Prof. Matthew D. Lew Profile

Prof. Matthew D. Lew

Associate Professor at Washington Univ in St Louis

SPIE Involvement:

Author | Student Chapter Advisor

Area of Expertise:

nanoscale sensing , super-resolution microscopy , single-molecule spectroscopy , optimal imaging system design

Websites:

Company Website | Personal Website

Read more about my lab's research at https://lewlab.wustl.edu.

Proceedings Article | 12 March 2024 Presentation + Paper

6D single-fluorogen orientation-localization microscopy for elucidating the architecture of beta-sheet assemblies and biomolecular condensates

Tingting Wu, Weiyan Zhou, Jai Rudra, Rohit Pappu, Matthew Lew

Proceedings Volume 12853, 1285302 (2024) https://doi.org/10.1117/12.3005992

KEYWORDS: Molecules, Microscopy, Biomolecules, Microscopes, Fluorescence, Fluorophores, Super resolution microscopy

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Proceedings Article | 13 February 2020 Paper

Measuring localization confidence for quantifying accuracy and heterogeneity in single-molecule super-resolution microscopy

Hesam Mazidi, Tianben Ding, Arye Nehorai, Matthew Lew

Proceedings Volume 11246, 1124611 (2020) https://doi.org/10.1117/12.2545033

KEYWORDS: Molecules, Photons, Point spread functions, Data modeling, Mathematical modeling, Super resolution microscopy, Cameras, Reconstruction algorithms, Computational imaging

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Proceedings Article | 13 February 2020 Paper

A computationally-efficient bound for the variance of measuring the orientation of single molecules

Tingting Wu, Tianben Ding, Hesam Mazidi, Oumeng Zhang, Matthew Lew

Proceedings Volume 11246, 1124616 (2020) https://doi.org/10.1117/12.2543813

KEYWORDS: Point spread functions, Photons, Polarization, Molecules, Modulation, Imaging systems, Super resolution microscopy, Precision processing technology

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Proceedings Article | 22 February 2019 Presentation + Paper

Long-term, super-resolution imaging of amyloid structures using transient amyloid binding microscopy

Tianben Ding, Kevin Spehar, Jan Bieschke, Matthew Lew

Proceedings Volume 10884, 108840J (2019) https://doi.org/10.1117/12.2507656

KEYWORDS: Microscopy, Molecules, Super resolution, Luminescence, Proteins, Microscopes, Image resolution, Visualization, Cameras

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Proceedings Article | 22 February 2019 Paper

Fundamental limits of measuring single-molecule rotational mobility

Oumeng Zhang, Matthew Lew

Proceedings Volume 10884, 1088412 (2019) https://doi.org/10.1117/12.2506712

KEYWORDS: Molecules, Point spread functions, Polarization, Signal to noise ratio

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Proceedings Article | 20 February 2018 Presentation + Paper

Measuring 3D molecular orientation and rotational mobility using a Tri-spot point spread function

Oumeng Zhang, Tianben Ding, Jin Lu, Hesam Mazidi, Matthew Lew

Proceedings Volume 10500, 105000B (2018) https://doi.org/10.1117/12.2287004

KEYWORDS: Point spread functions, Molecules, Photons, Microscopes, Imaging systems, Diffraction, Super resolution

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Proceedings Article | 20 February 2018 Presentation + Paper

A robust statistical estimation (RoSE) algorithm jointly recovers the 3D location and intensity of single molecules accurately and precisely

Hesam Mazidi, Arye Nehorai, Matthew Lew

Proceedings Volume 10500, 105000E (2018) https://doi.org/10.1117/12.2289994

KEYWORDS: Molecules, Point spread functions, Statistical analysis, Photodetectors, Deconvolution, 3D image processing, 3D modeling, Microscopy, Super resolution microscopy, Algorithms

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Proceedings Article | 14 February 2018 Paper

Speckle-modulation for speckle reduction in optical coherence tomography

Orly Liba, Matthew Lew, Elliott SoRelle, Rebecca Dutta, Debasish Sen, Darius Moshfeghi, Steven Chu, Adam de la Zerda

Proceedings Volume 10483, 104832D (2018) https://doi.org/10.1117/12.2289405

KEYWORDS: Dermatology, Optical coherence tomography, Speckle, Speckle pattern, Image resolution, Cornea, Diagnostics

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Proceedings Article | 4 March 2014 Paper

Single-molecule orientation measurements with a quadrated pupil

Adam Backer, Mikael Backlund, Matthew Lew, Alexander Diezmann, Steffen Sahl, W. Moerner

Proceedings Volume 8950, 89500L (2014) https://doi.org/10.1117/12.2042097

KEYWORDS: Molecules, Microscopes, Spatial light modulators, Objectives, Polarization, Photons, Imaging systems, Luminescence, Optical aberrations, Microscopy

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Proceedings Article | 22 February 2013 Paper

The double-helix point spread function enables precise and accurate measurement of 3D single-molecule localization and orientation

Mikael Backlund, Matthew Lew, Adam Backer, Steffen Sahl, Ginni Grover, Anurag Agrawal, Rafael Piestun, W Moerner

Proceedings Volume 8590, 85900L (2013) https://doi.org/10.1117/12.2001671

KEYWORDS: Molecules, Polarization, Microscopy, Super resolution, 3D metrology, Point spread functions, Microscopes, Luminescence, Spatial light modulators, Diffraction

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Proceedings Article | 25 February 2010 Paper

In vivo three-dimensional superresolution fluorescence tracking using a double-helix point spread function

Matthew Lew, Michael Thompson, Majid Badieirostami, W. E. Moerner

Proceedings Volume 7571, 75710Z (2010) https://doi.org/10.1117/12.842608

KEYWORDS: Point spread functions, Quantum dots, Photons, Microscopes, Luminescence, Super resolution, Imaging systems, Microscopy, 3D image processing, Electron multiplying charge coupled devices

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Proceedings Article | 29 February 2008 Paper

Two-dimensional differential interference contrast microscopy based on four-hole variation of Young's interference

Matthew Lew, Xiquan Cui, Xin Heng, Changhuei Yang

Proceedings Volume 6859, 685916 (2008) https://doi.org/10.1117/12.760118

KEYWORDS: Spiral phase plates, Microscopy, Optical vortices, Digital image correlation, Photomasks, Image sensors, CMOS sensors, Phase imaging, Phase measurement, Metals

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Proceedings Article | 19 February 2007 Paper

On-chip differential interference contrast (DIC) phase imager and beam profiler based on Young’s interference

Xiquan Cui, Matthew Lew, Xin Heng, Changhuei Yang

Proceedings Volume 6441, 64411F (2007) https://doi.org/10.1117/12.699920

KEYWORDS: Digital image correlation, Spiral phase plates, Optical vortices, Phase imaging, Gaussian beams, Imaging devices, Wavefronts, Profiling, Aluminum, Optical components

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