25 April 2011 Paper

Synthesis of hematite and maghemite nanotubes and study of their applications in neuroscience and drug delivery

Linfeng Chen, Jining Xie, Kiran Aatre, Justin Yancey, Sahitya Chetan, Malathi Srivatsan, Vijay Varadan

Proceedings Volume 7980, 798008 (2011) https://doi.org/10.1117/12.881843

KEYWORDS: Hematite, Magnetism, Neurons, Scanning electron microscopy, Absorbance, Iron, Sodium, Calibration, Neuroscience, Crystals

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Proceedings Article | 1 April 2009 Paper

Tubular nanostructured materials for bioapplications

Jining Xie, Linfeng Chen, Malathi Srivatsan, Vijay Varadan

Proceedings Volume 7291, 729103 (2009) https://doi.org/10.1117/12.820762

KEYWORDS: Carbon nanotubes, Hematite, Magnetism, Nanomaterials, Electrodes, Carbon, Glucose, Biomedical optics, Scanning electron microscopy, Nanoparticles

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Proceedings Article | 1 April 2009 Paper

Magnetic nanoparticles and nanotubes for biomedical applications

Linfeng Chen, Jining Xie, Justin Yancey, Malathi Srivatsan, Vijay Varadan

Proceedings Volume 7291, 729108 (2009) https://doi.org/10.1117/12.821550

KEYWORDS: Magnetism, Nanoparticles, Biomedical optics, Nanomaterials, Particles, Nanomedicine, Scanning electron microscopy, Hematite, Nanotechnology, Iron

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Proceedings Article | 28 March 2009 Paper

New materials for old problems: What can nanomaterials do for biology and neuroscience?

Malathi Srivatsan, Mahadevappa Badanavalu, Justin Yancey, Jining Xie, Linfeng Chen, Philip Hankins, Hargsoon Yoon, Vijay Varadan

Proceedings Volume 7291, 729107 (2009) https://doi.org/10.1117/12.820771

KEYWORDS: Magnetism, Neurons, Electrodes, Nanomaterials, Hematite, Neuroscience, Molecules, Glasses, Scanning electron microscopy, Nanowires

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The emerging field of nanotechnology offers the development of new materials and methods for crucial neuroscience applications namely (a) promoting survival and growth of the neurons, and (b) monitoring physiological signals generated in the nervous system such as excitation, synaptic transmission, release of neurotransmitter molecules and cell-to-cell communication. Such bio-devices will have several novel applications in basic science, laboratory analysis and therapeutic treatments. Our goals in this field of research include (a) development of new biocompatible substrates to guide and promote neuronal growth along specific pathways; (b) designing a neuron-friendly, bio-molecule delivery system for neuroprotection; (c) monitoring of electrical activity from neuron and also from neuronal networks; (d) determining the diffusion and intracellular localization of nanomaterial interacting with neurons at high resolution; and (e) detection of release of neurotransmitter molecules by means of newly designed nanosensors. Here we describe the fabrication and use of magnetic nanotubes and nanowire electrode arrays in studies using a cell culture model of neuronally differentiating rat pheochromocytoma (PC 12) cells. The magnetic nanotubes were fabricated by a template method yielding hematite (α-Fe₂O₃) nanotubes. These nanotubes were coupled with nerve growth factor (NGF). Vertically aligned nanowires were fabricated on glass substrates using the lithography-assisted template bonding (LATB) method. Rat pheochromocytoma (PC12) cells were cultured on these nanotubes and polylysine coated nanowire electrodes. Our results showed that magnetic nanotube bound NGF was available to PC12 cells as they showed significant differentiation into neurons. PC12 cells growing on nanowires in the presence of NGF differentiated into neurons capable of synthesis and release of dopamine upon stimulation. The neurons grew healthy neurites appearing to form synapses with other neurons in the dish. These results show that the magnetic nanotubes were capable of delivering neurotrophic molecules and the nanowire electrodes are neuron-friendly, promote cell to cell communication and can be used as bio-sensors in the nervous system.

Proceedings Article | 11 April 2007 Paper

Experimental investigation of magnetic nanotubes in PC-12 neuron cells culturing

Linfeng Chen, Jining Xie, J. Yancey, Malathi Srivatsan, Vijay Varadan

Proceedings Volume 6528, 65280L (2007) https://doi.org/10.1117/12.717970

KEYWORDS: Magnetism, Neurons, Scanning electron microscopy, Transmission electron microscopy, Nervous system, Axons, Nerve, Neuroscience, Glasses, Atomic force microscopy

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Proceedings Article | 31 March 2006 Paper

Magnetic nanotubes and their potential use in neuroscience applications

Linfeng Chen, Jining Xie, Malathi Srivatsan, Vijay Varadan

Proceedings Volume 6172, 61720J (2006) https://doi.org/10.1117/12.668748

KEYWORDS: Magnetism, Neurons, Neuroscience, Scanning electron microscopy, Modulation, Transmission electron microscopy, Nervous system, Iron, Oxides, Molecules

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Showing 5 of 7 publications

Conference Committee Involvement (2)

Nano-, Bio-, Info-Tech Sensors and Systems

7 March 2011 | San Diego, California, United States

Nano-, Bio-, Info-Tech Sensors and Systems

8 March 2010 | San Diego, California, United States

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