Prof. Masami Ando Profile

Prof. Masami Ando

at High Energy Accelerator Research Organization

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Author

Publications (10)

Proceedings Article | 13 July 2009 Paper

Photodynamic synchrotron x-ray therapy in glioma cell using superparamagnetic iron nanoparticle

Hong-Tae Kim, Ki-Hong Kim, Gi-Hwan Choi, Sanghoon Jheon, Sung-Hwan Park, Bong-Il Kim, Kazuyuki Hyodo, Masami Ando, Jong-Ki Kim

Proceedings Volume 7380, 73802P (2009) https://doi.org/10.1117/12.822919

KEYWORDS: X-rays, Nanoparticles, Photodynamic therapy, Iron, Tumors, Particles, Acquisition tracking and pointing, Synchrotrons, Absorbance, Microscopy

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In order to evaluate cytotoxic effects of secondary Auger electron emission(Photon Activation Therapy:PAT) from alginate-coated iron nanoparticles(Alg-SNP), Alg-SNP-uptaken C6 glioma cell lines were irradiated with 6.89/7.2 Kev synchrotron X-ray. 0-125 Gy were irradiated on three experimental groups including No-SNP group incubating without SNP as control group, 6hr-SNP group incubating with SNP for 6hr and ON-SNP group incubating with SNP overnight. Irradiated cells were stained with Acridine Orange(AO) and Edithium Bromide(EB) to count their viability with fluorescent microscopy in comparison with control groups. AO stained in damaged DNA, giving FL color change in X-ray plus SNP group. EB did not or less enter inside the cell nucleus of control group. In contrast, EB entered inside the cell nucleus of Alg-SNP group which means more damage compared with Control groups. The results of MTT assay demonstrated a X-ray dose-dependent reduction generally in cell viability in the experimental groups. 3 or 9 times increase in cell survival loss rate was observed at 6hr-SNP and ON-SNP groups, respectively compared to No-SNP control group in first experiment that was done to test cell survival rate at relatively lower dose, from 0 to 50 Gy. In second experiment X-ray dose was increased to 125 Gy. Survival loss was sharply decreased in a relatively lower dose from 5 to 25 Gy, and then demonstrated an exponentially decreasing behavior with a convergence until 125 Gy for each group. This observation suggests PAT effects on the cell directly by X-ray in the presence of Alg-SNP occurs within lower X-ray dose, and conventional X-ray radiation effect becomes dominant in higher X-ray dose. The cell viability loss of ON-SNP group was three times higher compared with that of 6hr-SNP group. In conclusion, it is possible to design photodynamic X-ray therapy study using a monochromatic x-ray energy and metal nanoparticle as x-ray sensitizer, which may enable new X-ray PDT to disseminated tumors without side effects to normal surrounding tissue.

Proceedings Article | 2 March 2006 Paper

Application of x-ray computed tomography based on the refraction contrast to biomedicine

Eiko Hashimoto, Anton Maksimenko, Hiroshi Sugiyama, Kazuyuki Hyodo, Daisuke Shimao, Tetsuya Yuasa, Yoshinori Nishino, Tetsuya Ishikawa, Koichi Mori, Yoshinori Arai, Keiichi Hirano, Masami Ando

Proceedings Volume 6142, 614213 (2006) https://doi.org/10.1117/12.654313

KEYWORDS: X-rays, Refraction, X-ray computed tomography, X-ray imaging, Tissues, Absorption, Bone, Visualization, Breast cancer, X-ray diffraction

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Proceedings Article | 2 March 2006 Paper

First attempt of the medical application of the refraction-based computed tomography

Anton Maksimenko, Eiko Hashimoto, Masami Ando, Hiroshi Sugiyama, Tetsuya Yuasa

Proceedings Volume 6142, 61423Q (2006) https://doi.org/10.1117/12.652036

KEYWORDS: Refraction, X-rays, X-ray computed tomography, Absorption, Computed tomography, X-ray imaging, Breast cancer, Nondestructive evaluation, Data acquisition, Diffraction

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Proceedings Article | 20 April 2005 Paper

X-ray dark-field imaging and potential of its clinical application

Daisuke Shimao, Hiroshi Sugiyama, Toshiyuki Kunisada, Anton Maksimenko, Fukai Toyofuku, Ei Ueno, Katsuhito Yamasaki, Chiho Obayashi, Kazuyuki Hyodo, Gang Li, Lin Pan, Xiaoming Jiang, Masami Ando

