Dr. Michael R. Hamblin Profile

Dr. Michael R. Hamblin

Research Associate/Professor at Wellman Ctr for Photomedicine

SPIE Involvement:

Publications (88)

SPIE Conference Volume | May 2, 2018

Mechanisms of Photobiomodulation Therapy XIII

PROCEEDINGS ARTICLE | March 14, 2018

Decacationic [70]fullerenyl-light harvesting chromophore conjugates for efficient photokilling of infectious bacteria (Conference Presentation)

Proc. SPIE. 10479, Light-Based Diagnosis and Treatment of Infectious Diseases

KEYWORDS: Oxygen, Chromophores, Pathogens, Photochemistry, Fullerenes, Bacteria

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PROCEEDINGS ARTICLE | March 14, 2018

Photobiomodulation for the brain: has the light dawned? (Conference Presentation)

Proc. SPIE. 10477, Mechanisms of Photobiomodulation Therapy XIII

KEYWORDS: Light emitting diodes, Laser therapeutics, Ischemia, Head, Traumatic brain injury, Tissue optics, Alzheimer's disease, Dementia, Synaptogenesis, Brain

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PROCEEDINGS ARTICLE | March 14, 2018

Effects of low level light therapy and NO on light irradiation efficacy of ruthenium-phthalocyanine complexes as a function of radical species formation. (Conference Presentation)

Proc. SPIE. 10477, Mechanisms of Photobiomodulation Therapy XIII

KEYWORDS: Photodynamic therapy, Modulation, Nitrogen, Oxygen, Melanoma, NOx, Acquisition tracking and pointing, Ruthenium, Low level phototherapy, Mode conditioning cables

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PROCEEDINGS ARTICLE | March 14, 2018

Potentiation of antimicrobial photodynamic inactivation by potassium iodide and other inorganic salts (Conference Presentation)

Proc. SPIE. 10479, Light-Based Diagnosis and Treatment of Infectious Diseases

KEYWORDS: Potassium, Skin, Hydrogen, Oxygen, Iodine, Picosecond phenomena, In vivo imaging, Sodium, Mouse models, Bacteria

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PROCEEDINGS ARTICLE | March 14, 2018

Antimicrobial photodynamic inactivation mediated by a class of dual-action light-activated antibiotics: tetracyclines is potentiated by potassium iodide (Conference Presentation)

Proc. SPIE. 10479, Light-Based Diagnosis and Treatment of Infectious Diseases

KEYWORDS: Potassium, Photodynamic therapy, Hydrogen, Resistance, Oxygen, Iodine, Picosecond phenomena, Photosensitizer targeting, Bacteria

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PROCEEDINGS ARTICLE | March 8, 2018

Potentiation by potassium iodide using TPPS4 for antimicrobial photodynamic inactivation

Proc. SPIE. 10479, Light-Based Diagnosis and Treatment of Infectious Diseases

KEYWORDS: Confocal microscopy, Potassium, Titanium dioxide, Oxygen, Microorganisms, Iodine, Yeast, Picosecond phenomena, Sodium, Bacteria

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PROCEEDINGS ARTICLE | February 8, 2018

Potassium iodide potentiates antimicrobial photodynamic inactivation mediated by Rose Bengal: in vitro and in vivo studies

Proc. SPIE. 10479, Light-Based Diagnosis and Treatment of Infectious Diseases

KEYWORDS: Potassium, Photodynamic therapy, Luminescence, Hydrogen, Oxygen, Iodine, Picosecond phenomena, Bioluminescence, In vivo imaging, Bacteria

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SPIE Press Book | January 20, 2018

Low-Level Light Therapy: Photobiomodulation

Hamblin, Michael , Carroll, James , de Freitas, Lucas Freitas , Huang, Ying-Ying , Ferraresi, Cleber

PROCEEDINGS ARTICLE | April 19, 2017

Strategies to potentiate immune response after photodynamic therapy (Conference Presentation)

Proc. SPIE. 10065, Biophotonics and Immune Responses XII

KEYWORDS: Visible radiation, Oncology, Photodynamic therapy, Biomedical optics, Cancer, Tumors, Pathogens, Receptors, Photomedicine, Animal model studies

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PROCEEDINGS ARTICLE | April 19, 2017

Photobiomodulation of the brain: a new paradigm (Conference Presentation)

