Prof. Martin Villiger Profile

Prof. Martin Villiger

Assistant Professor at Wellman Ctr for Photomedicine

SPIE Involvement:

Conference Program Committee | Author

Publications (75)

Proceedings Article | 13 March 2024 Presentation

Automated volumetric analysis of intravascular polarimetry

Georgia Jones, Kenichiro Otsuka, Brett Bouma, Martin Villiger

Proceedings Volume 12819, 1281904 (2024) https://doi.org/10.1117/12.3002941

KEYWORDS: Polarimetry, Polarization, Tissues, Collagen, Signal processing, Optical coherence tomography, Machine learning, Image segmentation, Image resolution, Diseases and disorders

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Proceedings Article | 13 March 2024 Presentation

Imaging and depth classification of skin microvasculature for skin cancer detection with dynamic laser speckle contrast imaging (DLSCI)

Giulia Mansutti, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume PC12816, PC128160P (2024) https://doi.org/10.1117/12.3002932

KEYWORDS: Skin, Skin cancer, Laser speckle imaging, Cancer detection, Quantum devices, Near infrared, Speckle, Imaging devices, Visible radiation, Tumors

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Proceedings Article | 13 March 2024 Presentation

Demonstration of a combined multispectral FLIm/polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions

Julien Bec, Xiangnan Zhou, Martin Villiger, Brett Bouma, Laura Marcu

Proceedings Volume 12819, 1281908 (2024) https://doi.org/10.1117/12.3003560

KEYWORDS: Optical coherence tomography, Atherosclerosis, Imaging systems, Polarization, Imaging devices, Visualization, Tissues, Pathogens, Natural surfaces, Modulation

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Proceedings Article | 13 March 2024 Presentation

Imaging and mapping local neuroanatomy surrounding a deep brain polarization-sensitive OCT catheter

Shadi Masoumi, Georgia Jones, Mireille Quemener, Martin Parent, Martin Villiger, Daniel Cote, Maxina Sheft

Proceedings Volume PC12830, PC128302H (2024) https://doi.org/10.1117/12.3005514

KEYWORDS: Neuroimaging, Brain, Optical coherence tomography, Brain mapping, White matter, Electrodes, Biological imaging, Tissue optics, Birefringence, Associative arrays

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Proceedings Article | 13 March 2024 Presentation

Sub-macular scleral birefringence in children with myopia measured by triple-input polarization sensitive optical coherence tomography

Xinyu Liu, Parakkel Radhakrishnan, Jacqueline Chua, Quan Hoang, Audrey Chia, Marcus Ang, Seang-Mei Saw, Martin Villiger, Leopold Schmetterer

Proceedings Volume PC12830, PC1283008 (2024) https://doi.org/10.1117/12.3005690

KEYWORDS: Birefringence, Polarization, Optical coherence tomography, Visibility, Statistical analysis, Risk assessment, Design and modelling

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Proceedings Article | 11 August 2023 Paper

Multifunctional catheter-based optical coherence tomography system for oral cavity and endocervical canal imaging

Meng-Shan Wu, Chuan-Bor Chueh, Tai-Ang Wang, Ting-Hao Chen, Ting-Yen Tsai, Brett Bouma, Martin Villiger, Hsiang-Chieh Lee

Proceedings Volume 12632, 1263209 (2023) https://doi.org/10.1117/12.2669338

KEYWORDS: Imaging systems, Optical coherence tomography, Biological imaging, Birefringence, Tongue, Tissues, Polarization, Information architecture, In vivo imaging, Cervix

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Proceedings Article | 11 August 2023 Paper

Practical volumetric speckle reduction in OCT using deep learning

Bhaskara Rao Chintada, Sebastián Ruiz-Lopera, René Restrepo, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume 12632, 126321F (2023) https://doi.org/10.1117/12.2670781

KEYWORDS: Optical coherence tomography, Speckle, Deep learning, Tomography, Neural networks, Image quality, Image enhancement

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Speckle reduction has been an active topic of interest in the Optical Coherence Tomography (OCT) community and several techniques have been developed ranging from hardware-based methods, conventional image-processing and deep-learning based methods. The main goal of speckle reduction is to improve the diagnostic utility of OCT images by enhancing the image quality, thereby enhancing the visual interpretation of anatomical structures. We have previously introduced a probabilistic despeckling method based on non-local means for OCT—Tomographic Non-local-means despeckling (TNode). We demonstrated that this method efficiently suppresses speckle contrast while preserving tissue structures with dimensions approaching the system resolution. Despite the merits of this method, it is computationally very expensive: processing a typical retinal OCT volume takes a few hours. A much faster version of TNode with close to real-time performance, while keeping with the open source nature of TNode, could find much greater use in the OCT community. Deep learning despeckling methods have been proposed in OCT, including variants of conditional Generative Adversarial Networks (cGAN) and convolutional neural networks CNN. However, most of these methods have used B-scan compounding as a ground truth, which presents significant limitations in terms of speckle reduced tomograms with preservation of resolution. In addition, all these methods have focused on speckle suppression of individual B-scans, and their performance on volumetric tomograms is unclear: the expectation is that three-dimensional manipulations of these processed tomograms (i.e., en face projections) will contain artifacts due to the B-scan-wise processing, disrupting the continuity of tissue structures along the slow-scan axis. In addition, speckle suppression based on individual B-scans cannot provide the neural network with information on volumetric structures in the training data, and thus is expected to perform poorly on small structures. Indeed, most deep-learning despeckling works have focused on image quality metrics based on demonstrating strong speckle suppression, rather than focusing on preservation of contrast and small tissue structures. To overcome these problems, we propose an entire workflow to enable the wide-spread use of deep-learning speckle suppression in OCT: the ground-truth is generated using volumetric TNode despeckling, and the neural network uses a new cGAN that receives OCT partial volumes as inputs to utilize the three-dimensional structural information for speckle reduction. Because of its reliance on TNode for generating ground-truth data, this hybrid deep-learning–TNode (DL-TNode) framework will be made available to the OCT community to enable easy training and implementation in a multitude of OCT systems without relying on specialty-acquired training data.

