Ms. Michaela Taylor-Williams Profile

Michaela Taylor-Williams

Student at Univ of Cambridge

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Publications (9)

SPIE Journal Paper | 29 March 2024 Open Access

Targeted multispectral filter array design for the optimization of endoscopic cancer detection in the gastrointestinal tract

Michaela Taylor-Williams, Ran Tao, Travis Sawyer, Dale Waterhouse, Jonghee Yoon, Sarah E. Bohndiek

JBO, Vol. 29, Issue 03, 036005, (March 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.3.036005

KEYWORDS: Tunable filters, Tissues, Colon, Optical filters, Design, Endoscopy, Cancer detection, Image classification, Scattering, Image filtering

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Proceedings Article | 13 March 2024 Presentation

Multispectral imaging in nailfold capillaroscopy for the detection of systemic sclerosis

Michaela Taylor-Williams, Irsa Khalil, Graham Dinsdale, Joanne Manning, Michael Berks, Andrea Murray, Sarah Bohndiek

Proceedings Volume PC12827, PC128270M (2024) https://doi.org/10.1117/12.3002477

KEYWORDS: Multispectral imaging, Capillaries, Cameras, Vascular diseases, Oxygenation, Light sources, Imaging systems, Image segmentation, Control systems, Visualization

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Proceedings Article | 17 March 2023 Presentation

Variable oxygenation blood flow phantoms for calibration of spectral imaging techniques

Michaela Taylor-Williams, Graham Spicer, Sarah Bohndiek

Proceedings Volume PC12363, PC123630N (2023) https://doi.org/10.1117/12.2649809

KEYWORDS: Imaging spectroscopy, Spectral calibration, Calibration, Blood circulation, Blood, Oxygen, Lithography, Tissues, Microfluidics, Light sources

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Proceedings Article | 16 March 2023 Presentation

Optimization of multispectral filter arrays for detection of cancers in the gastrointestinal tract (Conference Presentation)

Michaela Taylor-Williams, Ran Tao, Travis Sawyer, Dale Waterhouse, Jonghee Yoon, Sarah Bohndiek

Proceedings Volume PC12387, PC1238707 (2023) https://doi.org/10.1117/12.2649817

KEYWORDS: Cancer, Detector arrays, Multispectral imaging, Colon, Tissues, Reflectivity, Esophagus, Endoscopy, Cameras, Surveillance

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SPIE Journal Paper | 12 December 2022 Open Access

Multispectral imaging of nailfold capillaries using light-emitting diode illumination

Michaela Taylor-Williams, Stephen Mead, Travis Sawyer, Lina Hacker, Calum Williams, Michael Berks, Andrea Murray, Sarah Bohndiek

JBO, Vol. 27, Issue 12, 126002, (December 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.12.126002

KEYWORDS: Light emitting diodes, Capillaries, LED lighting, Oxygenation, Blood, Reflectivity, Multispectral imaging, Modeling, Imaging systems, Systems modeling

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SPIE Journal Paper | 3 August 2022 Open Access

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

Michaela Taylor-Williams, Graham Spicer, Gemma Bale, Sarah E. Bohndiek

JBO, Vol. 27, Issue 08, 080901, (August 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.8.080901

KEYWORDS: Tissue optics, Oximetry, Optical coherence tomography, Absorption, Imaging systems, Optical imaging, Blood, Tissues, Optical sensing, Spatial resolution

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Proceedings Article | 2 March 2022 Presentation + Paper

Spectrally tailored hyperpixel filter arrays for efficient imaging of chemical compositions

Michaela Taylor-Williams, Richard Cousins, Calum Williams, Sarah Bohndiek, Christopher Mellor, George S. Gordon

Proceedings Volume 11954, 1195406 (2022) https://doi.org/10.1117/12.2606917

KEYWORDS: Multispectral imaging, Signal to noise ratio, Optical filters, Image filtering, Imaging arrays, Fabry–Perot interferometers, Sensors, Imaging spectroscopy, Bandpass filters, Silver, Indocyanine green

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We present a method for designing and fabricating 'HyperPixels': pixel filter arrays with custom spectral transmission properties that enable efficient imaging of specific chromophores or fluorophores. Multispectral imaging typically targets particular spectral bands to uncover the spectral properties of tissue in combination with spatial resolution. Unmixing spectral properties can uncover the type and quantity of chromophores or fluorophores due to their unique spectral absorption or emission. Pixelated filter arrays atop imaging sensors are low-cost techniques used to achieve multispectral imaging. Typically, the filter pixels exhibit bandpass spectral behaviour, allowing only a fraction of the incident light to reach the sensor. As a result, narrowband filter pixels trade off high spectral resolution with optical power loss. A way to avoid this issue and improve the signal to noise ratio (SNR) for individual targets is to use a filter array where individual pixels are matched to a target chemical compound's reflectance or emission spectrum. Simulations show a >5-fold improvement in SNR under realistic noise conditions. These matched optical filters can also reduce the complexity of software or hardware spectral unmixing algorithms, offering the potential for real-time imaging of target compounds. We present a method for tailoring spectral transmission of individual pixels by building HyperPixels comprising multiple Fabry-Perot resonator subpixels with varying bandpass properties (FWHM = approximately 50-60 nm, thicknesses 75-150 nm) that collectively have the desired transmission spectrum. We used a numerical optimization process to design filter arrays for simultaneous detection of methylene blue and indocyanine green, commonly used in cancer diagnostics by clinicians. We then fabricated filters for indocyanine green detection using grayscale lithography with pixel sizes down to 5 μm and individual subpixels down to 0.5 μm and characterized them for their spectral properties.

Proceedings Article | 5 March 2021 Presentation

A low-cost LED-based multispectral capillaroscopy system for oximetry of the nailfold

Michaela Taylor-Williams, Steven Mead, Travis Sawyer, Lina Hacker, Calum Williams, Michael Berks, Andrea Murray, Sarah Bohndiek

Proceedings Volume 11651, 116510J (2021) https://doi.org/10.1117/12.2575869

KEYWORDS: Light emitting diodes, Oximetry, Capillaries, Visualization, Reflectivity, RGB color model, Modeling, Imaging systems, Hypoxia, Control systems

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Proceedings Article | 5 March 2021 Presentation

Hyperspectral imaging and analysis of the nailfold capillaries

Michaela Taylor-Williams, Calum Williams, Michael Berks, Andrea Murray, Sarah Bohndiek

Proceedings Volume 11655, 116551H (2021) https://doi.org/10.1117/12.2575975

KEYWORDS: Capillaries, Hyperspectral imaging, Signal to noise ratio, Tissues, Signal processing, Absorbance, Tunable lasers, Oximetry, Optical filters, Denoising

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Showing 5 of 9 publications

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