Typical biological samples are inherently complicated. They may contain a myriad of compounds that are electroactive
at the same potential as that used in many electrochemical biosensors. Therefore, a biosensor design feature must be
included that either eliminates or blocks the interferents from generating false positive signals. The ability to use an
insoluble compound, that of MnO<sub>2</sub>, in order to oxidize interferents such as ascorbic acid, acetaminophen and uric acid,
was investigated in a prototype sensor system at a bias potential of 0.6 V versus Ag/AgCl. Unlike previous work with
these materials, a difference between the ability for the metal oxide to oxidize the interferents was observed. Most
effective was the capability of MnO<sub>2</sub> to oxidize uric acid. Alternatively, the MnO<sub>2</sub> had little effect on acetaminophen.
The study is both introduced and results are discussed within the context of an implantable glucose sensor.