Dr. Mary-Ann Mycek
Professor of Biomedical Engineering at Univ of Michigan
SPIE Involvement:
Conference Program Committee | Author
Area of Expertise:
Biomedical Optics , Optical Molecular Imaging , Clinical Optical Diagnostics , Computational Modeling
Profile Summary


In my Biomedical Optical Diagnostics Laboratory, our objective is to improve human health through research and education in Biomedical Optics, a multidisciplinary field incorporating elements of the physical and life sciences, engineering, and medicine.

My translational (“bench to bedside”) research program in Biomedical Optics involves developing and applying methods of optical science and engineering to quantitatively probe living cells and tissues, with the goal of impacting patient care via the development of non- and minimally-invasive biomedical optical diagnostic technologies.

To achieve this goal, the research strategy I employ has three major approaches, which proceed in parallel and are closely related to one another: (1) Optical Molecular Imaging (basic, pre-clinical studies on model systems); (2) Clinical Optical Diagnostics (applied, clinical studies on human tissues); (3) Computational Modeling (quantitative, theoretical models of light propagation in tissues).

My research interests include: biomedical optical tissue spectroscopy and imaging; nonlinear and time- resolved optical spectroscopy and imaging methods; ultrafast cellular and molecular imaging and sensing at the micro- and nano-scales; non- and minimally-invasive biological sensing; computational modeling of light-tissue interactions.
Publications (50)

Proceedings Article | 3 March 2022 Paper
Carter McMaster, Michael Helton, Boyd Colbrunn, Mary-Ann Mycek, Karthik Vishwanath
Proceedings Volume 11974, 119740C (2022) https://doi.org/10.1117/12.2610392
KEYWORDS: Optical phantoms, Tissue optics, Diffuse reflectance spectroscopy, Absorption, Scattering

Proceedings Article | 5 March 2021 Presentation + Paper
Proceedings Volume 11647, 1164704 (2021) https://doi.org/10.1117/12.2578759
KEYWORDS: Second-harmonic generation, Microscopy, Harmonic generation, Spatial resolution, Scattering, Image processing, Image analysis, Tissues, In vivo imaging, In vitro testing

Proceedings Article | 5 March 2021 Presentation + Paper
Proceedings Volume 11657, 116570M (2021) https://doi.org/10.1117/12.2583283
KEYWORDS: Calibration, Diffusion, Diffuse optical spectroscopy, Optical properties, Reflectivity, Tissue optics, Scattering, Optical components, Monte Carlo methods, Absorption

Proceedings Article | 21 February 2020 Paper
Proceedings Volume 11253, 112530O (2020) https://doi.org/10.1117/12.2543610
KEYWORDS: Monte Carlo methods, Optical properties, Scattering, Absorption, Tissues, Diffuse reflectance spectroscopy, Reflectivity, Picosecond phenomena, Sensors, Point spread functions

Proceedings Article | 14 March 2018 Presentation
William Lloyd, Seung Yup Lee, Sakib Elahi, Leng-Chun Chen, Shiuhyang Kuo , Hyungjin Myra Kim Kim , Cynthia Marcelo, Stephen Feinberg, Mary-Ann Mycek
Proceedings Volume 10489, 1048913 (2018) https://doi.org/10.1117/12.2292033
KEYWORDS: Tissue optics, Diffuse reflectance spectroscopy, In vitro testing, In vivo imaging, Manufacturing, Microscopy, Tissue engineering, Regenerative medicine, Light wave propagation, Diagnostics

Showing 5 of 50 publications
Proceedings Volume Editor (2)

SPIE Conference Volume | 19 August 2005

Conference Committee Involvement (31)
Biomedical Light Scattering XV
25 January 2025 | San Francisco, California, United States
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXIII
25 January 2025 | San Francisco, California, United States
SPIE Translational Biophotonics + Additive Manufacturing for Photonics 2024
16 September 2024 | Houston, Texas, United States
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII
29 January 2024 | San Francisco, California, United States
Biomedical Applications of Light Scattering XIV
27 January 2024 | San Francisco, California, United States
Showing 5 of 31 Conference Committees
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