Proceedings Article | 11 August 2023 Paper

Dual-resolution endoscopic OCT in vivo for improved tissue scattering property characterization

T. Cannon, M. Shishkov, G. Schmidt, M. Villiger, B. Bouma, N. Uribe-Patarroyo

Proceedings Volume 12632, 1263208 (2023) https://doi.org/10.1117/12.2670505

KEYWORDS: Optical coherence tomography, Tissues, Scattering, In vivo imaging, Endoscopy, Signal attenuation, Signal intensity, Relays, Particles, Multiple scattering

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Proceedings Article | 17 March 2023 Presentation

Demonstration of a combined multispectral FLIm/ polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions.

Julien Bec, Xiangnan Zhou, Pelham Keahey, Martin Villiger, Brett Bouma, Laura Marcu

Proceedings Volume PC12355, PC1235505 (2023) https://doi.org/10.1117/12.2649672

KEYWORDS: Optical coherence tomography, Polarization, Multispectral imaging, Imaging systems, Imaging devices, Visualization, Tissues, Reflectivity, Pathogens, Optical fibers

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Proceedings Article | 17 March 2023 Presentation

Intravascular polarimetry with existing clinical instruments

Georgia Thomas, Kenichiro Otsuka, Joost Daemen, Brett Bouma, Martin Villiger

Proceedings Volume PC12355, PC123550G (2023) https://doi.org/10.1117/12.2650425

KEYWORDS: Polarimetry, Polarization, Tissues, Optical coherence tomography, Modulation, Visualization, Tissue optics, Statistical analysis, Signal processing, Imaging systems

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Proceedings Article | 17 March 2023 Presentation

Intravascular optical coherence polarimetry

Martin Villiger

Proceedings Volume PC12355, PC1235504 (2023) https://doi.org/10.1117/12.2661500

KEYWORDS: Polarimetry, Coherence (optics), Polarization, Spatial resolution, Scattering, Optical coherence tomography, Integrated optics, Collagen

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Proceedings Article | 17 March 2023 Presentation

Dual-resolution, catheter-based probe for visualization of angular-diverse scattering contrast of esophagus in vivo with optical coherence tomography

Taylor Cannon, Milen Shishkov, Ginger Schmidt, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume PC12356, PC1235609 (2023) https://doi.org/10.1117/12.2650387

KEYWORDS: Scattering, Optical coherence tomography, Visualization, In vivo imaging, Tissues, Scatter measurement, Esophagus, Imaging systems, Endoscopy, Tissue optics

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Proceedings Article | 16 March 2023 Presentation

Progress with coherent endoscopy through multimode fiber (Conference Presentation)

Martin Villiger

Proceedings Volume PC12388, PC123880A (2023) https://doi.org/10.1117/12.2654744

KEYWORDS: Multimode fibers, Endoscopy, Wavefronts, Tomography, Tissues, Tissue optics, Image restoration, Image compression, Confocal microscopy, Coherence imaging

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Proceedings Article | 16 March 2023 Presentation

Enhanced laser speckle perfusion imaging for skin cancer detection at 980 nm with a black silicon camera (Conference Presentation)

Giulia Mansutti, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume PC12393, PC1239305 (2023) https://doi.org/10.1117/12.2650487

KEYWORDS: Cameras, Silicon, Skin cancer, Speckle, Semiconductor lasers, Speckle imaging, Skin, Imaging devices, Tissues, Imaging systems

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Proceedings Article | 9 March 2023 Presentation

In-vivo retinal nerve fiber bundle polarimetry with probabilistic Stokes polarization-sensitive optical coherence tomography

Sebastián Ruiz-Lopera, René Restrepo, Martin Villiger, Brett E. Bouma, Néstor Uribe-Patarroyo

Proceedings Volume PC12367, PC1236711 (2023) https://doi.org/10.1117/12.2653011

KEYWORDS: Polarimetry, Optical coherence tomography, Nerve, In vivo imaging, Tissue optics, Eye, Birefringence, Visualization, Therapeutics, Statistical analysis

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Proceedings Article | 9 March 2023 Presentation

Triple-input polarization sensitive optical coherence tomography improves the birefringence sensitivity by reconstruction of full Mueller matrix of the sample

Xinyu Liu, Liqin Jiang, Jacqueline Chua, Quan Hoang, Bingyao Tan, Valentina Bellemo, Veluchamy Barathi, Martin Villiger, Leopold Schmetterer

Proceedings Volume PC12367, PC1236714 (2023) https://doi.org/10.1117/12.2652928

KEYWORDS: Birefringence, Polarization, Optical coherence tomography, Reconstruction algorithms, Modulation, Tomography, Tissues, Retinal scanning, Ranging, Polarimetry

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Proceedings Article | 9 March 2023 Presentation

Catheter-based polarization sensitive optical coherence tomography with a single input polarization state