Proc. SPIE. 10048, Mechanisms of Photobiomodulation Therapy XII

KEYWORDS: Near infrared, Light emitting diodes, Ischemia, Semiconductor lasers, Head, Traumatic brain injury, Tissue optics, Alzheimer's disease, Dementia, Brain

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SPIE Conference Volume | March 30, 2017

Mechanisms of Photobiomodulation Therapy XII

SPIE Conference Volume | June 28, 2016

Mechanisms of Photobiomodulation Therapy XI

PROCEEDINGS ARTICLE | April 27, 2016

Renaissance in tumor immunotherapy: possible combination with phototherapy (Conference Presentation)

Proc. SPIE. 9709, Biophotonics and Immune Responses XI

KEYWORDS: Visible radiation, Proteins, Phototherapy, Oncology, Photodynamic therapy, Tumor growth modeling, Cancer, Tumors, Oxygen, Toxicity

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PROCEEDINGS ARTICLE | April 27, 2016

The effect of low level laser therapy on ventilator-induced lung injury in mice (Conference Presentation)

Proc. SPIE. 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III

KEYWORDS: Endoscopy, Light emitting diodes, Injuries, Laser therapeutics, Chest, Mechanics, Optical microscopy, Lung, Inflammation, In vivo imaging

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PROCEEDINGS ARTICLE | April 26, 2016

Nitromedicine: translating alternative medicine to evidence based medicine and redefining disease (Conference Presentation)

Proc. SPIE. 9695, Mechanisms of Photobiomodulation Therapy XI

KEYWORDS: Medicine, Phototherapy, Modulation, Electrons, Nitrogen, Oxygen, NOx, Therapeutics, Stem cells, Mode conditioning cables

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PROCEEDINGS ARTICLE | April 26, 2016

Photobiomodulation and the brain: a new paradigm (Conference Presentation)

Proc. SPIE. 9695, Mechanisms of Photobiomodulation Therapy XI

KEYWORDS: Photomedicine, Current controlled current source, Brain

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SPIE Journal Paper | March 23, 2016

Errata: Transcranial low-level laser therapy (810 nm) temporarily inhibits peripheral nociception: photoneuromodulation of glutamate receptors, prostatic acid phophatase, and adenosine triphosphate

Pires de Sousa, Marcelo Victor , Ferraresi, Cleber , Kawakubo, Masayoshi , Kaippert, Beatriz , Yoshimura, Elisabeth , Hamblin, Michael

NPh Vol. 3 Issue 01

KEYWORDS: Laser therapeutics, Receptors, Photomedicine, Physics, Nervous system, Radiation dosimetry, Medical physics, Biotechnology, Biomedical optics, Dermatology

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SPIE Journal Paper | March 4, 2016

Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis

Cassano, Paolo , Petrie, Samuel , Hamblin, Michael , Henderson, Theodore , Iosifescu, Dan

NPh Vol. 3 Issue 03

KEYWORDS: Near infrared, Traumatic brain injury, Brain, Skin, Neurogenesis, Light emitting diodes, Mode conditioning cables, Inflammation, Light, Neurophotonics

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SPIE Journal Paper | January 25, 2016

Transcranial low-level laser therapy (810 nm) temporarily inhibits peripheral nociception: photoneuromodulation of glutamate receptors, prostatic acid phophatase, and adenosine triphosphate

Kawakubo, Masayoshi , Pires de Sousa, Marcelo Victor , Ferraresi, Cleber , Kaippert, Beatriz , Yoshimura, Elisabeth , Hamblin, Michael

NPh Vol. 3 Issue 01

KEYWORDS: Laser therapeutics, Tissues, Brain, Receptors, Acquisition tracking and pointing, Neurons, Laser irradiation, Laser damage threshold, Luminescence, Inflammation

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PROCEEDINGS ARTICLE | May 22, 2015

Antimicrobial blue light therapy for Candida albicans burn infection in mice

Proc. SPIE. 9467, Micro- and Nanotechnology Sensors, Systems, and Applications VII

KEYWORDS: Light emitting diodes, Real time imaging, Phototherapy, Statistical analysis, Luminescence, Resistance, Pathogens, Bioluminescence, In vivo imaging, In vitro testing

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PROCEEDINGS ARTICLE | May 22, 2015

Red/near-infrared light-emitting diode therapy for traumatic brain injury

Proc. SPIE. 9467, Micro- and Nanotechnology Sensors, Systems, and Applications VII