Proceedings Volume 5745, (2005) https://doi.org/10.1117/12.595021

KEYWORDS: X-rays, X-ray imaging, Cartilage, Absorption, Diffraction, Tissues, Breast cancer, X-ray diffraction, Refractive index, Reflectivity

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Proceedings Article | 20 April 2005 Paper

Improving the contrast resolution of DEI image using the resolution-tunable double-crystal analyzer

Gang Li, K. Hirano, Xiaoming Jiang, Zhihua Chen, Ziyu Wu, M. Ando, Lin Pan, Jintian Tang, Peiping Zhu, Ruola Ning

Proceedings Volume 5745, (2005) https://doi.org/10.1117/12.594867

KEYWORDS: X-rays, Crystals, Image resolution, X-ray imaging, Refraction, Diffraction, Kidney, Spatial resolution, X-ray diffraction, Statistical analysis

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Proceedings Article | 6 October 1999 Paper

Proposal for medical application beamlines of the SPring-8

Chikao Uyama, Kenji Tokumori, Fukai Toyofuku, Hiroshi Sugiyama, Kazuyuki Hyodo, Masami Ando, Katsuyuki Nishimura, Tohoru Takeda, Katsuhito Yamasaki, Masao Matsumoto

Proceedings Volume 3770, (1999) https://doi.org/10.1117/12.368181

KEYWORDS: X-rays, X-ray imaging, Light sources, X-ray computed tomography, Monochromators, Angiography, X-ray detectors, X-ray sources, Biomedical optics, Brain-machine interfaces

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Proceedings Article | 6 October 1999 Paper

Fan-beam monochromatic x-ray CT using fluorescent x rays excited by synchrotron radiation

Fukai Toyofuku, Kenji Tokumori, Shigenobu Kanda, Yoshiharu Higashida, Masafumi Ohki, Tetsuji Cho, Katsuyuki Nishimura, Kazuyuki Hyodo, Masami Ando, Chikao Uyama

Proceedings Volume 3770, (1999) https://doi.org/10.1117/12.368188

KEYWORDS: X-rays, X-ray computed tomography, Sensors, X-ray imaging, Synchrotron radiation, Detector arrays, Absorption, Iodine, X-ray sources, Holmium

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Proceedings Article | 6 October 1999 Paper

Development of the photon-counting 256ch CdTe line detector

Kenji Tokumori, Fukai Toyofuku, Shigenobu Kanda, Sueki Baba, Yoshio Mito, Kazuyuki Hyodo, Masami Ando, Chikao Uyama

Proceedings Volume 3770, (1999) https://doi.org/10.1117/12.368180

KEYWORDS: Sensors, X-rays, X-ray detectors, Synchrotron radiation, X-ray sources, X-ray computed tomography, X-ray imaging, Calibration, Detector development, Detector arrays

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SPIE Journal Paper | 1 August 1998

Three-dimensional monochromatic x-ray computed tomography using synchrotron radiation

Tsuneo Saito, Hiroyuki Kudo, Tohoru Takeda, Yuji Itai, Kenji Tokumori, Fukai Toyofuku, Kazuyuki Hyodo, Masami Ando, Katsuyuki Nishimura, Chikao Uyama

OE, Vol. 37, Issue 08, (August 1998) https://doi.org/10.1117/12.10.1117/1.601745

KEYWORDS: X-ray computed tomography, X-rays, Reconstruction algorithms, 3D image processing, X-ray sources, Barium, Synchrotron radiation, Algorithm development, X-ray imaging, Radon transform

Proceedings Article | 22 August 1995 Paper

Three-dimensional monochromatic x-ray CT

Tsuneo Saito, Hiroyuki Kudo, Tohoru Takeda, Yuji Itai, Kenji Tokumori, Fukai Toyofuku, Kazuyuki Hyodo, Masami Ando, Ktsuyuki Nishimura, Chikao Uyama

Proceedings Volume 2564, (1995) https://doi.org/10.1117/12.217441

KEYWORDS: X-ray computed tomography, 3D image processing, Reconstruction algorithms, X-rays, 3D image reconstruction, X-ray sources, X-ray imaging, Synchrotron radiation, Algorithm development, 3D acquisition

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Showing 5 of 10 publications

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