Georgia Thomas, Brett Bouma, Martin Villiger

Proceedings Volume PC12367, PC1236713 (2023) https://doi.org/10.1117/12.2652908

KEYWORDS: Polarization, Optical coherence tomography, Tissues, Birefringence, Visualization, Signal processing, Scattering, Scatter measurement, Picosecond phenomena, Modulation

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Proceedings Article | 9 March 2023 Presentation

Angular compounding for physically informed training of speckle suppression algorithms

Pelham Keahey, Brett Bouma, Martin Villiger

Proceedings Volume PC12367, PC1236719 (2023) https://doi.org/10.1117/12.2651586

KEYWORDS: Speckle, Optical coherence tomography, Tissues, Data modeling, Tissue optics, Systems modeling, System identification, Statistical modeling, Speckle pattern, Spatial resolution

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Proceedings Article | 9 March 2022 Presentation

Aging of deep venous thrombosis using polarization sensitive optical coherence tomography

Georgia Thomas, Hassan Albadawi, Rahmi Oklu, Lida Hariri, Brett Bouma, Martin Villiger

Proceedings Volume PC11949, PC119490M (2022) https://doi.org/10.1117/12.2609207

KEYWORDS: Collagen, Birefringence, Optical coherence tomography, Polarization, Therapeutics, In vivo imaging, Tissues, Tissue optics, Process modeling, Image analysis

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Proceedings Article | 7 March 2022 Presentation + Paper

Detection of lipid at video rate with spectroscopic transient-mode photo-thermal optical coherence tomography (TM-PT-OCT)

Mohammad Hossein Salimi, Martin Villiger, Nima Tabatabaei

Proceedings Volume 11948, 119480C (2022) https://doi.org/10.1117/12.2607635

KEYWORDS: Photothermal effect, Optical coherence tomography, Spectroscopy, Collagen, Video, Absorption, Signal to noise ratio, Imaging systems, Laser spectroscopy, Tissues, Optical spectroscopy

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Proceedings Article | 7 March 2022 Presentation

Living tissue imaging using gold nanobipyramid contrast agents and polarization sensitive optical coherence tomography

Pelham Keahey, Peng Si, Martin Villiger, Adam de la Zerda, Brett Bouma

Proceedings Volume PC11948, PC1194818 (2022) https://doi.org/10.1117/12.2612087

KEYWORDS: Optical coherence tomography, Polarization, Tissue optics, Gold, Infrared signatures, Tissues, Speckle, Scattering, Particles, Near infrared

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Proceedings Article | 7 March 2022 Presentation

Intravascular OCT polarimetry: Progress, prospects, and challenges

Martin Villiger, Kenichiro Otsuka, Brett Bouma

Proceedings Volume PC11936, PC1193601 (2022) https://doi.org/10.1117/12.2619302

KEYWORDS: Polarimetry, Optical coherence tomography, Tissue optics, Scattering, Polarization, Optical testing, Collagen, Anisotropy

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Proceedings Article | 7 March 2022 Presentation

Improving single-input polarization-sensitive OCT using maximum likelihood estimation

Georgia Thomas, Brett Bouma, Martin Villiger

Proceedings Volume PC11948, PC119481A (2022) https://doi.org/10.1117/12.2612413

KEYWORDS: Optical coherence tomography, Polarization, Tissues, Statistical analysis, Birefringence, Tissue optics, Reconstruction algorithms, Optimization (mathematics), Modulators, Modulation

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Proceedings Article | 7 March 2022 Presentation

Lung parenchyma biomechanics in pulmonary fibrosis using endobronchial optical coherence tomography elastography imaging: a preliminary investigation

Arash Dadkhah, Sreyankar Nandy, Sarita Berigei, Ashok Muniappan, Amita Sharma, Melissa Suter, Martin Villiger, Corey Hardin, Lida Hariri

Proceedings Volume PC11937, PC119370D (2022) https://doi.org/10.1117/12.2610412

KEYWORDS: Lung, Elastography, Coherence imaging, Pulmonary fibrosis, Optical coherence tomography, In vivo imaging, Tissues, Pathophysiology, Image resolution, Computed tomography

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Proceedings Article | 7 March 2022 Presentation

High fidelity polarization-sensitive optical coherence tomography through deep learning

Ludovick Bégin, Damon DePaoli, Brett Bouma, Daniel Côté, Martin Villiger

Proceedings Volume PC11963, PC119630F (2022) https://doi.org/10.1117/12.2608232

KEYWORDS: Optical coherence tomography, Reconstruction algorithms, Tissue optics, Speckle, Polarization, Data modeling, Birefringence, Tissues, Signal attenuation, Scattering

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Proceedings Article | 7 March 2022 Presentation

In vivo polarization sensitive endobronchial optical coherence tomography for microscopic imaging of fibrotic interstitial lung disease

Sreyankar Nandy, Sarita Berigei, Benjamin Roop, Arash Dadkah, Amita Sharma, Ashok Muniappan, Martin Villiger, Melissa Suter, Lida Hariri

Proceedings Volume PC11937, PC119370F (2022) https://doi.org/10.1117/12.2610296

KEYWORDS: Lung, Optical coherence tomography, In vivo imaging, Polarization, Picosecond phenomena, Visualization, Birefringence, Tissue optics, Surgery, Pulmonary fibrosis

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Proceedings Article | 3 March 2022 Presentation

Feasibility of partially-coherent wide-field laser speckle-based imaging for deep perfusion visualization in assisted intravenous access

Giulia Mansutti, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume PC11974, PC119740C (2022) https://doi.org/10.1117/12.2610192

KEYWORDS: Speckle imaging, Visualization, Silicon, Quantum efficiency, Cameras, Veins, Spatial coherence, Speckle, Sensors, Retina

