Dr. Matthias C. Hofmann Profile

Dr. Matthias C. Hofmann

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Proceedings Article | 13 March 2013 Paper

Diagnosing breast cancer using independent diffuse optical tomography and x-ray mammography scans

Maxim Fradkin, Matthias Hofmann, Jean-Michel Rouet, Richard Moore, Daniel Kopans, Keith Tipton, Sankar Suryanarayanan, David Boas, Qianqian Fang

Proc. SPIE. 8574, Multimodal Biomedical Imaging VIII

KEYWORDS: Breast, X-ray optics, Breast cancer, Tissues, X-rays, Image registration, Mammography, Tissue optics, Digital mammography, Digital breast tomosynthesis

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We have previously demonstrated the utilization of spatially co-registered diffuse optical tomography (DOT) and digital breast tomosynthesis (DBT) for joint breast cancer diagnosis. However, clinical implementation of such a multi-modality approach may require development of integrated DOT/DBT imaging scanners, which can be costly and time-consuming. Exploring effective image registration methods that combine the diagnostic information from a standalone DOT measurement and a separate mammogram can be a cost-effective solution, which may eventually enable adding functional optical assessment to all previously installed digital mammography systems. In this study, we investigate a contour-based image registration method to convert independent optical and x-ray scans into co-registered datasets that can benefit from a joint image analysis. The breast surface used in 3D optical DOT reconstruction is registered with the breast contour line extracted from an x-ray mammogram acquired separately. This allows us to map the 2D mammogram to the optical measurement space and build structural constraints for optical image reconstruction. A non-linear reconstruction utilizing structure-priors is then performed to produce hemoglobin maps with improved resolution. To validate this approach, we used a set of tumor patient measurements with simultaneous DOT/DBT and separate 2D mammographic scans. The images recovered from the registration procedure derived from DOT and 2D mammogram present similar image quality compared to those recovered from co-registered DOT/DBT measurements.

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