Mehrana Mohtasebi
SPIE Involvement:
Profile Summary

I am a Ph.D. candidate in the F. Joseph Halcomb III, M.D. Department of Biomedical Engineering (BME), and has been awarded a Predoctoral Fellowship by the American Heart Association (AHA) in 2021 to continue my research project titled “Mapping Brain Functional Connectivity Using Speckle Contrast Diffuse Correlation Tomography (scDCT).”
I am working on the development of a speckle contrast diffuse correlation tomography (scDCT) system to measure the 3D imaging of cerebral blood flow (CBF) distribution in perinatal disease models. Our results showed that scDCT is able to effectively identify brain hemodynamic disruptions, like CBF reduction. We used neonatal piglets to evaluate the scDCT system. In particular, the transient global ischemia was induced in one neonatal piglet, an intraventricular hemorrhage was stimulated in another piglet, and a hypoxic challenge was administered to instigate perinatal asphyxia in the piglets after CBF was reestablished. The scDCT system was used to determine CBF during global ischemia, intraventricular hemorrhage, and asphyxia, and also produce 3D images of blood flow distributions. Our innovative scDCT was tested in a rat model of transient ischemic stroke. Ischemic stroke may result in cerebral injury, neurologic deficit, and disrupted cerebral functional connectivity.
I am working on mapping Resting-state functional connectivity (RSFC) using scDCT data. RSFC is assessed by imaging of spontaneous LFOs over brain neurovascular networks. The feasibility of scDCT for noninvasive detection of LFOs alteration and RSFC disruption after transient ischemic stroke is demonstrated.
The scDCT system importantly addresses the need for a portable, bedside neuroimaging technology that is capable of continuously measuring CBF and brain function alterations, thereby enabling the evaluation of brain health and the improvement of clinical decisions and outcomes in critically ill newborn infants.
Publications (9)

Proceedings Article | 13 March 2024 Presentation
Faezeh Akbari, Fatemeh Hamedi, Mehrana Mohtasebi, Faraneh Fathi, Chong Huang, Lei Chen, Guoqiang Yu
Proceedings Volume PC12827, PC128270P (2024)
KEYWORDS: Physical coherence, Laser stabilization, Tomography, Speckle, Laser crystals, Signal to noise ratio, Optical coherence, Laser speckle contrast imaging, Image restoration, Crystals

Proceedings Article | 13 March 2024 Presentation
Fatemeh Hamedi, Chong Huang, Faezeh Akbari, Xuhui Liu, Mehrana Mohtasebi, Chaebeom Yeo, Lei Chen, Guoqiang Yu
Proceedings Volume PC12827, PC128270E (2024)
KEYWORDS: Miniaturization, Tomography, Speckle, Cerebral blood flow, Portability, Brain, Neuroimaging, Equipment, Cameras, Brain mapping

SPIE Journal Paper | 14 November 2023 Open Access
NPh, Vol. 10, Issue 04, 045007, (November 2023)
KEYWORDS: Speckle, Laser speckle contrast imaging, Windows, Brain mapping, Simulation of CCA and DLA aggregates, Brain, 3D modeling, Spatial resolution, Tissues, Neurophotonics

SPIE Journal Paper | 4 May 2023 Open Access
JBO, Vol. 28, Issue 12, 121204, (May 2023)
KEYWORDS: Brain, Ischemia, Simulation of CCA and DLA aggregates, Windows, Speckle, 3D image reconstruction, Sampling rates, Tissues, Reconstruction algorithms, Neuroimaging

Proceedings Article | 7 March 2022 Presentation
Proceedings Volume PC11944, PC119440G (2022)
KEYWORDS: Laser speckle contrast imaging, Pulsed laser operation, Picosecond phenomena, Imaging systems, Cerebral blood flow, Continuous wave operation, Diffusers, System integration, Laser crystals, Glasses

Showing 5 of 9 publications
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