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Proceedings Article | 2 March 2022 Presentation

Multi-contrast 3D label-free imaging through a multimode fiber without active wave-control

Szu-Yu Lee, Vicente Parot, Brett Bouma, Martin Villiger

Proceedings Volume PC11969, PC1196903 (2022) https://doi.org/10.1117/12.2609641

KEYWORDS: 3D image processing, Stereoscopy, Multimode fibers, Endoscopy, Biomedical optics, Wavefronts, Tissues, Tissue optics, Systems modeling, Speckle pattern

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Proceedings Article | 9 December 2021 Paper

Quantifying scattering contrast in intravascular optical coherence tomography for improved atherosclerotic plaque characterization

Taylor Cannon, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume 11924, 119240F (2021) https://doi.org/10.1117/12.2616023

KEYWORDS: Scattering, Signal attenuation, Backscatter, Optical coherence tomography, Arteries, Tissues, Light scattering, Multiple scattering, Mie scattering, Tissue optics

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Proceedings Article | 9 December 2021 Paper

Development of an opto-thermo-mechanical theoretical model for photothermal optical coherence tomography imaging of multilayered samples

Mohammad Hossein Salimi, Martin Villiger, Nima Tabatabaei

Proceedings Volume 11924, 119240B (2021) https://doi.org/10.1117/12.2616018

KEYWORDS: Optical coherence tomography, 3D modeling, Modulation, Coherence imaging, Statistical modeling, Absorption, Tissues, Optical imaging, Multilayers, Light scattering

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Proceedings Article | 5 March 2021 Presentation

Polarization enhanced spectral contrast for optical coherence tomography

Pelham Keahey, Peng Si, Shangjie Yu, Taylor Cannon, Martin Villiger, Adam de la Zerda, Brett Bouma

Proceedings Volume 11630, 1163013 (2021) https://doi.org/10.1117/12.2577761

KEYWORDS: Optical coherence tomography, Polarization, Multiplexing, Infrared signatures, Tissues, Transmittance, Tissue optics, Near infrared, Nanostructures, Nanoparticles

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Proceedings Article | 5 March 2021 Presentation

Quantitative scattering parameters measured with optical coherence tomography are sensitive to microstructural tissue pathologies

Taylor Cannon, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume 11630, 116301D (2021) https://doi.org/10.1117/12.2577858

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Proceedings Article | 5 March 2021 Presentation

Computational spectral memory enhancement in transmission through complex optical media

Szu-Yu Lee, Vicente Parot, Brett Bouma, Martin Villiger

Proceedings Volume 11652, 116520D (2021) https://doi.org/10.1117/12.2577034

KEYWORDS: Thulium, Spectral calibration, Multispectral imaging, Calibration, Tissue optics, Telecommunications, Optical communications, Multimode fibers, Matrices

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Proceedings Article | 5 March 2021 Presentation

Local optic axis imaging of human skin in vivo reveals collagen architecture in the dermis

Qingyun Li, David Sampson, Martin Villiger

Proceedings Volume 11646, 116460V (2021) https://doi.org/10.1117/12.2577843

KEYWORDS: Tissue optics, Skin, Collagen, In vivo imaging, Tissues, Reconstruction algorithms, Optical coherence tomography, Algorithm development, Polarization, Natural surfaces

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Proceedings Article | 5 March 2021 Presentation

Endoscopic optic-axis mapping of white matter fiber tracts using polarization-sensitive optical coherence tomography

Damon DePaoli, Daniel Côté, Brett Bouma, Martin Villiger

Proceedings Volume 11629, 116290S (2021) https://doi.org/10.1117/12.2577859

KEYWORDS: Optical coherence tomography, Imaging systems, Endoscopy, Brain mapping, Polarization, Brain, Scattering, Neuroimaging, Magnetic resonance imaging, Light scattering

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Proceedings Article | 5 March 2021 Presentation

Multiple scattering anisotropy contrast using localization-diverse OCT

Vicente Parot, Taylor Cannon, Martin Villiger, Néstor Uribe-Patarroyo, Brett Bouma

Proceedings Volume 11657, 116570A (2021) https://doi.org/10.1117/12.2578570

KEYWORDS: Optical coherence tomography, Light scattering, Tissues, Anisotropy, Signal attenuation, Multiple scattering, Scattering, Tissue optics, Optical properties, Opacity

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Proceedings Article | 5 March 2021 Presentation + Paper

New model for understanding the relationship between tissue composition and photothermal optical coherence tomography signals

Mohammadhossein Salimi, Martin Villiger, Nima Tabatabaei

Proceedings Volume 11655, 116550Q (2021) https://doi.org/10.1117/12.2583046

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Proceedings Article | 5 March 2021 Presentation

Computational refocusing in polarization-sensitive optical coherence tomography with phase unstable systems

Sebastián Ruiz-Lopera, René Restrepo, Taylor Cannon, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume 11630, 116300E (2021) https://doi.org/10.1117/12.2583925

KEYWORDS: Optical coherence tomography, Computing systems, Aberration correction, Polarimetry, Image segmentation, Image quality standards, Image quality, Image processing, Image enhancement, Functional imaging

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Proceedings Article | 5 March 2021 Presentation

Multi-object segmentation of anatomical layers in intravascular polarization-sensitive optical coherence tomography using convolutional neural networks

Mohammad Haft-Javaherian, Kenichiro Otsuka, Peter Libby, Polina Golland, Martin Villiger, Brett Bouma

