It is generally believed that there are some connections between Alzheimer’s disease and amyloid protein plaques in the brain. The typical symptoms of Alzheimer’s disease are memory loss, language disorders, mood swings, loss of motivation and behavioral issues. Currently, the main therapeutic method is pharmacotherapy, which may temporarily reduce symptoms, but has many side effects. Infrared light therapy has been studied in a range of single and multiple irradiation protocols in previous studies and was found beneficial for neuropathology. In our research we have studied the effect of infrared light on Alzheimer’s disease through transgenic mouse model. We designed an experimental apparatus for treating mice, which primarily included a therapeutic box and a LED array, which emitted infrared light. After the treatment, we assessed the effects of infrared light by performing two tests: cognitive performance of mice in Morris water maze, and plaque load by immunofluorescence analysis. Immunofluorescence analysis was based on measuring the quantity of plaques in mouse brain slices. Our results show that infrared therapy is able to improve cognitive performance in the mouse model. It might provide a novel and safe way to treat Alzheimer’s disease.
We experimentally investigated the polarization vector characteristics in an Er-doped fiber laser based on graphene that was deposited on microfiber. A variety of dynamic states, including polarization locked fundamental soliton, and polarization domain wall square pulses and their harmonic mode locked counterparts have all been observed with different pump powers and polarization states. These results indicated that the microfiber-based graphene not only could act as a saturable absorber but also could provide high nonlinearity, which is favorable for the cross coupling between the two orthogonal polarization components. It was worth to mention that it is the first time to obtain the polarization domain wall solitons in a mode locked fiber laser.
We demonstrated the formation of noise-like square-wave pulses in an Er-doped fiber laser, using a microfiber based topological insulator as a saturated absorber (SA). The SA guaranteed both excellent saturable absorption and high nonlinearity. The pulse width can be increased ranging from 0.985 to 5.503 ns by increasing the pump power from 212 to 284 mW with the polarization state fixed. Moreover, with the adjustment of the polarization controllers in the cavity, the pulse width can be adjusted obviously. Worth mentioning, it was the first time that the noise-like square-wave pulse formed in a microfiber based topological insulator fiber laser.
We experimentally generated the duration-controllable square-wave pulse from an L band dissipative soliton (DS) fiber laser based on the dispersive Fourier transformation (DFT) technique. The rectangular spectrum emitted from an L band dissipative soliton fiber laser is mapped into a time-domain coherent rectangular waveform through the DFT technique. The duration of the square-wave pulse can be controllable with the adjustments of the pump power. The results demonstrate that it is an effective and flexible way to achieve duration-controllable square-wave pulses by combinating with DFT technique and DS fiber laser.
Alzheimer's disease (AD) is an extensive neurodegenerative disease. It is generally believed that there are some connections between AD and amyloid protein plaques in the brain. AD is a chronic disease that usually starts slowly and gets worse over time. The typical symptoms are memory loss, language disorders, mood swings and behavioral issues. Gradual losses of somatic functions eventually lead patients to death. Currently, the main therapeutic method is pharmacotherapy, which may temporarily reduce symptoms, but has many side effects. No current treatment can reverse AD's deterioration.
Infrared (IR) light therapy has been studied in a range of single and multiple irradiation protocols in previous studies and was found beneficial for neuropathology. In our research, we have verified the effect of infrared light on AD through Alzheimer's disease mouse model. This transgenic mouse model is made by co-injecting two vectors encoding mutant amyloid precursor protein (APP) and mutant presenilin-1 (PSEN1). We designed an experimental apparatus for treating mice, which primarily includes a therapeutic box and a LED array, which emits infrared light. After the treatment, we assessed the effects of infrared light by testing cognitive performance of the mice in Morris water maze.
Our results show that infra-red therapy is able to improve cognitive performance in the mouse model. It might provide a novel and safe way to treat Alzheimer's disease.
We have experimentally investigated supercontinuum generated by using different pulse dynamics patterns as the
pump pulses. These patterns, which include conventional mode-locked single pulse, condensed phase pulses and
pulsed bunches, were all directly produced from a mode-locked erbium-doped fiber laser based on a multi-layer
graphene saturable absorber. The strong third-order optical nonlinearity of graphene and all fiber cavity
configuration led to the multi-pulses operation states at a low pump power. A flat supercontinuum with 20-dB width
of 550 nm from 1200 nm to 1750 nm have all been obtained by seeding the amplified conventional mode-locked
single pulse and condensed phase pulses into a segment of photonic crystal fiber. On the other hand, experimental
results also show that the pulsed bunches was not conducive to form a flat supercontinuum.