Prof. Michael P. Andre Profile

Prof. Michael P. Andre

Professor of Radiology

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Publications (7)

Proceedings Article | 22 May 2003 Paper

ROC analysis of lesion descriptors in breast ultrasound images

Michael Andre, Michael Galperin, Peter Phan, Peter Chiu

Proceedings Volume 5034, (2003) https://doi.org/10.1117/12.480333

KEYWORDS: Breast, Ultrasonography, Databases, Biopsy, Image segmentation, Mammography, Solids, Statistical analysis, Imaging systems, Image processing

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Proceedings Article | 3 July 2001 Paper

Investigation of a method to assess breast ultrasound level of suspicion

Michael Andre, Michael Galperin, Linda Olson, Susan Payrovi, Katherine Richman, D. Blickenstaff

Proceedings Volume 4322, (2001) https://doi.org/10.1117/12.431034

KEYWORDS: Breast, Ultrasonography, Image segmentation, Biopsy, Solids, Databases, Image processing, Medical imaging, Software development, Cancer

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Proceedings Article | 28 May 1999 Paper

Evaluation of real-time acoustical holography for breast imaging and biopsy guidance

Constance Lehman, Michael Andre, Barbara Fecht, Jennifer Johansen, Ronald Shelby, Jerod Shelby

Proceedings Volume 3659, (1999) https://doi.org/10.1117/12.349498

KEYWORDS: Breast, Mammography, Tissue optics, Tissues, Ultrasonography, Biopsy, Tumors, Breast imaging, Diagnostics, Holography

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Ultrasound is an attractive modality for adjunctive characterization of certain breast lesions, but it is not considered specific for cancer and it is not recommended for screening. An imaging technique remarkably different from pulse-echo ultrasound, termed Optical Sonography^TM (Advanced Diagnostics, Inc.), uses the through-transmission signal. The method was applied to breast examinations in 41 asymptomatic and symptomatic women ranging in age from 18 to 83 years to evaluate this imaging modality for detection and characterization of breast disease and normal tissue. This approach uses coherent sound and coherent light to produce real-time, large field-of-view images with pronounced edge definition in soft tissues of the body. The system patient interface was modified to improve coupling to the breast and bring the chest wall to within 3 cm of the sound beam. System resolution (full width half maximum of the line-spread function) was 0.5 mm for a swept-frequency beam centered at 2.7 MHz. Resolution degrades slightly in the periphery of the very large 15.2-cm field of view. Dynamic range of the reconstructed 'raw' images (no post processing) was 3000:1. Included in the study population were women with dense parenchyma, palpable ductal carcinoma in situ with negative mammography, superficial and deep fibroadenomas, and calcifications. Successful breast imaging was performed in 40 of 41 women. These images were then compared with images generated using conventional X-ray mammography and pulse-echo ultrasound. Margins of lesions and internal textures were particularly well defined and provided substantial contrast to fatty and dense parenchyma. In two malignant lesions, Optical Sonography^TM appeared to approximate more closely tumor extent compared to mammography than pulse-echo sonography. These preliminary studies indicate the method has unique potential for detecting, differentiating, and guiding the biopsy of breast lesions using real-time acoustical holography.

Proceedings Article | 24 July 1998 Paper

Investigation of an acoustical holography system for real-time imaging

Barbara Fecht, Michael Andre, George Garlick, Ronald Shelby, Jerod Shelby, Constance Lehman

Proceedings Volume 3336, (1998) https://doi.org/10.1117/12.317008

KEYWORDS: Ultrasonography, Imaging systems, Acoustics, Biopsy, Holography, Tissues, Transducers, Breast, Tissue optics, Reflectivity

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Proceedings Article | 24 July 1998 Paper

Integrated CMOS-selenium x-ray detector for digital mammography

Michael Andre, Brett Spivey, Peter Martin, Arthur Morsell, Eugene Atlas, Tony Pellegrino

Proceedings Volume 3336, (1998) https://doi.org/10.1117/12.317019

KEYWORDS: Sensors, Selenium, X-rays, Mammography, Image sensors, Breast, X-ray detectors, Digital mammography, CMOS sensors, Transistors

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This paper describes a novel area detector for direct conversion and readout of the x-ray energy that eliminates multiple conversions and coupling stages which degrade performance. The pixel array and readout electronics are fabricated on the same piece of silicon. The detector consists of a uniform layer (approximately 300 micrometers) of amorphous selenium alloy vapor-deposited on an electronic readout array fabricated using conventional complementary metal oxide semiconductor (CMOS). The CMOS array features 66 micrometer pixels in a 1024 X 832 array providing a 5.5 X 6.75 cm image area. Each pixel has active circuitry including signal amplification, pixel selection and reset, while peripheral circuitry on one end of the array provides shift registers, sample and hold and multiplexing. The CMOS readout array was fabricated at a standard facility on a 10-cm diameter silicon wafer using 2 micrometer CMOS process. Fifteen separate image sensors were assembled for evaluation in a 3 X 5 format to provide a 20 X 27 cm composite field of view. Missing data between sensors is recovered by acquiring three sub-exposures, between which the array is translated diagonally approximately 2 mm. Total exposure time for an average breast is less than one second. Conversion efficiency was found to be approximately 120 electrons per absorbed x-ray (19 keV average). Electronic readout noise was measured to be 2.4 ADU corresponding to approximately 500 electrons. Detective quantum efficiency was found to be 0.65 at low spatial frequency (0.25 lp/mm) and at 0.2 at high spatial frequency (8 lp/mm) for x-ray fluence ranging from 5 - 35 mR. Images of an ACR phantom show visualization of all of the fibers, specks and masses when displayed with a linear lookup table on a high-resolution monitor. These studies demonstrated that there is a slight but measurable image retention evident as 'ghost' images. The two most effective means to reduce this effect are flushing the sensors with infrared light or x-rays between exposures and reversing the applied voltage on the selenium layer. A number of improvements designed to increase sensitivity and reduce noise also have been identified and are being implemented. Sample images were acquired from four volunteer human subjects at exposure factors identical to their film-screen mammograms. The results suggest that the detector performance is suitable for further clinical investigation.

Proceedings Article | 7 May 1997 Paper

Three-dimensional holographic display of ultrasound computed tomograms

Michael Andre, Helmar Janee, Mariana Ysrael, Jeurg Hodler, Linda Olson, George Leopold, Raymond Schulz

Proceedings Volume 3031, (1997) https://doi.org/10.1117/12.273944

KEYWORDS: Holography, Holograms, Breast, Digital holography, Ultrasonography, 3D displays, Transducers, Computed tomography, 3D image processing, Computing systems

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Proceedings Article | 2 May 1997 Paper

Optimization of tungsten x-ray spectra for digital mammography: a comparison of model to experiment

Michael Andre, Brett Spivey

Proceedings Volume 3032, (1997) https://doi.org/10.1117/12.274009

KEYWORDS: Breast, Signal to noise ratio, Optical filters, X-rays, Tin, Molybdenum, Silver, Tungsten, Digital mammography, Quantum efficiency

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Showing 5 of 7 publications

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