Proceedings Volume 11621, 116210E (2021) https://doi.org/10.1117/12.2578851

KEYWORDS: Optical coherence tomography, Image segmentation, Convolutional neural networks, Polarization, Polarimetry, Multidimensional signal processing, Data modeling, Tissues, Image resolution, Backscatter

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Proceedings Article | 5 March 2021 Presentation

Layer-based approach for determining quantitative scattering parameters of atherosclerotic plaque components using OCT

Taylor Cannon, Néstor Uribe-Patarroyo, Martin Villiger, Brett Bouma

Proceedings Volume 11621, 116210D (2021) https://doi.org/10.1117/12.2577587

KEYWORDS: Signal attenuation, Backscatter, Optical coherence tomography, Tissue optics, Tissues, Optical properties, Light scattering, In vivo imaging, Arteries

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Proceedings Article | 5 March 2021 Presentation

Reconstruction of tissue birefringence from polarization-sensitive optical coherence tomography using machine learning

Ludovick Bégin, Damon DePaoli, Brett Bouma, Daniel Côté, Martin Villiger

Proceedings Volume 11646, 1164612 (2021) https://doi.org/10.1117/12.2578448

KEYWORDS: Tissue optics, Birefringence, Optical coherence tomography, Network architectures, Speckle, Polarization, Machine learning, Tissues, Systems modeling, Statistical modeling

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SPIE Journal Paper | 23 December 2020 Open Access

Effects of lipid composition on photothermal optical coherence tomography signals

Mohammad Hossein Salimi, Martin Villiger, Nima Tabatabaei

JBO, Vol. 25, Issue 12, 120501, (December 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.12.120501

KEYWORDS: Optical coherence tomography, Tissues, Absorption, Modulation, Water, Tissue optics, Nonlinear optics, Molecules, Phase measurement, Coherence (optics)

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SPIE Journal Paper | 10 September 2020 Open Access

Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples

Karol Karnowski, Qingyun Li, Anima Poudyal, Martin Villiger, Camile Farah, David Sampson

JBO, Vol. 25, Issue 09, 096003, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.096003

KEYWORDS: Tissues, Birefringence, Optical coherence tomography, Tissue optics, Pathology, Polarization, In vivo imaging, Tongue, Natural surfaces, Microscopy

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Proceedings Article | 11 March 2020 Presentation

Computational confocal gating through multimode fiber without active wave-control (Conference Presentation)

Szu-Yu Lee, Brett Bouma, Martin Villiger

Proceedings Volume 11248, 112480C (2020) https://doi.org/10.1117/12.2546713

KEYWORDS: Confocal microscopy, Multimode fibers, Geometrical optics, Light wave propagation, Spatial resolution, Reflectivity, Wavefronts, Holography, Digital holography, Active optics

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Proceedings Article | 7 March 2019 Presentation

Local optic axis mapping for airway smooth muscle assessment in catheter-based polarization-sensitive optical coherence tomography (Conference Presentation)

Qingyun Li, Karol Karnowski, Peter Noble, Michael Hackmann, Onur Çetinkaya, Barry Cense, Alan James, Martin Villiger, David Sampson

Proceedings Volume 10854, 108540U (2019) https://doi.org/10.1117/12.2510838

KEYWORDS: Tissue optics, Optical coherence tomography, Birefringence, Associative arrays, Tissues, Collagen, Optical components, Optical alignment, Signal analyzers

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Proceedings Article | 4 March 2019 Presentation

Probing reflectivity profiles with a random sensing matrix (Conference Presentation)

Szu-Yu Lee, Pui-Chuen Hui, Nestor Uribe-Patarroyo, Brett Bouma, Martin Villiger

Proceedings Volume 10886, 108860U (2019) https://doi.org/10.1117/12.2509055

KEYWORDS: Reflectivity, Imaging systems, Mirrors, Sensing systems, Computer architecture, Computer programming, Multimode fibers, Light, Cameras, Holography

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Proceedings Article | 4 March 2019 Presentation

Proximal measurement of multimode fiber transmission matrix (Conference Presentation)

Szu-Yu Lee, Martin Villiger, Brett Bouma

Proceedings Volume 10886, 108860L (2019) https://doi.org/10.1117/12.2509043

KEYWORDS: Multimode fibers, Calibration, Geometrical optics, Endoscopes, Endoscopy, Spatial resolution, Thulium

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Proceedings Article | 4 March 2019 Presentation

Depolarization signatures of multiply scattered light (Conference Presentation)

Pelham Keahey, Felix Fanjul-Velez, Yong-Chul Yoon, Norman Lippok, Brett Bouma, Martin Villiger

Proceedings Volume 10867, 1086712 (2019) https://doi.org/10.1117/12.2510285

KEYWORDS: Light scattering, Optical coherence tomography, Particles, Multiple scattering, Spherical lenses, Crystals, Image resolution, Polarization, Polarimetry, Birefringence

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Proceedings Article | 14 March 2018 Presentation

Assessment of airway smooth muscle layers in human airways with single-measurement, polarization-sensitive OCT (Conference Presentation)

Karol Karnowski, Qingyun Li, Peter Noble, Martin Villiger, Alan James, David Sampson

Proceedings Volume 10470, 1047009 (2018) https://doi.org/10.1117/12.2291222

KEYWORDS: Optical coherence tomography, Polarization, Modulation, Birefringence, Visualization, Human subjects, Multiplexing, Tissues, 3D metrology

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Proceedings Article | 29 April 2017 Paper

Local birefringence of the anterior segment of the human eye in a single capture with a full range polarisation-sensitive optical coherence tomography

