A new approach to measure changes of polarization state of the light scattered from a biological object using crosspolarization and polarimetry imagining technique is considered. The method is based on the calculation of the coefficient of residual polarization. Two experimental setups based on incoherent white light source and infrared light source for imaging of the skin pathology with polarimetric detection and processing are developed. The results of two experimental setups are compared and analyzed. The experimental setup based on infrared light source allows one to get better results than the experimental setup based on white light source, because the depth of penetration of infrared radiation is ten times greater than the depth of penetration of visible light.