KEYWORDS: Near infrared, Light emitting diodes, Medicine, Injuries, Head, Holmium, Traumatic brain injury, Cognition, Molybdenum, Brain

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SPIE Conference Volume | March 25, 2015

Mechanisms for Low-Light Therapy X

PROCEEDINGS ARTICLE | March 9, 2015

Strategies to potentiate immune response after photodynamic therapy

Proc. SPIE. 9324, Biophotonics and Immune Responses X

KEYWORDS: Oncology, Photodynamic therapy, Cancer, Tumors, Lung, Oxygen, Pathogens, Receptors, Picosecond phenomena, Lymphatic system

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PROCEEDINGS ARTICLE | March 5, 2015

Transcranial low-level laser therapy increases memory, learning, neuroprogenitor cells, BDNF and synaptogenesis in mice with traumatic brain injury

Proc. SPIE. 9309, Mechanisms for Low-Light Therapy X

KEYWORDS: Near infrared, Injuries, Laser therapeutics, Image analysis, Head, Traumatic brain injury, Neurons, Neurogenesis, Synaptogenesis, Brain

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PROCEEDINGS ARTICLE | March 5, 2015

Low level light in combination with metabolic modulators for effective therapy

Proc. SPIE. 9309, Mechanisms for Low-Light Therapy X

KEYWORDS: Glucose, Injuries, Tissues, Oxygen, Hypoxia, Cell death, Acquisition tracking and pointing, Traumatic brain injury, Neurons, Brain

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PROCEEDINGS ARTICLE | March 5, 2015

Low level laser (light) therapy and photobiomodulation: the path forward

Proc. SPIE. 9309, Mechanisms for Low-Light Therapy X

KEYWORDS: Target detection, Phototherapy, Laser therapeutics, Detection and tracking algorithms, Imaging systems, Sensors, Linear filtering, Digital imaging, Low level phototherapy, Channel projecting optics

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SPIE Journal Paper | October 7, 2014

Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice

Xuan, Weijun , Vatansever, Fatma , Huang, Liyi , Hamblin, Michael

JBO Vol. 19 Issue 10

KEYWORDS: Traumatic brain injury, Laser therapeutics, Brain, Neurogenesis, Phototherapy, Neurons, Proteins, Injuries, Image analysis, Low level phototherapy

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PROCEEDINGS ARTICLE | March 4, 2014

Photodynamic therapy improves the ultraviolet-irradiated hairless mice skin

Proc. SPIE. 8926, Photonic Therapeutics and Diagnostics X

KEYWORDS: Light sources, Photodynamic therapy, Skin, Ultraviolet radiation, Lamps, Collagen, Skin cancer, Picosecond phenomena, Tissue optics, Mouse models

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SPIE Conference Volume | March 3, 2014

Mechanisms for Low-Light Therapy IX

PROCEEDINGS ARTICLE | February 28, 2014

Photodynamic therapy for melanoma: efficacy and immunologic effects

Proc. SPIE. 8944, Biophotonics and Immune Responses IX

KEYWORDS: Photodynamic therapy, Cancer, Tumors, Molecules, Control systems, Oxygen, Melanoma, Information technology, Picosecond phenomena, Mouse models

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PROCEEDINGS ARTICLE | February 18, 2014

Low-level light therapy (LLLT) for cosmetics and dermatology

Proc. SPIE. 8932, Mechanisms for Low-Light Therapy IX

KEYWORDS: Phototherapy, Wound healing, Laser therapeutics, Tissues, Dermatology, Skin, Collagen, Scanning electron microscopy, Inflammation, Low level phototherapy

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SPIE Journal Paper | September 12, 2013

Low-level laser therapy for spinal cord injury in rats: effects of polarization

Ando, Takahiro , Sato, Shunichi , Kobayashi, Hiroaki , Nawashiro, Hiroshi , Ashida, Hiroshi , Hamblin, Michael

JBO Vol. 18 Issue 09

KEYWORDS: Polarization, Spinal cord, Injuries, Laser therapeutics, Tissue optics, Acquisition tracking and pointing, Laser irradiation, Tissues, Photons, Optical fibers

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SPIE Conference Volume | March 15, 2013

Mechanisms for Low-Light Therapy VIII

PROCEEDINGS ARTICLE | March 5, 2013

Transcranial low-level light therapy produces neuroprotection, neurogenesis and BDNF after TBI in mice