Qingyun Li, Karol Karnowski, Martin Villiger, David Sampson

Proceedings Volume 10340, 1034019 (2017) https://doi.org/10.1117/12.2270230

KEYWORDS: Image processing, Range imaging, In vivo imaging, Jones matrices, Mueller matrices, Optical coherence tomography, Image segmentation, Birefringence, Eye, Polarization, Imaging systems, Biological research, Iris recognition, Iris, Tissues

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Proceedings Article | 29 April 2017 Paper

Evaluation of changes in birefringence for samples subjected to various stress sources measured with polarization-sensitive OCT

Karol Karnowski, Qingyun Li, Martin Villiger, David Sampson

Proceedings Volume 10340, 1034016 (2017) https://doi.org/10.1117/12.2270131

KEYWORDS: Birefringence, Tissues, Optical coherence tomography, Polarization, Biomedical optics, Multiplexing, Photoelasticity, Scattering, Image resolution, Cornea, Tissue optics, Latex, Medical imaging, Imaging systems, Liquids

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Proceedings Article | 24 April 2017 Presentation

Investigation of stress-induced birefringence of tissue determined with polarisation sensitive optical coherence tomography (Conference Presentation)

Karol Karnowski, Qingyun Li, Martin Villiger, David Sampson

Proceedings Volume 10067, 100670P (2017) https://doi.org/10.1117/12.2251519

KEYWORDS: Backscatter, Materials science, Polarization, Tissues, Birefringence, Tissue optics, Optical coherence tomography, Cancer, Scattering, Phase measurement

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Proceedings Article | 19 April 2017 Presentation

Birefringence phantoms for polarization sensitive optical coherence tomography (Conference Presentation)

Xinyu Liu, Martin Villiger, Kathy Beaudette, Linbo Liu, Brett Bouma

Proceedings Volume 10053, 100531C (2017) https://doi.org/10.1117/12.2254896

KEYWORDS: Polarized microscopy, Birefringence, Imaging systems, Optical coherence tomography, Polarization, Tissues, Calibration, Backscatter, Image segmentation, Photoelasticity

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Proceedings Article | 19 April 2017 Presentation

Assessment of vascularization and myelination following peripheral nerve repair using angiographic and polarization sensitive optical coherence tomography (Conference Presentation)

Ahhyun Nam, Isabel Chico-Calero, Jeena Easow, Martin Villiger, Jonathan Welt, Jonathan Winograd, Mark Randolph, Robert Redmond, Benjamin Vakoc

Proceedings Volume 10053, 100530M (2017) https://doi.org/10.1117/12.2254910

KEYWORDS: Photomedicine, Nerve, Optical coherence tomography, Angiography, Injuries, Polarization, Picosecond phenomena, Visualization, Microscopes, Birefringence

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Proceedings Article | 21 February 2017 Paper

Optimal selection of laser modulation parameters in photothermal optical coherence tomography

Ashish Gupta, Martin Villiger, Nima Tabatabaei

Proceedings Volume 10067, 1006718 (2017) https://doi.org/10.1117/12.2252779

KEYWORDS: Modulation, Optical coherence tomography, Diffusion, Laser scattering, Image resolution, Absorption, Refractive index, Chromophores, Thermal modeling, Photothermal effect, Photothermal interactions, Molecular imaging, Systems modeling, Spatial resolution, Statistical modeling

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Proceedings Article | 9 May 2016 Presentation

First clinical pilot study with intravascular polarization sensitive optical coherence tomography (Conference Presentation)

Martin Villiger, Antonios Karanasos, Jian Ren, Norman Lippok, Milen Shishkov, Joost Daemen, Nicolas Van Mieghem, Roberto Diletti, Marco Valgimigli, Robert-Jan van Geuns, Peter de Jaegere, Felix Zijlstra, Gijs van Soest, Seemantini Nadkarni, Evelyn Regar, Brett Bouma

Proceedings Volume 9689, 96892O (2016) https://doi.org/10.1117/12.2211463

KEYWORDS: Optical coherence tomography, Polarization, Birefringence, Tissue optics, Tissues, Collagen, Arteries, Picosecond phenomena, Optical fibers, In vivo imaging

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Proceedings Article | 27 April 2016 Presentation

Spectral reconstruction strategies toward generalized-domain optical coherence tomography with a broadband source and a bucket detector (Conference Presentation)

Pui-Chuen Hui, Néstor Uribe-Patarroyo, Martin Villiger, Brett Bouma

Proceedings Volume 9713, 97131O (2016) https://doi.org/10.1117/12.2212745

KEYWORDS: Optical coherence tomography, Sensors, Photodetectors, Optical filters, Electronic filtering, Compressed sensing, Signal detection, Interferometry, Fabry–Perot interferometers, Tunable filters

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Proceedings Article | 27 April 2016 Presentation

Assessment of atherosclerotic plaque collagen content and architecture using polarization-sensitive optical coherence tomography (Conference Presentation)

Pallavi Doradla, Martin Villiger, Diane Tshikudi, Brett Bouma, Seemantini Nadkarni

Proceedings Volume 9689, 96893L (2016) https://doi.org/10.1117/12.2218191

KEYWORDS: Collagen, Optical coherence tomography, Polarization, Birefringence, Macromolecules, Tissue optics, Proteins, Heart, Visualization, Microscopy

