Mr. Michael Tillge Lund Profile

Michael Tillge Lund

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Proceedings Article | 29 April 2005 Paper

Shape regression for vertebra fracture quantification

Michael Tillge Lund, Marleen de Bruijne, Laszlo Tanko, Mads Nielsen

Proceedings Volume 5747, (2005) https://doi.org/10.1117/12.595729

KEYWORDS: Bone, Data modeling, Diagnostics, Received signal strength, Error analysis, Reconstruction algorithms, Statistical analysis, Radiography, Shape analysis, Basic research

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Accurate and reliable identification and quantification of vertebral fractures constitute a challenge both in clinical trials and in diagnosis of osteoporosis. Various efforts have been made to develop reliable, objective, and reproducible methods for assessing vertebral fractures, but at present there is no consensus concerning a universally accepted diagnostic definition of vertebral fractures. In this project we want to investigate whether or not it is possible to accurately reconstruct the shape of a normal vertebra, using a neighbouring vertebra as prior information. The reconstructed shape can then be used to develop a novel vertebra fracture measure, by comparing the segmented vertebra shape with its reconstructed normal shape. The vertebrae in lateral x-rays of the lumbar spine were manually annotated by a medical expert. With this dataset we built a shape model, with equidistant point distribution between the four corner points. Based on the shape model, a multiple linear regression model of a normal vertebra shape was developed for each dataset using leave-one-out cross-validation. The reconstructed shape was calculated for each dataset using these regression models. The average prediction error for the annotated shape was on average 3%.

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