Proc. SPIE. 8569, Mechanisms for Low-Light Therapy VIII

KEYWORDS: Injuries, Laser therapeutics, Tissues, Cell death, Traumatic brain injury, Low level phototherapy, Mouse models, Neurons, Neurogenesis, Brain

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We have previously shown that transcranial low level light therapy (LLLT) can ameliorate brain damage in mice subjected to traumatic brain injury and improve neurological function. We used a 810-nm laser and delivered 18 J/cm2 at an irradiance 25 mW/cm2. LLLT was either delivered once at 4 hours after controlled cortical impact TBI, once a day for 3 days, or once a day for 14 days. One and 3 applications of LLLT had beneficial effects on the mice, with 3 being better than 1, but 14 applications had no beneficial effect. We now report immunofluorescence studies in mouse brain sections that offer some explanation for this intriguing finding. Mice were injected with BrdU for 1 week before sacrifice (a marker for proliferating cells) and antibodies to double cortin (DCX-1,a marker of migrating neurons), Tuj-1 ( a marker of neuroprogenitor cells), BDNF (brain derived neurotrophic factor) and synapsin-1 ( a marker for newly formed synaptic connections between existing neurons). We found increased BrdU incorporation indicating proliferating cells in the dentate gyrus of the hippocampus, the subventricular layer of the lateral ventricle, as well as the brain tissue surrounding the cortical lesion. Interestingly these cells were more abundant at 7 days than at 28 days post TBI. Co-labeling of BrdU with Neu-N was performed indicating that the proliferating cells were in fact neuronal in nature. Mice with 3 laser treatments had much more BrdU incorporation than mice with 14. Upregulation of BDNF was seen at 7 days, and increased expression of DCX-1 and Tuj-1 was seen at 28 days in the lesion region, indication that neuroprogenitor cells may have migrated there from sites of neurogenesis. Increased syapsin-1 was seen in the cortex at 28 days indicating that neural plasticity may be stimulated by LLLT. Taken together these data suggest that transcranial LLLT may have applications beyond TBI in areas such as neurodegenerative disease and psychiatric disorders.

PROCEEDINGS ARTICLE | February 22, 2013

Photodynamic therapy stimulates anti-tumor immune response in mouse models: the role of regulatory Tcells, anti-tumor antibodies, and immune attacks on brain metastases

Proc. SPIE. 8582, Biophotonics and Immune Responses VIII

KEYWORDS: Oncology, Photodynamic therapy, Cancer, Tumors, Colon, Picosecond phenomena, Therapeutics, Lung cancer, Mouse models, Brain

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SPIE Conference Volume | March 20, 2012

Mechanisms for Low-Light Therapy VII

PROCEEDINGS ARTICLE | March 10, 2012

In vivo studies of low level laser (light) therapy for traumatic brain injury

Proc. SPIE. 8211, Mechanisms for Low-Light Therapy VII

KEYWORDS: Phototherapy, Injuries, Laser therapeutics, Traumatic brain injury, Low level phototherapy, Mouse models, Neurons, Neurogenesis, Brain, Clinical trials

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PROCEEDINGS ARTICLE | March 10, 2012

Effects of polarization in low-level laser therapy of spinal cord injury in rats

Proc. SPIE. 8211, Mechanisms for Low-Light Therapy VII

KEYWORDS: Injuries, Laser therapeutics, Polarization, Tissues, Photons, Laser irradiation, Acquisition tracking and pointing, Spinal cord, Tissue optics, Laser tissue interaction

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PROCEEDINGS ARTICLE | March 10, 2012

Low level laser therapy reduces oxidative stress in cortical neurons in vitro

Proc. SPIE. 8211, Mechanisms for Low-Light Therapy VII

KEYWORDS: Injuries, Laser therapeutics, Photons, Hydrogen, Calcium, Oxygen, Acquisition tracking and pointing, Traumatic brain injury, In vitro testing, Neurons

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PROCEEDINGS ARTICLE | February 9, 2012

Photodynamic therapy can induce non-specific protective immunity against a bacterial infection

Proc. SPIE. 8224, Biophotonics and Immune Responses VII

KEYWORDS: Defense and security, Light emitting diodes, Photodynamic therapy, Statistical analysis, Tissues, Surgery, Image processing, In vivo imaging, Bacteria, Data analysis