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Acute myocardial infarction, caused by the rupture of vulnerable coronary plaques, is the leading cause of death worldwide. Collagen is the primary extracellular matrix macromolecule that imparts the mechanical stability to a plaque and its reduction causes plaque instability. Intracoronary polarization sensitive optical coherence tomography (PS-OCT) measures the polarization states of the backscattered light from the tissue to evaluate plaque birefringence, a material property that is elevated in proteins such as collagen with an ordered structure. Here we investigate the dependence of the PS-OCT parameters on the quantity of the plaque collagen and fiber architecture. In this study, coronary arterial segments from human cadaveric hearts were evaluated with intracoronary PS-OCT and compared with Histopathological assessment of collagen content and architecture from picrosirius-red (PSR) stained sections. PSR sections were visualized with circularly-polarized light microscopy to quantify collagen birefringence, and the additional assessment of color hue indicated fibril thickness. Due to the ordered architecture of thick collagen fibers, a positive correlation between PS-OCT retardation and quantity of thick collagen fibers (r=0.54, p=0.04), and similarly with the total collagen content (r=0.51, p=0.03) was observed. In contrast, there was no perceivable relationship between PS-OCT retardation and the presence of thin collagen fibers (r=0.08, p=0.07), suggesting that thin and disorganized collagen fiber architecture did not significantly contribute to the PS-OCT retardation. Further analysis will be performed to assess the relationship between PS-OCT retardation and collagen architecture based on immunohistochemical analysis of collagen type. These results suggest that intracoronary PS-OCT may open the opportunity to assess collagen architecture in addition total collagen content, potentially enabling an improved understanding of coronary plaque rupture.

Proceedings Article | 26 April 2016 Presentation

Studying airway smooth muscle in vivo with PS-OCT (Conference Presentation)

David Adams, Lida Hariri, Alyssa Miller, Martin Villiger, Jasmin Holz, Margit Szabari, Brett Bouma, Andrew Luster, Benjamin Medoff, Melissa Suter

Proceedings Volume 9697, 96971H (2016) https://doi.org/10.1117/12.2214772

KEYWORDS: In vivo imaging, Optical coherence tomography, Polarization, Birefringence, Photomedicine, Coherence (optics), Biomedical optics, Current controlled current source

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Proceedings Article | 26 April 2016 Presentation

Needle-based polarization-sensitive OCT of breast tumor (Conference Presentation)

Martin Villiger, Dirk Lorenser, Robert McLaughlin, Bryden Quirk, Rodney Kirk, Brett Bouma, David Sampson

Proceedings Volume 9697, 96971E (2016) https://doi.org/10.1117/12.2214773

KEYWORDS: Tissues, Optical coherence tomography, Breast, Tumors, Polarization, Birefringence, Photomedicine, Structural imaging, Tissue optics, Scattering

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Proceedings Article | 26 April 2016 Presentation

Automatic classification of atherosclerotic plaques imaged with intravascular OCT (Conference Presentation)

Jose Rico-Jimenez, Daniel Campos-Delgado, Martin Villiger, Brett Bouma, Javier Jo

Proceedings Volume 9697, 96970B (2016) https://doi.org/10.1117/12.2214563

KEYWORDS: Optical coherence tomography, Image classification, Speckle, Tissues, Tissue optics, Visualization, Scattering, Signal attenuation, Image segmentation, Natural surfaces

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Proceedings Article | 8 March 2016 Presentation + Paper

Ultrahigh resolution optical coherence elastography using a Bessel beam for extended depth of field

Andrea Curatolo, Martin Villiger, Dirk Lorenser, Philip Wijesinghe, Alexander Fritz, Brendan Kennedy, David Sampson

Proceedings Volume 9697, 96971Q (2016) https://doi.org/10.1117/12.2214684

KEYWORDS: Tissue optics, Coherence (optics), Elastography, Optical coherence tomography, Tissues, Optical resolution, Bessel beams, Image enhancement, Image resolution, Spatial resolution, Spatial light modulators

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Proceedings Article | 7 March 2016 Paper

Towards in vivo laser coagulation and concurrent optical coherence tomography through double-clad fiber devices

Kathy Beaudette, William Lo, Martin Villiger, Milen Shishkov, Nicolas Godbout, Brett Bouma, Caroline Boudoux

Proceedings Volume 9701, 97010B (2016) https://doi.org/10.1117/12.2209382

KEYWORDS: Optical coherence tomography, Laser marking, In vivo imaging, Laser coagulation, Cladding, Multimodal imaging, Biopsy, Fiber lasers, Pulsed laser operation, Imaging systems, Zemax, Esophagus, GRIN lenses

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SPIE Journal Paper | 21 September 2012 Open Access

Errata: Frequency domain multiplexing for speckle reduction in optical coherence tomography

Gijs van Soest, Evelyn Regar, Martin Villiger, Guillermo Tearney, Brett Bouma, Antonius van der Steena

JBO, Vol. 17, Issue 9, 099801, (September 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.9.099801

KEYWORDS: Multiplexing, Speckle, Optical coherence tomography, Licensing, Medical research, Patents, Biomedical optics, Photomedicine, Cardiology

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SPIE Journal Paper | 13 July 2012 Open Access

Frequency domain multiplexing for speckle reduction in optical coherence tomography

Gijs van Soest, Evelyn Regar, Antonius van der Steen, Martin Villiger, Guillermo Tearney, Brett Bouma

JBO, Vol. 17, Issue 7, 076018, (July 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.7.076018

KEYWORDS: Speckle, Optical coherence tomography, Signal attenuation, Fused deposition modeling, Image resolution, Multiplexing, Image filtering, Tissues, Data acquisition, Quantitative analysis

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SPIE Journal Paper | 1 November 2011 Open Access

Injury depth control from combined wavelength and power tuning in scanned beam laser thermal therapy

Martin Villiger, Andrew Soroka, Guillermo Tearney, Brett Bouma, Benjamin Vakoc

JBO, Vol. 16, Issue 11, 118001, (November 2011) https://doi.org/10.1117/12.10.1117/1.3647581

KEYWORDS: Injuries, Tissues, Laser therapeutics, Absorption, Laser tissue interaction, Tissue optics, Natural surfaces, Esophagus, Wavelength tuning, 3D modeling

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Proceedings Article | 3 March 2010 Paper

Flicker stimulated retinal perfusion changes assessed with high-speed Doppler tomography

Tilman Schmoll, Amardeep S. Singh, Karine Frily, Cedric Blatter, Martin Villiger, Christoph Pache, Theo Lasser, R. Leitgeb

Proceedings Volume 7550, 75500F (2010) https://doi.org/10.1117/12.842922

KEYWORDS: Doppler tomography, Optical coherence tomography, Algorithm development, Optic nerve, Head, Arteries, Pathology, Pathogens, Functional imaging, Physiology

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Proceedings Article | 20 February 2010 Paper

Dark-field optical coherence microscopy

C. Pache, M. Villiger, T. Lasser

Proceedings Volume 7554, 755425 (2010) https://doi.org/10.1117/12.842848

KEYWORDS: Optical coherence microscopy, Microscopy, Light scattering, Glasses, Interfaces, Signal detection, Objectives, Axicons, Specular reflections, Interferometry

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Proceedings Article | 20 February 2010 Paper

Coherent transfer functions and extended depth of field

M. Villiger, C. Pache, Rainer Leitgeb, Theo Lasser

Proceedings Volume 7554, 755417 (2010) https://doi.org/10.1117/12.840819

KEYWORDS: Contrast transfer function, Signal detection, Focus stacking, Spatial frequencies, Axicons, Optical coherence microscopy, Spectroscopy, Objectives, Point spread functions, Lenses

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Proceedings Article | 14 July 2009 Paper

In vivo imaging of pancreatic endocrine islets

Martin Villiger, Joan Goulley, Christophe Pache, Michael Friedrich, Anne Grapin-Botton, Paolo Meda, Rainer Leitgeb, Theo Lasser

Proceedings Volume 7372, 73720E (2009) https://doi.org/10.1117/12.831864

KEYWORDS: Pancreas, In vivo imaging, Tissues, Axicons, Scanners, Visualization, Glucose, Signal detection, Blood vessels, 3D image processing

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Proceedings Article | 20 February 2008 Paper

Extended focus optical coherence microscopy and fluorescence lifetime imaging

Martin Villiger, Cedric Blatter, Adrian Bachmann, Theo Lasser, Rainer Leitgeb

Proceedings Volume 6861, 68610N (2008) https://doi.org/10.1117/12.763163

KEYWORDS: Fluorescence lifetime imaging, Luminescence, Axicons, Objectives, Mirrors, Optical coherence microscopy, Modulation, Signal detection, Focus stacking, Relays

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Proceedings Article | 11 July 2007 Paper

Intensity-based quantification of fast retinal blood flow in 3D via high resolution resonant Doppler spectral OCT

R. Michaely, A. Bachmann, M. Villiger, C. Blatter, T. Lasser, R. Leitgeb

Proceedings Volume 6627, 66270J (2007) https://doi.org/10.1117/12.728473

KEYWORDS: Doppler tomography, Signal attenuation, Optical coherence tomography, Blood circulation, Doppler effect, Blood vessels, 3D image processing, Optic nerve, Head, Cameras

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Proceedings Article | 11 July 2007 Paper

Extended focus Fourier domain optical coherence microscopy assists developmental biology

Martin Villiger, Manfred Beleut, Cathrin Brisken, Theo Lasser, Rainer Leitgeb

Proceedings Volume 6627, 66271H (2007) https://doi.org/10.1117/12.728370

KEYWORDS: Mammary gland, Axicons, Tissues, In vivo imaging, Optical coherence tomography, Optical coherence microscopy, Green fluorescent protein, Space telescopes, Biology, Microscopy

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SPIE Journal Paper | 1 July 2007 Open Access

Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography

Roland Michaely, Adrian Bachmann, Martin Villiger, Cedric Blatter, Theo Lasser, Rainer Leitgeb

JBO, Vol. 12, Issue 04, 041213, (July 2007) https://doi.org/10.1117/12.10.1117/1.2771553

KEYWORDS: Blood circulation, Doppler tomography, Signal attenuation, Optical coherence tomography, Doppler effect, Cameras, 3D image processing, Reconstruction algorithms, Image segmentation, Signal to noise ratio

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Proceedings Article | 5 March 2007 Paper

Measurement of retinal physiology using functional Fourier domain OCT concepts

R. Leitgeb, A. Bachmann, M. Villiger, R. Michaely, C. Blatter, T. Lasser, C. Pache, M. Pircher

Proceedings Volume 6426, 642609 (2007) https://doi.org/10.1117/12.702232

KEYWORDS: Doppler effect, Optical coherence tomography, Spectroscopy, Physiology, Functional imaging, Tissue optics, Blood circulation, Polarization, Doppler tomography, Tissues

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Showing 5 of 75 publications

Conference Committee Involvement (2)

Diagnostic and Therapeutic Applications of Light in Cardiology 2025

25 January 2025 | San Francisco, United States

Diagnostic and Therapeutic Applications of Light in Cardiology 2024

27 January 2024 | San Francisco, California, United States

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