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PROCEEDINGS ARTICLE | February 18, 2011

Cryptococcus neoformans capsule protects cell from oxygen reactive species generated by antimicrobial photodynamic inactivation

Proc. SPIE. 7887, Mechanisms for Low-Light Therapy VI

KEYWORDS: Photodynamic therapy, Luminescence, Ions, Oxygen, Microorganisms, Yeast, Picosecond phenomena, Confocal laser scanning microscopy, Fungi, Brain

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PROCEEDINGS ARTICLE | February 18, 2011

Oxidative stress of photodynamic antimicrobial chemotherapy inhibits Candida albicans virulence

Proc. SPIE. 7887, Mechanisms for Low-Light Therapy VI

KEYWORDS: Photodynamic therapy, Tissues, Oxygen, Microorganisms, Pathogens, Cell death, Photoacoustic tomography, Yeast, Picosecond phenomena, In vivo imaging

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PROCEEDINGS ARTICLE | February 18, 2011

Effects of 810 nm laser on mouse primary cortical neurons

Proc. SPIE. 7887, Mechanisms for Low-Light Therapy VI

KEYWORDS: Injuries, Laser therapeutics, Luminescence, Calcium, Signal processing, NOx, Acquisition tracking and pointing, Low level phototherapy, Neurons, Brain

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SPIE Conference Volume | February 10, 2011

Mechanisms for Low-Light Therapy VI

PROCEEDINGS ARTICLE | February 9, 2011

The potential role of functional inhibition of T regulatory cells by anti-TGF-beta antibody in photodynamic therapy of renal cancer

Proc. SPIE. 7900, Biophotonics and Immune Responses VI

KEYWORDS: Photodynamic therapy, Tumor growth modeling, Cancer, Tumors, Tissues, Molecules, Oxygen, Picosecond phenomena, In vitro testing, Animal model studies

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SPIE Journal Paper | March 1, 2010

Dye-enhanced multimodal confocal microscopy for noninvasive detection of skin cancers in mouse models

Park, Jesung , Mroz, Pawel , Hamblin, Michael , Yaroslavsky, Anna

JBO Vol. 15 Issue 02

KEYWORDS: Luminescence, Reflectivity, Confocal microscopy, Melanoma, In vivo imaging, Skin cancer, Tumors, Cancer, Tissues, Confocal fluorescent microscopy

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PROCEEDINGS ARTICLE | February 26, 2010

Transcranial LED therapy for cognitive dysfunction in chronic, mild traumatic brain injury: two case reports

Proc. SPIE. 7552, Mechanisms for Low-Light Therapy V

KEYWORDS: Near infrared, Light emitting diodes, Injuries, Magnetic resonance imaging, Photons, Light-emitting diode therapy, Head, Diodes, Traumatic brain injury, Brain

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PROCEEDINGS ARTICLE | February 26, 2010

Can dendritic cells see light?

Proc. SPIE. 7565, Biophotonics and Immune Responses V

KEYWORDS: Confocal microscopy, Near infrared, Proteins, Light emitting diodes, Wound healing, Laser therapeutics, Laser marking, Bone, Inflammation, Flow cytometry

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PROCEEDINGS ARTICLE | February 26, 2010

Comparison of cellular responses induced by low level light in different cell types

Proc. SPIE. 7552, Mechanisms for Low-Light Therapy V

KEYWORDS: Proteins, Medicine, Cancer, Luminescence, Oxygen, Bone, NOx, Acquisition tracking and pointing, In vitro testing, Neurons

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PROCEEDINGS ARTICLE | February 26, 2010

Low level laser therapy for traumatic brain injury

Proc. SPIE. 7552, Mechanisms for Low-Light Therapy V

KEYWORDS: Injuries, Laser therapeutics, Tissues, Control systems, Inflammation, Head, Cell death, Traumatic brain injury, Low level phototherapy, Brain

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SPIE Conference Volume | February 17, 2010

Mechanisms for Low-Light Therapy V

PROCEEDINGS ARTICLE | February 11, 2010

Photodynamic therapy for cancer and activation of immune response

Proc. SPIE. 7565, Biophotonics and Immune Responses V

KEYWORDS: Proteins, Photodynamic therapy, Cancer, Tumors, Molecules, Oxygen, Signal processing, Receptors, Picosecond phenomena, Animal model studies

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